|Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer|
|Chen, Yi1; Li, Jinyu2; Zhang, Yibao3; Hu, Yi2; Zhang, Guoqing2; Yan, Xiang2; Lin, Zhi2; Zhao, Zhifei4; Jiao, Shunchang2,5|
|关键词||Small cell lung carcinoma Chemotherapy Radiotherapy Metastases Dose fractionation|
|刊名||STRAHLENTHERAPIE UND ONKOLOGIE|
|WOS标题词||Science & Technology|
|类目[WOS]||Oncology ; Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Oncology ; Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||COMPLETE REMISSION ; BRAIN METASTASES ; CARCINOMA ; SURVIVAL ; SURVEILLANCE ; MULTICENTER ; THERAPY ; DISEASE|
Previous studies demonstrated that prophylactic cranial irradiation (PCI) significantly reduced the incidence of brain metastases in patients with extensive disease small cell lung cancer (ED-SCLC). However, the appropriate timing for PCI in treating ED-SCLC is still unclear. This study aimed to compare the effect and safety of early versus late PCI.
Between November 2011 and July 2016, 103 patients with ED-SCLC were reviewed, receiving appropriate imaging tests to exclude brain metastases prior to cranial irradiation. Of these 103 patients, early PCI was performed in 47 patients and the other 56 patients received late PCI. The primary endpoint was the incidence of brain metastases. The progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were also assessed.
Early PCI significantly lowered the risk of brain metastases, as compared to late PCI (paEuro
To reduce the incidence of brain metastases, early PCI is more effective than late PCI for ED-SCLC patients.
|作者单位||1.Tsinghua Univ, Sch Clin Med, Beijing, Peoples R China;|
2.Chinese Peoples Liberat Army Gen Hosp, Dept Med Oncol, Beijing, Peoples R China;
3.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Radiotherapy,Minist Educ Beijing, Beijing, Peoples R China;
4.Chinese Peoples Liberat Army Gen Hosp, Dept Radiat Oncol, Beijing, Peoples R China;
5.28 Fu Xing Rd, Beijing 100853, Peoples R China
|Chen, Yi,Li, Jinyu,Zhang, Yibao,et al. Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer[J]. STRAHLENTHERAPIE UND ONKOLOGIE,2018,194(10):876-885.|
|APA||Chen, Yi.,Li, Jinyu.,Zhang, Yibao.,Hu, Yi.,Zhang, Guoqing.,...&Jiao, Shunchang.(2018).Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer.STRAHLENTHERAPIE UND ONKOLOGIE,194(10),876-885.|
|MLA||Chen, Yi,et al."Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer".STRAHLENTHERAPIE UND ONKOLOGIE 194.10(2018):876-885.|