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学科主题临床医学
Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing
Wang, Ping1,2; Chen, Yidong1,3,4; Yong, Jun1,4; Cui, Yueli1,2; Wang, Rui1,2; Wen, Lu1,2; Qiao, Jie1,3,4,5; Tang, Fuchou1,2,3
通讯作者Qiao, Jie(1,3,4,5) ; Tang, Fuchou(1,2,3)
刊名CELL REPORTS
2018-09-25
DOI10.1016/j.celrep.2018.08.056
24期:13页:3554-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]BRANCHING MORPHOGENESIS ; GENE-EXPRESSION ; SELF-RENEWAL ; NEPHRON ; MODEL ; MICE ; ORGANOIDS ; EPITHELIA ; DYSPLASIA ; PROTEIN
英文摘要

Healthy renal function depends on normal nephrogenesis during embryonic development. However, a comprehensive gene expression profile of human fetal kidney development remains largely unexplored. Here, using a single-cell RNA-sequencing technique, we analyzed > 3,000 human fetal renal cells spanning 4 months of development in utero. Unsupervised analysis identified two progenitor sub-types during cap mesenchyme development, suggesting a mechanism for sustaining their progenitor states. Furthermore, we identified critical transcriptional regulators and signaling pathways involved in the segmentation of nephron tubules. We explored the development of the highly heterogeneous collecting duct epithelia and dissected the metabolic gene repertoire and the extracellular matrix composition of the glomerular mesangium. The results provide insights on the molecular basis and regulatory events in human renal development. Moreover, the cell-type-specific expression features of causal genes in congenital renal diseases may be helpful in the treatment of these diseases.

语种英语
WOS记录号WOS:000445524700018
通讯作者邮箱jie.qiao@263.net ; tangfuchou@pku.edu.cn
第一作者单位Peking Univ, Coll Life Sci, Hosp 3, Beijing Adv Innovat Ctr Genom,Dept Obstet & Gynec, Beijing 100871, Peoples R China ; Minist Educ, Key Lab Cell Proliferat & Differentiat, Biomed Inst Pioneering Invest Via Convergence, Beijing 100871, Peoples R China
通讯作者单位Peking Univ, Coll Life Sci, Hosp 3, Beijing Adv Innovat Ctr Genom,Dept Obstet & Gynec, Beijing 100871, Peoples R China ; Minist Educ, Key Lab Cell Proliferat & Differentiat, Biomed Inst Pioneering Invest Via Convergence, Beijing 100871, Peoples R China ; Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China ; Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China ; Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
ISSN2211-1247
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145567
专题北京大学第三临床医学院_妇产科
北京大学第二临床医学院_重症医学科
北京大学临床肿瘤学院_病理科
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Coll Life Sci, Hosp 3, Beijing Adv Innovat Ctr Genom,Dept Obstet & Gynec, Beijing 100871, Peoples R China;
2.Minist Educ, Key Lab Cell Proliferat & Differentiat, Biomed Inst Pioneering Invest Via Convergence, Beijing 100871, Peoples R China;
3.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China;
4.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China;
5.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ping,Chen, Yidong,Yong, Jun,et al. Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing[J]. CELL REPORTS,2018,24(13):3554-+.
APA Wang, Ping.,Chen, Yidong.,Yong, Jun.,Cui, Yueli.,Wang, Rui.,...&Tang, Fuchou.(2018).Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing.CELL REPORTS,24(13),3554-+.
MLA Wang, Ping,et al."Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing".CELL REPORTS 24.13(2018):3554-+.
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