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A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study
Liu, Hongwei1; Liu, Zhaojun2; Liu, Xue-wei3; Xu, Si1; Wang, Lei3; Liu, Yang1; Zhou, Jing2; Gu, Liankun2; Gao, Yan1; Liu, Xiao-yong3; Shi, Huidong4; Sun, Zheng3; Deng, Dajun2
通讯作者Sun, Zheng(3) ; Deng, Dajun(2)
关键词P16 Hydroxymethylation Oral epithelial dysplasia Malignant transformation Prospective cohort
刊名BMC CANCER
2018-09-24
DOI10.1186/s12885-018-4787-6
18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DNA METHYLATION ; CPG ISLANDS ; MAMMALIAN DNA ; HUMAN CANCERS ; 5-HYDROXYMETHYLCYTOSINE ; PROGRESSION ; MELANOMA ; 5-CARBOXYLCYTOSINE ; 5-METHYLCYTOSINE ; TRANSCRIPTION
英文摘要

Background: Total P16 methylation (P16M), including P16 hydroxymethylation (P16H) and true-P16M, correlates with malignant transformation of oral epithelial dysplasia (OED). Both true-P16M and P16H are early events in carcinogenesis. The aim of this study is to prospectively determine if discrimination of true-P16M from P16H is necessary for prediction of cancer development from OEDs.

Methods: Patients (n = 265) with mild or moderate OED were recruited into the double blind two-center cohort. Total-P16M and P16H were analyzed using the 115-bp MethyLight, TET-assisted bisulfite (TAB) methylation-specific PCR (MSP), and TAB-sequencing. Total-P16M-positive and P16H-negative samples were defined as true-P16M-positive. Progression of OEDs was monitored for a minimum 24 months follow-up period.

Results: P16H was detected in 23 of 73 (31.5%) total-P16M-positive OEDs. Follow-up information was obtained from 247 patients with an ultimate compliance rate of 93.2%. OED-derived squamous cell carcinomas were observed in 13.0% (32/247) patients during follow-up (median, 41.0 months). The cancer progression rate for total-P16M-positive patients was significantly increased when compared to total-P16M-negative patients [23.3% vs 8.6%; adjusted odds ratio = 2.67 (95% CI: 1.19-5.99)]. However, the cancer progression rates were similar between P16H-and true-P16M-positive OEDs [26.1% (6/23) vs 22.0% (11/50); odds ratio = 0.80 (95% CI: 0.22-2.92)]. The cancer-free survival was also similar for these patients.

Conclusion: P16H and true-P16M are similar biomarkers for determining malignant potential of OEDs. Discrimination of P16H from true-P16M, at least in OED, may be not necessary in clinical applications.

语种英语
WOS记录号WOS:000445491600006
通讯作者邮箱sunzheng12@vip.sohu.com ; dengdajun@bjmu.edu.cn
第一作者单位Peking Univ, Sch Stomatol, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing 100081, Peoples R China
通讯作者单位Peking Univ, Canc Hosp & Inst, Div Aetiol, Key Lab Carcinogenesis & Translat Res,MOE Beijing, Beijing 100142, Peoples R China ; Capital Med Univ, Sch Stomatol, Beijing 100050, Peoples R China
ISSN1471-2407
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145586
专题北京大学口腔医学院
北京大学口腔医学院_口腔黏膜科
北京大学临床肿瘤学院_病因学研究室
北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch Stomatol, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing 100081, Peoples R China;
2.Peking Univ, Canc Hosp & Inst, Div Aetiol, Key Lab Carcinogenesis & Translat Res,MOE Beijing, Beijing 100142, Peoples R China;
3.Capital Med Univ, Sch Stomatol, Beijing 100050, Peoples R China;
4.Augusta Univ, Med Coll Georgia, Georgia Canc Ctr, Augusta, GA 30912 USA
推荐引用方式
GB/T 7714
Liu, Hongwei,Liu, Zhaojun,Liu, Xue-wei,et al. A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study[J]. BMC CANCER,2018,18.
APA Liu, Hongwei.,Liu, Zhaojun.,Liu, Xue-wei.,Xu, Si.,Wang, Lei.,...&Deng, Dajun.(2018).A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study.BMC CANCER,18.
MLA Liu, Hongwei,et al."A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study".BMC CANCER 18(2018).
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