IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤放疗科
学科主题临床医学
Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer
Chen, Yi1; Li, Jinyu2; Zhang, Yibao3; Hu, Yi2; Zhang, Guoqing2; Yan, Xiang2; Lin, Zhi2; Zhao, Zhifei4; Jiao, Shunchang2,5
通讯作者Jiao, Shunchang(2,5)
关键词Small cell lung carcinoma Chemotherapy Radiotherapy Metastases Dose fractionation
刊名STRAHLENTHERAPIE UND ONKOLOGIE
2018-10-01
DOI10.1007/s00066-018-1307-1
194期:10页:876-885
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]COMPLETE REMISSION ; BRAIN METASTASES ; CARCINOMA ; SURVIVAL ; SURVEILLANCE ; MULTICENTER ; THERAPY ; DISEASE
英文摘要

Previous studies demonstrated that prophylactic cranial irradiation (PCI) significantly reduced the incidence of brain metastases in patients with extensive disease small cell lung cancer (ED-SCLC). However, the appropriate timing for PCI in treating ED-SCLC is still unclear. This study aimed to compare the effect and safety of early versus late PCI.

Between November 2011 and July 2016, 103 patients with ED-SCLC were reviewed, receiving appropriate imaging tests to exclude brain metastases prior to cranial irradiation. Of these 103 patients, early PCI was performed in 47 patients and the other 56 patients received late PCI. The primary endpoint was the incidence of brain metastases. The progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were also assessed.

Early PCI significantly lowered the risk of brain metastases, as compared to late PCI (paEuro= 0.024). Additionally, multivariate analyses demonstrated that early PCI was a favorable independent predictor of the incidence of brain metastases. The PFS and OS of patients in the early and late PCI groups were comparable (PFS: 8.4 months vs. 7.5 months, paEuro0.753). The AEs were generally acceptable in both groups.

To reduce the incidence of brain metastases, early PCI is more effective than late PCI for ED-SCLC patients.

语种英语
WOS记录号WOS:000446123800002
通讯作者邮箱jiaosc_301pla@163.com
第一作者单位Tsinghua Univ, Sch Clin Med, Beijing, Peoples R China
通讯作者单位Chinese Peoples Liberat Army Gen Hosp, Dept Med Oncol, Beijing, Peoples R China ; 28 Fu Xing Rd, Beijing 100853, Peoples R China
ISSN0179-7158
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145593
专题北京大学临床肿瘤学院_肿瘤放疗科
作者单位1.Tsinghua Univ, Sch Clin Med, Beijing, Peoples R China;
2.Chinese Peoples Liberat Army Gen Hosp, Dept Med Oncol, Beijing, Peoples R China;
3.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Radiotherapy,Minist Educ Beijing, Beijing, Peoples R China;
4.Chinese Peoples Liberat Army Gen Hosp, Dept Radiat Oncol, Beijing, Peoples R China;
5.28 Fu Xing Rd, Beijing 100853, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yi,Li, Jinyu,Zhang, Yibao,et al. Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer[J]. STRAHLENTHERAPIE UND ONKOLOGIE,2018,194(10):876-885.
APA Chen, Yi.,Li, Jinyu.,Zhang, Yibao.,Hu, Yi.,Zhang, Guoqing.,...&Jiao, Shunchang.(2018).Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer.STRAHLENTHERAPIE UND ONKOLOGIE,194(10),876-885.
MLA Chen, Yi,et al."Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer".STRAHLENTHERAPIE UND ONKOLOGIE 194.10(2018):876-885.
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