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学科主题临床医学
Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients
Ji, Dengbo1; Qiao, Meng1; Yao, Yunfeng1; Li, Ming1; Chen, Hailong2; Dong, Qi2; Jia, Jinying1; Cui, Xinxin1; Li, Zhaowei1; Xia, Jinhong1; Gu, Jin1,3,4
通讯作者Gu, Jin(1,3,4)
关键词Serum-based microRNA signature Colorectal cancer Adjuvant chemotherapy Prognostic biomarker
刊名EBIOMEDICINE
2018-09-01
DOI10.1016/j.ebiom.2018.08.042
35页:189-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]COLON-CANCER ; CIRCULATING MICRORNAS ; PROGNOSTIC BIOMARKER ; PLASMA MICRORNAS ; EARLY-DIAGNOSIS ; SURVIVAL ; PROTEIN ; MIR-21 ; CELLS
英文摘要

Background: Approximately 60% of patients with colorectal cancer (CRC) undergo either local recurrence or distant metastases after surgery. Current prognostic biomarkers are insufficient to predict recurrence of CRC and provide little forecast information about what patients are likely to receive benefit from the adjuvant chemotherapy. As microRNAs (miRNAs) constantly exist in human serum and being used to predict the prognosis of a various cancers, this study was designed to identify miRNA-based circulating biomarkers to predict clinical outcomes of CRC.

Methods: A serum-focused miRNA expression was used to investigate if miRNA expression profiles could predict the clinical outcomes of patients with CRC. We created miRNA signature profiles associated in the training set (n = 40), and further validated its prediction in two independent testing cohorts.

Results: Using Cox regression and risk-score analysis, we identified a four-miRNA signature (miR-652-3p, miR-342-3p, miR-501-3p and miR-328-3p) for the prediction of tumor relapse and the overall survival(05) of patients with CRC in the training set (n = 40). This miRNA signature was further validated in a testing set (n = 226) and another independent cohort (n = 56). A high-risk signature score was significantly associated with CRC tumor recurrence and poor treatment outcome. Multivariable Cox regression models indicated that the risk score, based on the four-miRNA signature, was an independent prognostic classifier for patients with CRC.

Conclusions: The scrum miRNA signature may serve as a minimally invasive predictor for tumor relapse and treatment outcome in patients with CRC and provide a useful reference for treatment selection. (C) 2018 The Authors. Published by Elsevier B.V.

语种英语
WOS记录号WOS:000445436400032
通讯作者邮箱zlguj@bjmu.edu.cn
第一作者单位Peking Univ, Dept Gastrointestinal Surg 3, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China
通讯作者单位Peking Univ, Dept Gastrointestinal Surg 3, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China ; Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China ; Peking Univ, SG Hosp, Beijing, Peoples R China
ISSN2352-3964
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145570
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Dept Gastrointestinal Surg 3, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China;
2.Zhejiang Univ, Key Lab Mol Biol Med Sci, Key Lab Canc Prevent & Intervent,Sch Med, Canc Inst,China Natl Minist Educ,Affiliated Hosp, Hangzhou 310009, Zhejiang, Peoples R China;
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China;
4.Peking Univ, SG Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ji, Dengbo,Qiao, Meng,Yao, Yunfeng,et al. Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients[J]. EBIOMEDICINE,2018,35:189-197.
APA Ji, Dengbo.,Qiao, Meng.,Yao, Yunfeng.,Li, Ming.,Chen, Hailong.,...&Gu, Jin.(2018).Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients.EBIOMEDICINE,35,189-197.
MLA Ji, Dengbo,et al."Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients".EBIOMEDICINE 35(2018):189-197.
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