IR@PKUHSC  > 北京大学公共卫生学院
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart, Symen1; Vaez, Ahmad2,3; Vosa, Urmo4,5; Stathopoulou, Maria G.6; de Vries, Paul S.1,7; Prins, Bram P.8; Van der Most, Peter J.2; Tanaka, Toshiko9; Naderi, Elnaz2,10; Rose, Lynda M.11; Wu, Ying12; Karlsson, Robert13; Barbalic, Maja14; Lin, Honghuang15; Pool, Rene16,17; Zhu, Gu18; Mace, Aurelien19,20,21; Sidore, Carlo22; Trompet, Stella23,24; Mangino, Massimo25,26; Sabater-Lleal, Maria27,28; Kemp, John P.29,30; Abbasi, Ali2,31,32; Kacprowski, Tim33,34,35; Verweij, Niek36; Smith, Albert V.37,38; Huang, Tao39,40; Marzi, Carola41,42; Feitosa, Mary F.43; Lohman, Kurt K.44; Kleber, Marcus E.45; Milaneschi, Yuri46,47; Mueller, Christian48,49,50; Huq, Mahmudul2; Vlachopoulou, Efthymia51; Lyytikainen, Leo-Pekka52,53; Oldmeadow, Christopher54,55; Deelen, Joris56,57; Perola, Markus58; Zhao, Jing Hua59; Feenstra, Bjarke60; Amini, Marzyeh2; Lahti, Jari61,62,63; Schraut, Katharina E.64; Fornage, Myriam65,66; Suktitipat, Bhoom67; Chen, Wei-Min68; Li, Xiaohui69; Nutile, Teresa70; Malerba, Giovanni71; Luan, Jian′ an59; Bak, Tom72; Schork, Nicholas73,74; Del Greco, Fabiola M.75; Thiering, Elisabeth76,77; Mahajan, Anubha78; Marioni, Riccardo E.79,80; Mihailov, Evelin5; Eriksson, Joel81; Ozel, Ayse Bilge82; Zhang, Weihua83,84; Nethander, Maria85; Cheng, Yu-Ching86; Aslibekyan, Stella87; Ang, Wei88; Gandin, Ilaria89; Yengo, Loic90,91; Portas, Laura92; Kooperberg, Charles93; Hofer, Edith94,95; Rajan, Kumar B.96; Schurmann, Claudia97,98; den Hollander, Wouter99; Ahluwalia, Tarunveer S.100,101; Zhao, Jing102; Draisma, Harmen H. M.16,17,103; Ford, Ian104; Timpson, Nicholas30; Teumer, Alexander105; Huang, Hongyan106; Wahl, Simone41,42; Liu, YongMei44; Huang, Jie107; Uh, Hae-Won108; Geller, Frank60; Joshi, Peter K.64; Yanek, Lisa R.109; Trabetti, Elisabetta71; Lehne, Benjamin83; Vozzi, Diego110; Verbanck, Marie90; Biino, Ginevra111; Saba, Yasaman112; Meulenbelt, Ingrid99; O′ Connell, Jeff R.86; Laakso, Markku113,114; Giulianini, Franco11; Magnusson, Patrik K. E.13; Ballantyne, Christie M.115,116; Hottenga, Jouke Jan16; Montgomery, GrantW.18; Rivadineira, Fernando117; Rueedi, Rico19,20; Steri, Maristella22; Herzig, Karl-Heinz118,119,120,121; Stott, David J.122; Menni, Cristina25; Franberg, Mattias28,123; St Pourcain, Beate30,124; Felix, Stephan B.35,125; Pers, Tune H.60,101; Bakker, Stephan J. L.31; Kraft, Peter106; Peters, Annette126; Vaidya, Dhananjay109; Delgado, Graciela45; Smit, Johannes H.46,47; Grossmann, Vera127; Sinisalo, Juha128,129; Seppala, Ilkka52,53; Williams, Stephen R.130; Holliday, Elizabeth G.54,55; Moed, Matthijs56; Langenberg, Claudia59; Raikkonen, Katri62; Ding, Jingzhong131; Campbell, Harry64; Sale, Michele M.68; Chen, Yii-Der I.69; James, Alan L.132,133; Ruggiero, Daniela70,134; Soranzo, Nicole135; Hartman, Catharina A.72; Smith, Erin N.136,137; Berenson, Gerald S.138; Fuchsberger, Christian75; Hernandez, Dena139,140; Tiesler, Carla M. T.76,77; Giedraitis, Vilmantas140; Liewald, David79; Fischer, Krista5; Mellstrom, Dan81; Larsson, Anders141; Wang, Yunmei142; Scott, William R.83; Lorentzon, Matthias81,143; Beilby, John144,145; Ryan, Kathleen A.86; Pennell, Craig E.88; Vuckovic, Dragana146; Balkau, Beverly147; Concas, Maria Pina110; Schmidt, Reinhold94; de Leon, Carlos F. Mendes148; Bottinger, Erwin P.97,149; Kloppenburg, Margreet150,151; Paternoster, Lavinia30; Boehnke, Michael152,153; Musk, A. W.132,154; Willemsen, Gonneke16; Evans, David M.29,30; Madden, Pamela A. F.155; Kahonen, Mika156,157; Kutalik, Zoltan20,21; Zoledziewska, Magdalena22; Karhunen, Ville158; Kritchevsky, Stephen B.159; Sattar, Naveed160; Lachance, Genevieve25; Clarke, Robert161; Harris, Tamara B.162; Raitakari, Olli T.163,164; Attia, John R.54,55,165; Van Heemst, Diana24; Kajantie, Eero166,167,168,169,170; Sorice, Rossella70; Gambaro, Giovanni171; Scott, Robert A.59; Hicks, Andrew A.75; Ferrucci, Luigi9; Standl, Marie76; Lindgren, Cecilia M.78,172,173; Starr, John M.79,174; Karlsson, Magnus175; Lind, Lars141; Li, Jun Z.82; Chambers, John C.83,84,176,177,178; Mori, Trevor A.88; de Geus, Eco J. C. N.16,17; Heath, Andrew C.155; Martin, Nicholas G.18; Auvinen, Juha158,179; Buckley, Brendan M.180; de Craen, Anton J. M.24; Waldenberger, Melanie41,181; Strauch, Konstantin182,183; Meitinger, Thomas184,185,186; Scott, Rodney J.54,187; McEvoy, Mark54,55; Beekman, Marian56; Bombieri, Cristina71; Ridker, Paul M.11,188; Mohlke, Karen L.12; Pedersen, Nancy L.13; Morrison, Alanna C.7; Boomsma, Dorret I.16; Whitfield, John B.18; Strachan, David P.189; Hofman, Albert1; Vollenweider, Peter190; Cucca, Francesco22; Jarvelin, Marjo-Riitta120,158,179,191,192; Jukema, J. Wouter23,193,194; Spector, Tim D.25; Hamsten, Anders28; Zeller, Tanja48,50; Uitterlinden, Andre G.117; Nauck, Matthias35,195; Gudnason, Vilmundur37,38; Qi, Lu40,196; Grallert, Harald41,42; Borecki, Ingrid B.197; Rotter, Jerome I.198,199; Maerz, Winfried45,200,201; Wild, Philipp S.50,127,202; Lokki, Marja-Liisa51; Boyle, Michael165; Salomaa, Veikko58; Melbye, Mads60,203,204; Eriksson, Johan G.58,63,205,206; Wilson, James F.64,207; Penninx, Brenda W. J. H.46,47; Becker, Diane M.109; Worrall, Bradford B.208,209; Gibson, Greg102; Krauss, Ronald M.210; Ciullo, Marina70,134; Zaza, Gianluigi211; Wareham, Nicholas J.59; Oldehinkel, Albertine J.72; Palmer, Lyle J.212; Murray, Sarah S.213; Pramstaller, Peter P.75,214,215; Bandinelli, Stefania216; Heinrich, Joachim76,217; Ingelsson, Erik218,219,220; Deary, Ian J.79,221; Magi, Reedik5; Vandenput, Liesbeth81; van der Harst, Pim36; Desch, Karl C.222; Kooner, Jaspal S.84,176,178,223; Ohlsson, Claes81; Hayward, Caroline207; Lehtimaki, Terho52,53; Shuldiner, Alan R.86; Arnett, Donna K.224; Beilin, Lawrence J.88; Robino, Antonietta110; Froguel, Philippe90,225; Pirastu, Mario92; Jess, Tine226; Koenig, Wolfgang181,227,228; Loos, Ruth J. F.97,98,229; Evans, Denis A.96; Schmidt, Helena230,231; Smith, George Davey30; Slagboom, P. Eline56; Eiriksdottir, Gudny37; Morris, Andrew P.78,232; Psaty, Bruce M.233,234,235,236; Tracy, Russell P.237; Nolte, Ilja M.2; Boerwinkle, Eric238,239; Visvikis-Siest, Sophie6; Reiner, Alex P.234; Gross, Myron240; Bis, Joshua C.233; Franke, Lude4; Franco, Oscar H.1,241; Benjamin, Emelia J.15,242; Chasman, Daniel I.11,188; Dupuis, Josee242,243; Snieder, Harold2; Dehghan, Abbas1,191; Alizadeh, Behrooz Z.2; LifeLines Cohort Study2; CHARGE Inflammation Working Grp(); Dehghan, Abbas(1,191); Alizadeh, Behrooz Z.(2)
Source PublicationAMERICAN JOURNAL OF HUMAN GENETICS
2018-11-01
ISSN0002-9297
Volume103Issue:5Pages:691-706
Indexed BySCI
Abstract

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 x 10(-8)). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.

Subject Area公共卫生
SubtypeArticle
DOI10.1016/j.ajhg.2018.09.009
WOS HeadingsScience & Technology
Language英语
WOS Research AreaGenetics & Heredity ; Genetics & Heredity
WOS SubjectGenetics & Heredity
WOS KeywordC-REACTIVE PROTEIN ; CORONARY-HEART-DISEASE ; LD SCORE REGRESSION ; MENDELIAN RANDOMIZATION ; WIDE ASSOCIATION ; SCHIZOPHRENIA ; INSTRUMENTS ; EPIDEMIOLOGY ; METAANALYSIS ; IMMUNITY
WOS IDWOS:000448942100006
Correspondent Emaila.dehghan@imperial.ac.uk ; b.z.alizadeh@umcg.nl
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/149696
Collection北京大学公共卫生学院
Corresponding AuthorDehghan, Abbas(1,191); Alizadeh, Behrooz Z.(2)
Affiliation1.Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands;
2.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands;
3.Isfahan Univ Med Sci, Dept Bioinformat, Esfahan 8174673461, Iran;
4.Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands;
5.Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia;
6.Univ Lorraine, INSERM, IGE PCV, F-54000 Nancy, France;
7.Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Ctr Human Genet, Houston, TX 77030 USA;
8.Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton CB10 1SA, England;
9.NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA;
10.Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, NL-9713 GZ Groningen, Netherlands;
11.Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA;
12.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden;
13.Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands;
14.Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, NL-1081 BT Amsterdam, Netherlands;
15.QIMR Berghofer Med Res Inst, Brisbane, Qld 4006, Australia;
16.Univ Lausanne, Dept Computat Biol, CH-1010 Lausanne, Switzerland;
17.Univ Hosp Lausanne, Inst Social & Prevent Med, CH-1010 Lausanne, Switzerland;
18.CNR, Ist Ric Genet & Biomed, I-08045 Sardinia, Italy;
19.Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands;
20.Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2333 ZA Leiden, Netherlands;
21.Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England;
22.Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England;
23.Inst Invest Biomed St Pau, Unit Genom Complex Dis, Barcelona 08025, Spain;
24.Karolinska Inst, Ctr Mol Med, Cardiovasc Med Unit, Dept Med, S-17176 Stockholm, Sweden;
25.Univ Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld 4102, Australia;
26.Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England;
27.Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9713 GZ Groningen, Netherlands;
28.Univ Cambridge, Sch Med, Inst Metab Sci, MRC,Epidemiol Unit,Addenbrookes Hosp, Cambridge Biomed Campus, Cambridge CB2 0QQ, England;
29.Univ Med, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany;
30.Iceland Heart Assoc, IS-201 Kopavogur, Iceland;
31.Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland;
32.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA;
33.German Ctr Diabet Res, Partner Site Munich, D-85764 Munich, Germany;
34.Ernst Moritz Arndt Univ Greifswald, D-17475 Greifswald, Germany;
35.German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;
36.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands;
37.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China;
38.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany;
39.Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63108 USA;
40.Wake Forest Univ Hlth Sci, Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA;
41.Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68167 Mannheim, Germany;
42.Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Dept Psychiat,Amsterdam Neurosci, NL-1081 HJ Amsterdam, Netherlands;
43.Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Amsterdam Publ Hlth Res Inst, NL-1081 HJ Amsterdam, Netherlands;
44.Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, D-20246 Hamburg, Germany;
45.Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Campus Luebeck, D-23562 Lubeck, Germany;
46.German Ctr Cardiovasc Res, Partner Site RhineMain, D-55131 Mainz, Germany;
47.Univ Helsinki, Transplantat Lab, Medicum, FIN-00014 Helsinki, Finland;
48.Fimlab Labs, Dept Clin Chem, Tampere 33014, Finland;
49.Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33520, Finland;
50.Hunter Med Res Inst, New Lambon Hts, NSW 2305, Australia;
51.Univ Newcastle, Fac Hlth & Med, Ctr Clin Epidemiol & Biostat, Callaghan, NSW 2308, Australia;
52.Leiden Univ, Med Ctr, Mol Epidemiol, NL-2333 ZC Leiden, Netherlands;
53.Max Planck Inst Biol Ageing, D-50931 Cologne, Germany;
54.Natl Inst Hlth & Welf, Helsinki 00271, Finland;
55.Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England;
56.Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark;
57.Univ Helsinki, Helsinki Coll Adv Studies, FIN-00014 Helsinki, Finland;
58.Univ Helsinki, Fac Med, Dept Psychol & Logoped, FIN-00014 Helsinki, Finland;
59.Folkhalsan Res Ctr, Helsinki 00250, Finland;
60.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH16 4UX, Midlothian, Scotland;
61.J Craig Venter Inst, Human Biol, La Jolla, CA 92037 USA;
62.Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England;
63.AREA Sci Pk, I-34149 Trieste, Italy;
64.Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA;
65.Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA;
66.Mahidol Univ, Siriraj Hosp, Fac Med, Dept Biochem, Bangkok 10700, Thailand;
67.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA;
68.Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA;
69.CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy;
70.Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy;
71.Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 RB Groningen, Netherlands;
72.Translat Genom Res Inst, Quantitat Med, Phoenix, AZ 85004 USA;
73.Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, I-39100 Bolzano, Italy;
74.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany;
75.Ludwig Maximilian Univ Munich, Dr von Hauner Childrens Hosp, D-80337 Munich, Germany;
76.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England;
77.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland;
78.Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland;
79.Univ Gothenburg, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden;
80.Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA;
81.UCL, Dept Epidemiol & Biostat, London W2 1PG, England;
82.Univ Gothenburg, Sahlgrenska Acad, Bioinformat Core Facil, S-41390 Gothenburg, Sweden;
83.Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA;
84.Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA;
85.Univ Western Australia, Sch Med, Perth, WA 6009, Australia;
86.Univ Lille, Inst Pasteur Lille, European Genom Inst Diabet, CNRS,UMR 8199,FR 3508, F-59000 Lille, France;
87.Univ Queensland, Inst Mol Biosci, Program Complex Trait Genom, Brisbane, Qld 4072, Australia;
88.CNR, Inst Genet & Biomed Res, Support OU, I-7100 Sassari, Italy;
89.Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Mail Stop M3-A410,1100 Fairview Ave N, Seattle, WA 98104 USA;
90.Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, A-8036 Graz, Austria;
91.Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria;
92.Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA;
93.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;
94.Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA;
95.Leiden Univ, Med Ctr, Sect Mol Epidemiol, Dept Med Stat & Bioinformat, NL-2333 ZC Leiden, Netherlands;
96.Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark;
97.Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Sect Metab Genet,Fac Hlth & Med Sci, DK-2100 Copenhagen, Denmark;
98.Georgia Inst Technol, Sch Biol, Ctr Integrat Genom, Atlanta, GA 30332 USA;
99.Neurosci Campus Amsterdam, NL-1081 HV Amsterdam, Netherlands;
100.Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland;
101.Boston VA Res Inst Inc, Boston, MA 02130 USA;
102.Gottfried Schatz Res Ctr, Inst Mol Biol & Biochem, A-8010 Graz, Austria;
103.Kuopio Univ Hosp, Kuopio 70210, Finland;
104.Baylor Coll Med, Dept Med, Houston, TX 77030 USA;
105.Univ Med Greifswald, Inst Community Med, Dept SHIP KEF, D-17475 Greifswald, Germany;
106.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA;
107.Leiden Univ, Med Ctr, Med Stat & Bioinformat, NL-2333 ZC Leiden, Netherlands;
108.Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21287 USA;
109.IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34140 Trieste, Italy;
110.CNR, Inst Mol Genet, I-27100 Pavia, Italy;
111.Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio 70210, Finland;
112.Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA;
113.Erasmus Univ, Med Ctr, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands;
114.Univ Oulu, Med Res Ctr Oulu, Dept Physiol, Inst Biomed, Oulu 90014, Finland;
115.Poznan Univ Med Sci, Dept Gastroenterol & Metab, PL-60512 Poznan, Poland;
116.Univ Glasgow, Fac Med, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland;
117.Stockholm Univ, Dept Numer Anal & Comp Sci, S-10044 Stockholm, Sweden;
118.Radboud Univ Nijmegen, Donders Inst, NL-6525 XD Nijmegen, Netherlands;
119.Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany;
120.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, D-85764 Neuherber, Germany;
121.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, D-55131 Mainz, Germany;
122.Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki 00029, Finland;
123.Wake Forest Univ Hlth Sci, Dept Internal Med Geriatr, Winston Salem, NC 27157 USA;
124.Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA 6009, Australia;
125.Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA 6009, Australia;
126.Univ Calif San Diego, Dept Pediat, Sch Med, La Jolla, CA 92037 USA;
127.Univ Calif San Diego, Rady Childrens Hosp, Sch Med, La Jolla, CA 92037 USA;
128.NIA, Neurogenet Lab, Bethesda, MD 20892 USA;
129.Uppsala Univ, Dept Publ Hlth & Caring Sci, Mol Geriatr, S-75237 Uppsala, Sweden;
130.Case Western Reserve Univ, Case Cardiovasc Res Inst, Dept Med, Harrington Heart & Vasc Inst,Univ Hosp, Cleveland, OH 44106 USA;
131.Sahlgrens Univ Hosp, Geriatr Med, S-43180 Molndal, Sweden;
132.Univ Western Australia, Sch Biomed Sci, Perth, WA 6009, Australia;
133.Univ Trieste, Med Sci Surg & Hlth Dept, I-34137 Trieste, Italy;
134.Univ Paris Saclay, Univ Versailles St Quentin En Yvelines, Team EpReC Renal & Cardiovasc Epidemiol 5, INSERM,U1018,Ctr Rech Epidemiol & Sante Populat, F-94807 Villejuif, France;
135.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA;
136.Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA;
137.Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands;
138.Leiden Univ, Med Ctr, Dept Clin Epidemiol, NL-2333 ZC Leiden, Netherlands;
139.Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;
140.Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA;
141.Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA 6009, Australia;
142.Washington Univ, Sch Med, Dept Psychiat, 4560 Clayton Ave,Suite 1000, St Louis, MO 63110 USA;
143.Tampere Univ Hosp, Dept Clin Physiol, Tampere 33520, Finland;
144.Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere 33520, Finland;
145.Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu 90014, Finland;
146.Wake Forest Univ Hlth Sci, Sticht Ctr Aging & Rehabil, Gerontol & Geriatr Med, Winston Salem, NC 27157 USA;
147.John Hunter Hosp, New Lambton Hts, NSW 2305, Australia;
148.Univ Helsinki, FIN-00290 Helsinki, Finland;
149.BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow G12 8TA, Lanark, Scotland;
150.Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England;
151.NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA;
152.Turku Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-20520 Turku, Finland;
153.Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland;
154.Natl Inst Hlth & Welf, Chron Dis Prevent Unit, Helsinki 00014, Finland;
155.Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, FIN-00290 Helsinki, Finland;
156.Oulu Univ Hosp, MRC Oulu, Dept Obstet & Gynaecol, Oulu 90014, Finland;
157.Univ Cattolica Sacro Cuore, Columbus Gemelli Univ Hosp, Div Nephrol & Dialysis, I-168 Rome, Italy;
158.Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford OX3 7FZ, England;
159.Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA;
160.Univ Edinburgh, Alzheimers Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland;
161.Lund Univ, Dept Clin Sci & Orthopaed Surg, S-20502 Malmo, Sweden;
162.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore;
163.Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England;
164.Oulu Univ Hosp, Unit Primary Hlth Care, Oulu 90220, Finland;
165.Univ Coll Cork, Dept Epidemiol & Publ Hlth, Cork T12 K8AF, Ireland;
166.German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80636 Munich, Germany;
167.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany;
168.Ludwig Maximilian Univ Munich, Fac Med, Inst Med Informat Biometry & Epidemiol, Genet Epidemiol, D-85764 Neuherberg, Germany;
169.Tech Univ Munich, Inst Human Genet, D-85764 Munich, Germany;
170.Helmholtz Zentrum Munchen, Inst Human Genet, D-85764 Neuherberg, Germany;
171.Munich Cluster Syst Neurol SyNergy, D-81377 Munich, Germany;
172.Hunter Med Res Inst, Informat Based Med Stream, New Lambton Hts, NSW 2305, Australia;
173.Harvard Med Sch, Boston, MA 02115 USA;
174.St Georges Univ London, Populat Hlth Res Inst, London SW17 0RE, England;
175.Durrer Ctr Cardiogenet Res, NL-3501 DG Amsterdam, Netherlands;
176.Synlab Holding Deutschland GmbH, Synlab Acad, D-68161 Mannheim, Germany;
177.Univ Copenhagen, Dept Clin Med, DK-2300 Copenhagen, Denmark;
178.CHU Vaudois, Dept Internal Med, CH-1011 Lausanne, Switzerland;
179.Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London W2 1PG, England;
180.Brunel Univ London, Coll Hlth & Life Sci, Dept Life Sci, Kingston Lane, Uxbridge UB8 3PH, Middx, England;
181.Interuniv Cardiol Inst Netherlands, NL-3511 EP Utrecht, Netherlands;
182.Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany;
183.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA;
184.Regeneron Pharmaceut Inc, Regeneron Genet Ctr, Analyt Genet Grp, Tarrytown, NY 10591 USA;
185.Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90502 USA;
186.Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Med, Torrance, CA 90502 USA;
187.Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria;
188.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Prevent Cardiol & Prevent Med, D-55131 Mainz, Germany;
189.Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FIN-00014 Helsinki, Finland;
190.Helsinki Univ Hosp, Helsinki 00014, Finland;
191.Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland;
192.Univ Virginia Charlottesville, Dept Neurol, Charlottesville, VA 22908 USA;
193.Univ Virginia Charlottesville, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA;
194.Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA;
195.Verona Univ Hosp, Dept Med, Renal Unit, I-37126 Verona, Italy;
196.Univ Calif San Diego, Dept Pathol, San Diego, CA 92121 USA;
197.Azienda Sanit Firenze, Geriatr Unit, I-50122 Florence, Italy;
198.Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Comprehens Pneumol Ctr Munich,DZL,German Ctr Lung, D-81377 Munich, Germany;
199.Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, S-75141 Uppsala, Sweden;
200.Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA;
201.Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;
202.Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland;
203.Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA;
204.Imperial Coll London, Natl Heart & Lung Inst, London W12 0NN, England;
205.Univ Kentucky, Coll Publ Hlth, Lexington, KY 40508 USA;
206.Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London SW7 2AZ, England;
207.Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, DK-2200 Frederiksberg, Denmark;
208.Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-80801 Ulm, Germany;
209.Tech Univ Munich, Deutsch Herzzentrum Muchen, D-80636 Munich, Germany;
210.Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA;
211.Med Univ Graz, Dept Neurol, A-8010 Graz, Austria;
212.Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, A-8010 Graz, Austria;
213.Univ Liverpool, Dept Biostat, Liverpool L69 3GL, Merseyside, England;
214.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA;
215.Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA;
216.Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA;
217.Kaiser Permanente Washington Hlth Res Inst, Seattle, WA 98101 USA;
218.Univ Vermont, Dept Pathol, Burlington, VT 05405 USA;
219.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA;
220.Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA;
221.Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA;
222.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA;
223.Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland;
224.Natl Heart Lung & Blood Inst, Framingham Heart Study, Framingham, MA 01702 USA;
225.Univ Split, Sch Med, Split 21000, Croatia;
226.Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA;
227.Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA;
228.Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland;
229.Oulu Univ Hosp, Oulu 90014, Finland;
230.Univ Oulu, Bioctr Oulu, SF-90220 Oulu, Finland;
231.Univ Helsinki, Helsinki 00029, Finland;
232.Univ Virginia, Dept Neurol, Charlottesville, VA 22908 USA;
233.IRCCS Neuromed, I-86077 Pozzilli, IS, Italy;
234.Sanger Inst, Wellcome Trust Genome Campus, Hinxton CB10 1SA, England;
235.Tulane Univ, Ctr Cardiovasc Hlth, New Orleans, LA 70112 USA;
236.Uppsala Univ, Dept Med Sci, S-75141 Uppsala, Sweden;
237.PathWest Lab Med WA, Nedlands, WA 6009, Australia;
238.Univ Oulu, Oulu 90014, Finland;
239.Imperial Coll Healthcare NHS Trust, London W12 0HS, England;
240.Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA;
241.Univ Adelaide, Sch Publ Hlth, Adelaide, SA 5000, Australia;
242.Gen Cent Hosp, Dept Neurol, I-39100 Bolzano, Italy;
243.Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany
Recommended Citation
GB/T 7714
Ligthart, Symen,Vaez, Ahmad,Vosa, Urmo,et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2018,103(5):691-706.
APA Ligthart, Symen.,Vaez, Ahmad.,Vosa, Urmo.,Stathopoulou, Maria G..,de Vries, Paul S..,...&Alizadeh, Behrooz Z..(2018).Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.AMERICAN JOURNAL OF HUMAN GENETICS,103(5),691-706.
MLA Ligthart, Symen,et al."Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders".AMERICAN JOURNAL OF HUMAN GENETICS 103.5(2018):691-706.
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