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学科主题临床医学
Recurrent ovarian clear cell carcinoma: a retrospective evaluation of the efficacy and prognostic factors
Song, Nan; Yan, Xin; Gao, Yunong
通讯作者Gao, Yunong(1)
关键词Clear cell carcinoma Recurrence Second-line chemotherapy Irinotecan
刊名EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
2018
DOI10.12892/ejgo4027.2018
39期:4页:569-574
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]1ST-LINE CHEMOTHERAPY ; 2ND-LINE CHEMOTHERAPY ; CANCER STATISTICS ; POOR-PROGNOSIS ; ADENOCARCINOMA ; PACLITAXEL ; WOMEN ; TRIAL
英文摘要

Purpose: The aim of this study was to investigate the effectiveness of treatment and prognostic factors in patients with recurrent ovarian clear cell carcinoma. Materials and Methods: The 78 patients with ovarian clear cell carcinoma (CCC) in Peking University Cancer Hospital from 1996 to 2015 received laparotomy and initial chemotherapy. The efficacy of surgery, chemotherapy, and prognosis of patients with recurrent CCC were evaluated. Results: The overall response rate (RR) to platinum based chemotherapy of PTX + platinum regimen showed no significant correlation with PFI in this study (p = 0.683). According to non-platinum regimen, irinotecan + mitomycin C regimen had a higher activity (RR = 41.7%) compared with topotecan regimen (RR = 20%). The overall survival (OS) had a marked correlation with tumor staging (p = 0.027), residuals (p = 0.019), second-line chemotherapy response (p = 0.003), and progression free survival (PFS, p = 0.014). Conclusions: No residual tumor in initial surgery is critical for the prognosis of patients with CCC, even in optimal cytoreductive surgery. Irinotecan, as one kind of effective chemotherapy regimen, is preferred to be conducted in patients with recurrent CCC.

语种英语
WOS记录号WOS:000444419100010
通讯作者邮箱yunonggao1121@126.com
第一作者单位Peking Univ, Canc Hosp & Inst, Minist Educ, Dept Gynecol,Key Lab Carcinogenesis & Translat Re, 52 Fucheng Rd, Beijing 100142, Peoples R China
通讯作者单位Peking Univ, Canc Hosp & Inst, Minist Educ, Dept Gynecol,Key Lab Carcinogenesis & Translat Re, 52 Fucheng Rd, Beijing 100142, Peoples R China
ISSN0392-2936
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145565
专题北京大学临床肿瘤学院_妇科肿瘤科
作者单位Peking Univ, Canc Hosp & Inst, Minist Educ, Dept Gynecol,Key Lab Carcinogenesis & Translat Re, 52 Fucheng Rd, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Song, Nan,Yan, Xin,Gao, Yunong. Recurrent ovarian clear cell carcinoma: a retrospective evaluation of the efficacy and prognostic factors[J]. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,2018,39(4):569-574.
APA Song, Nan,Yan, Xin,&Gao, Yunong.(2018).Recurrent ovarian clear cell carcinoma: a retrospective evaluation of the efficacy and prognostic factors.EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,39(4),569-574.
MLA Song, Nan,et al."Recurrent ovarian clear cell carcinoma: a retrospective evaluation of the efficacy and prognostic factors".EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 39.4(2018):569-574.
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