IR@PKUHSC  > 北京大学公共卫生学院  > 流行病与卫生统计学系
Associations of autozygosity with a broad range of human phenotypes
Wareham, Nicholas J.12; Wild, Sarah249; Yajnik, Chittaranjan S.250; Yuan, Jian-Min251; Zeng, Lingyao1; Zhang, Liang117; Zhou, Jie84; Amin, Najaf22; Asselbergs, Folkert W.252,253,254,255,256; Bakker, Stephan J. 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Source PublicationNATURE COMMUNICATIONS
2019-10-31
ISSN2041-1723
Volume10
Indexed BySCI
Abstract

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.

KeywordINBREEDING DEPRESSION HOMOZYGOSITY FERTILITY LOCI RUNS QUANTIFICATION
Subject Area公共卫生
SubtypeArticle
DOI10.1038/s41467-019-12283-6
WOS HeadingsScience & Technology
Language英语
Funding OrganizationUK Medical Research Council Human Genetics Unit ; MRC
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000493438700005
Correspondent Emailjim.wilson@ed.ac.uk
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/159783
Collection北京大学公共卫生学院_流行病与卫生统计学系
Affiliation1.Hlth Data Res UK London, London, England;
2.Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore 169857, Singapore;
3.Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland;
4.Natl Def Med Ctr, Sch Med, Taipei, Taiwan;
5.Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto 6068507, Japan;
6.Univ Split, Ctr Global Hlth, Fac Med, Split, Croatia;
7.Kuopio Univ Hosp, Kuopio, Finland;
8.Bristol NIHR Biomed Res Ctr, Bristol BS8 2BN, Avon, England;
9.Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan;
10.Chung Shan Med Univ, Sch Med, Taichung 402, Taiwan;
11.Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan;
12.Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland;
13.German Ctr Diabet Res DZD, Munich, Germany;
14.Univ Dundee, Ninewells Hosp, Med Res Inst, Dundee, Scotland;
15.Univ Dundee, Sch Med, Dundee, Scotland;
16.Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland;
17.Area Sci Pk, Res Unit, I-34149 Trieste, Italy;
18.Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy;
19.Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland;
20.Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Osaka 5650871, Japan;
21.RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan;
22.Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Suita, Osaka 5650871, Japan;
23.Bradford Teaching Hosp NHS Trust, Bradford Inst Hlth Res, Bradford BD9 6RJ, W Yorkshire, England;
24.Natl Inst Hlth & Welf, Unit Publ Hlth Solut, Helsinki, Finland;
25.Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England;
26.Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England;
27.Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;
28.Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands;
29.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA;
30.Ichan Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;
31.Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA;
32.Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA;
33.Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England;
34.Ealing Gen Hosp, Dept Cardiol, Middlesex UB1 3HW, England;
35.Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands;
36.Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands;
37.Erasmus MC, Generat R Study Grp, NL-3015 CN Rotterdam, Netherlands;
38.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden;
39.Univ Essex, Inst Social & Econ Res, Colchester CO4 3SQ, Essex, England;
40.Univ Washington, Dept Biostat & Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA;
41.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany;
42.Natl Res Council Italy, Inst Mol Genet, I-27100 Pavia, Italy;
43.Univ Otago, Dept Biochem, Dunedin 9054, New Zealand;
44.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore;
45.Univ Lausanne, Dept Computat Biol, CH-1011 Lausanne, Switzerland;
46.Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland;
47.Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland;
48.ICAN Inst Cardiometab & Nutr, F-75013 Paris, France;
49.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA;
50.Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA;
51.Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA;
52.Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3584 CX Utrecht, Netherlands;
53.Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Genom Res Ctr, Brisbane, Qld 4059, Australia;
54.Malaghan Inst Med Res, Wellington 6242, New Zealand;
55.Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, I-39100 Bolzano, Italy;
56.Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England;
57.Sorbonne Univ, INSERM, UMR S 1166, F-75013 Paris, France;
58.QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia;
59.Leiden Univ, Dept Clin Epidemiol, Med Ctr, NL-2333 ZA Leiden, Netherlands;
60.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland;
61.Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland;
62.Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, A-8036 Graz, Austria;
63.Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria;
64.CONACyT, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 03940, DF, Mexico;
65.Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Complex Trait Genet, NL-1081 HV Amsterdam, Netherlands;
66.Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Dept Neurol, Amsterdam Neurosci, NL-1081 HV Amsterdam, Netherlands;
67.Univ Med Greifswald, Interfaculty Inst Genet & Funct Genom, D-17475 Greifswald, Germany;
68.Tech Univ Munich, TUM Sch Life Sci Weihenstephan, Chair Expt Bioinformat, D-85354 Freising Weihenstephan, Germany;
69.Uppsala Univ, Sci Life Lab, Dept Immunol Genet & Pathol, S-75108 Uppsala, Sweden;
70.Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabeto, D-68167 Mannheim, Germany;
71.Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD USA;
72.Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England;
73.Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Tokyo 1088639, Japan;
74.German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany;
75.Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA;
76.Univ Maryland, Sch Med, Dept Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA;
77.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands;
78.Univ Lubeck, Inst Cardiogenet, D-23562 Lubeck, Germany;
79.DZHK German Res Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, D-23562 Lubeck, Germany;
80.Univ Heart Ctr Luebeck, D-23562 Lubeck, Germany;
81.Charite Univ Med Berlin, Berlin, Germany;
82.Free Univ Berlin, Berlin, Germany;
83.Humboldt Univ, Berlin, Germany;
84.Berlin Inst Hlth, Berlin, Germany;
85.Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany;
86.CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy;
87.Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland;
88.CSIR Inst Genom & Integrat Biol, Genom & Mol Med Unit, New Delhi 110020, India;
89.Lund Univ, Skane Univ Hosp, Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, S-20502 Malmo, Sweden;
90.EPhood SRL, EPhood Sci Unit, I-20091 Milan, Italy;
91.Univ Milan, Dept Hlth Sci, I-20139 Milan, Italy;
92.Iceland Heart Assoc, IS-201 Kopavogur, Iceland;
93.CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad 500007, Telangana, India;
94.IRCCS Fdn Carlo Besta Neurol Inst, Neuroalgol Unit, I-20133 Milan, Italy;
95.Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat, Oklahoma City, OK 73104 USA;
96.NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA;
97.Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark;
98.Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland;
99.Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA;
100.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8RZ, Lanark, Scotland;
101.Karolinska Inst, Ctr Mol Med, Dept Med Solna, Cardiovasc Med Unit, S-17176 Stockholm, Sweden;
102.NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA;
103.Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands;
104.Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, NL-2300 RC Leiden, Netherlands;
105.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;
106.Univ Bern, ISPM, Bern, Switzerland;
107.Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo 1088639, Japan;
108.Lab Neurogenet, Bethesda, MD 20892 USA;
109.Data Tecn Int LLC, Glen Echo, MD 20812 USA;
110.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA;
111.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 GZ Groningen, Netherlands;
112.Univ Turin, IIGM, I-10126 Turin, Italy;
113.Univ Turin, Dept Med Sci, I-10126 Turin, Italy;
114.Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA;
115.Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Ctr, London EC1M 6BQ, England;
116.Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Dept Clin Pharmacol, London EC1M 6BQ, England;
117.Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England;
118.Univ Bristol, Sch Psychol Sci, Bristol BS8 1TU, Avon, England;
119.Johns Hopkins Univ, Sch Med, GeneSTAR Res Program, Dept Med, Baltimore, MD 21287 USA;
120.Weill Cornell Med Qatar, Dept Genet Med, Doha, Qatar;
121.Alexandria Univ, Comp & Syst Engn, Alexandria, Egypt;
122.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA;
123.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Mexico City, DF 14080, Mexico;
124.INSERM, U1223, F-75015 Paris, France;
125.Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia;
126.Escuela Med & Ciencias Salud, Tecnol Monterrey, Unidad Invest Enfermades Metabol, Monterrey 64710, NL, Mexico;
127.Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Fukuoka 8128582, Japan;
128.Inst Pasteur, Immunobiol Dendrit Cells, F-75015 Paris, France;
129.Inst Pasteur, Ctr Translat Res, F-75015 Paris, France;
130.Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA;
131.UC San Diego Sch Med, Dept Family Med & Publ Hlth, Div Prevent Med, La Jolla, CA 92093 USA;
132.Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore;
133.Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore;
134.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore;
135.Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran 1983963113, Iran;
136.German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany;
137.Univ Texas Houston, UTHlth Sch Publ Hlth, Hlth Sci Ctr Houston, Houston, TX 77030 USA;
138.Univ San Carlos, USC Off Populat Studies Fdn Inc, Dept Nutr & Dietet, Cebu 6000, Cebu, Philippines;
139.Inst Nacl Med Genom, Mexico City 14610, DF, Mexico;
140.Gen Info Ltd, Zagreb 10000, Croatia;
141.CNRS, UMR2000, F-75015 Paris, France;
142.Univ Utrecht, Univ Med Ctr Utrecht, Div Surg Specialties, Dept Vasc Surg, NL-3584 CX Utrecht, Netherlands;
143.Univ Potsdam, Hasso Plattner Inst, Digital Hlth Ctr, D-14482 Potsdam, Germany;
144.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;
145.Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli, Taiwan;
146.IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy;
147.NHGRI, NIH, Bethesda, MD 20892 USA;
148.Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland;
149.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore;
150.Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA;
151.Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran 1983963113, Iran;
152.Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA;
153.Univ Dundee, MEMO Res Mol & Clin Med, Dundee DD1 9SY, Scotland;
154.Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany;
155.DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;
156.Univ Iceland, Dept Anthropol, IS-101 Reykjavik, Iceland;
157.Imperial Coll London, London, England;
158.Imperial Coll London, UK DRI, London, England;
159.King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 12713, Saudi Arabia;
160.Imperial Coll Healthcare NHS Trust, Imperial Biomed Res Ctr, Natl Inst Hlth Res, London, England;
161.Erasmus MC, Dept Pediat, NL-3015 CN Rotterdam, Netherlands;
162.Wake Forest Sch Med, Dept Internal Med, Sect Nephrol, Winston Salem, NC 27101 USA;
163.IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Med Genet, Trieste, Italy;
164.Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX3 9DU, England;
165.Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA;
166.Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel;
167.Chinese Acad Med Sci, Beijing 100730, Peoples R China;
168.Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England;
169.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA;
170.Queen Mary Univ London, Blizard Inst, London E1 2AT, England;
171.Univ Tokyo, Inst Med Sci, Lab Genome Technol, Tokyo 1088639, Japan;
172.Univ Utrecht, Univ Med Ctr Utrecht, Div Labs & Pharm, Lab Clin Chem & Hematol, NL-3584 CX Utrecht, Netherlands;
173.Folkhalsan Res Ctr, Helsinki, Finland;
174.Vasa Cent Hosp, Vaasa, Finland;
175.Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, State Key Lab Med Genom,Shanghai Inst Hematol, Shanghai 200025, Peoples R China;
176.Triserv Gen Hosp, Div Endocrine & Metab, Songshan Branch, Taipei, Taiwan;
177.Natl Inst Hlth & Welf, Unit Publ Hlth Promot, Helsinki, Finland;
178.Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA;
179.Tech Univ Munich, Klin Herz & Kreislauferkrankungen, Deutsch Herzzentrum Munchen, D-80636 Munich, Germany;
180.Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England;
181.Agcy Sci Technol & Res, Genome Inst Singapore, Human Genet, Singapore 138672, Singapore;
182.Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland;
183.Univ Bristol Sch Med, Populat Hlth Sci, Bristol BS8 2BY, Avon, England;
184.Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan;
185.Univ Med Greifswald, Dept Internal Med A, D-17475 Greifswald, Germany;
186.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China;
187.ASTAR, Translat Lab Genet Med, Singapore 138648, Singapore;
188.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore;
189.NIEHS, Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA;
190.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA;
191.Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA;
192.Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Genom Renal Dis & Hypertens Unit, I-20132 Milan, Italy;
193.Helmholtz Zentrum Munchen, Independent Res Grp Clin Epidemiol, D-85764 Neuherberg, Germany;
194.Helmholtz Zentrum Muenchen, Inst Human Genet, D-85764 Neuherberg, Germany;
195.Tech Univ Munich, Inst Human Genet, D-81675 Munich, Germany;
196.DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany;
197.Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia;
198.RIKEN, Lab Genotyping Dev, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan;
199.La Timone Hosp, Lab Haematol, Marseille, France;
200.Aix Marseille Univ, Ctr Cardiovasc & Nutr Res C2VN, INSERM, UMR S 1263, Marseille, France;
201.Univ Autonoma Metropolitana, Dept Econ, Mexico City 09340, DF, Mexico;
202.Univ Western Australia, Med Sch, Perth, WA 6009, Australia;
203.Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA;
204.Univ Aberdeen, Inst Med Sci, Aberdeen Biomed Imaging Ctr, Aberdeen AB25 2ZD, Scotland;
205.Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany;
206.Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England;
207.Oxford Univ Hosp Trust, Oxford NIHR Biomed Res Ctr, Oxford, England;
208.Univ Cambridge, Dept Paediat, Sch Clin Med, Cambridge CB2 0QQ, England;
209.Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland;
210.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA;
211.Imperial Coll London, Int Ctr Circulatory Hlth, London W2 1PG, England;
212.Imperial Coll London, Imperial Clin Trials Unit, London W12 7TA, England;
213.Inst Pasteur, Human Evolutionary Genet Unit, F-75015 Paris, France;
214.Inst Pasteur, Ctr Bioinformat Biostat & Integrat Biol, F-75015 Paris, France;
215.Univ Helsinki, Fac Med, Dept Psychol & Logoped, Helsinki 00014, Finland;
216.Hero Heart Inst, Ludhiana, Punjab, India;
217.Dyanand Med Coll & Hosp, Ludhiana, Punjab, India;
218.Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA;
219.Harvard Med Sch, Boston, MA 02115 USA;
220.Erasmus Univ, Erasmus Sch Econ, Dept Appl Econ, NL-3062 PA Rotterdam, Netherlands;
221.Erasmus Univ, Inst Behav & Biol, NL-3062 PA Rotterdam, Netherlands;
222.IRCCS Neuromed, I-86077 Pozzilli, IS, Italy;
223.Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Div Mol Biol & Biochem, A-8010 Graz, Austria;
224.IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Unit Genom Complex Dis, Barcelona, Spain;
225.San Raffaele Res Inst, Milan, Italy;
226.Natl Inst Hlth & Welf, Dept Publ Hlth Solut, FI-00271 Helsinki, Finland;
227.Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;
228.Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA;
229.Natl Yang Ming Univ, Sch Med, Taipei, Taiwan;
230.KEM Hosp & Res Ctr, Diabet Unit, Pune 411101, Maharashtra, India;
231.Panjab Univ, Chandigarh, India;
232.Univ Vermont, Dept Pathol, Colchester, VT 05446 USA;
233.Uppsala Univ, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Dept Cell & Mol Biol, SE-75237 Uppsala, Sweden;
234.Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, NL-3485 CX Utrecht, Netherlands;
235.Natl Chung Hsing Univ, Inst Med Technol, Taichung, Taiwan;
236.Dayananda Sagar Univ, Sch Basic & Appl Sci, Bangalore 560078, Karnataka, India;
237.Symbiosis Int Univ, Symbiosis Stat Inst, Pune 411007, Maharashtra, India;
238.Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee DD1 9SY, Scotland;
239.Royal Coll Surgeons Ireland, Beaumont Hosp, RCSI Educ Res Ctr, RCSI Mol & Cellular Therapeut MCT, Dublin 9, Ireland;
240.Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland;
241.Curtin Univ, Sch Physiotherapy & Exercise Sci, Fac Hlth Sci, Perth, WA 6102, Australia;
242.Ghent Univ Hosp, Dept Resp Med, B-9000 Ghent, Belgium;
243.Univ Nacl Autonoma Mexico, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Mexico City 04510, DF, Mexico;
244.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City 14080, DF, Mexico;
245.Univ Ioannina, Dept Hyg & Epidemiol, Med Sch, Ioannina 45110, Greece;
246.Res Inst Ind Econ IFN, S-10215 Stockholm, Sweden;
247.Imperial Coll Healthcare NHS Trust, London W12 0HS, England;
248.Natl Inst Hlth & Welf, Helsinki, Finland;
249.Natl Res Council Italy, Inst Genet & Biomed Res Support Unity, Rome, Italy;
250.Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland;
251.Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland;
252.Dayanand Med Coll & Hosp, Hero DMC Heart Inst, Dept Cardiol, Ludhiana 141001, Punjab, India;
253.Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, Beijing 100005, Peoples R China;
254.Univ Edinburgh, Usher Inst Populat Hlth & Informat, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland;
255.KEM Hosp Res Ctr, Diabet Unit, Pune 411011, Maharashtra, India;
256.Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA;
257.Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, NL-3584 CX Utrecht, Netherlands;
258.UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London WC1E 6DD, England;
259.Netherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands;
260.UCL, Farr Inst Hlth Informat Res, London, England;
261.UCL, Inst Hlth Informat, London, England;
262.Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA;
263.Quantinuum Res LLC, San Diego, CA 92101 USA;
264.NYU, Dept Econ, Ctr Expt Social Sci, New York, NY 10003 USA;
265.Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9713GZ Groningen, Netherlands;
266.Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA;
267.Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi 110067, India;
268.Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA;
269.Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Genom, Philadelphia, PA 19104 USA;
270.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA;
271.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore;
272.Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA;
273.Natl Res Council Italy CNR, Inst Biomed Technol Milano, I-20090 Milan, Italy;
274.Bio4Dreams Business Nursery Life Sci, Bio4Dreams SRL, Bio4Dreams Sci Unit, I-20121 Milan, Italy;
275.Christian Albrechts Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany;
276.Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Tukholmankatu 8 B, Helsinki 00014, Finland;
277.Univ Helsinki, Unit Gen Practice, Cent Hosp, Helsinki, Finland;
278.Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48014 USA;
279.Montreal Heart Inst, Montreal, PQ, Canada;
280.Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Ctr Estudios Diabet, Unidad Invest Diabet & Riesgo Cardiovasc, Cuernavaca 01120, Morelos, Mexico;
281.Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA;
282.Ctr Mol Med, Dept Med Solna, Cardiovasc Med Unit, S-17176 Stockholm, Sweden;
283.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore;
284.Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ, Childrens Med Inst, Singapore, Singapore;
285.Univ Oulu, Med Res Ctr Oulu, Res Unit Internal Med, Oulu 90014, Finland;
286.Oulu Univ Hosp, Oulu 90014, Finland;
287.Univ Utah, Sch Med, Dept Internal Med, Div Epidemiol, Salt Lake City, UT 84108 USA;
288.Columbia Univ, Med Ctr, Dept Neurol, Ctr Translat & Computat Neuroimmunol, 650 West 168th St,PH19-311, New York, NY 10032 USA;
289.Broad Inst, Cell Circuits Program, Cambridge, MA 02142 USA;
290.Stockholm Sch Econ, Dept Econ, SE-11383 Stockholm, Sweden;
291.Heidelberg Univ, Dept Ophthalmol, Med Fac Mannheim, D-698167 Mannheim, Germany;
292.Univ Helsinki, Dept Publ Hlth, FI-00014 Helsinki, Finland;
293.Univ Auckland, Dept Stat, Auckland, New Zealand;
294.Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany;
295.Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 9DU, England;
296.Univ Helsinki, Helsinki Coll Adv Studies, Helsinki 00014, Finland;
297.Univ Hosp Schleswig Holstein UKSH, Campus Kiel, D-24105 Kiel, Germany;
298.Univ Kiel, Inst Epidemiol, D-24105 Kiel, Schleswig Holst, Germany;
299.Univ Kiel, PopGen Biobank, D-24105 Kiel, Schleswig Holst, Germany;
300.Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria;
301.King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia;
302.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;
303.Leiden Univ, Dept Publ Hlth Primary Care, Med Ctr, NL-2333 ZA Leiden, Netherlands;
304.Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Kelvin Grove, Qld 4059, Australia;
305.Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, NL-9700 RB Groningen, Netherlands;
306.Columbia Univ, Dept Med, Med Ctr, New York, NY USA;
307.Univ Dundee, Sch Med, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee DD1 9SY, Scotland;
308.Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW, Australia;
309.Univ Western Australia, Div Obstet & Gynaecol, Perth, WA 6009, Australia;
310.Laval Univ, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada;
311.Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada;
312.Natl Res Council Italy, Inst Genet & Biomed Res Support Unity, I-07100 Sassari, Italy;
313.Vrije Univ Amsterdam Med Ctr, Amsterdam Neurosci, Dept Clin Genet, NL-1081 HV Amsterdam, Netherlands;
314.Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98101 USA;
315.Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98101 USA;
316.Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98101 USA;
317.Kaiser Permanente, Washington Hlth Res Inst, Seattle, WA 98101 USA;
318.Univ Montreal, Fac Med, Dept Med, Montreal, PQ H3T 1J4, Canada;
319.Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, NL-3584 CX Utrecht, Netherlands;
320.Oklahoma Ctr Neurosci, Oklahoma City, OK 73104 USA;
321.Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany;
322.DZHK, Munich Heart Alliance, D-80636 Munich, Germany;
323.Regeneron Pharmaceut Inc, Regeneron Genet Ctr, Tarrytown, NY 10591 USA;
324.Univ Bradford, Fac Hlth Studies, Bradford BD7 1DP, W Yorkshire, England;
325.Univ Washington, Div Cardiol, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA;
326.Natl Univ Singapore, Duke NUS Med Sch, Singapore 169857, Singapore;
327.Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany;
328.Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol BS8 2PR, Avon, England;
329.Univ Bristol, Avon Longitudinal Study Parents & Children ALSPAC, Bristol BS8 2PR, Avon, England;
330.Univ Helsinki, Helsinki Univ Hosp, Abdominal Ctr, Endocrinol, Helsinki, Finland;
331.Univ Helsinki, Res Program Diabet & Endocrinol, Helsinki, Finland;
332.Lausanne Univ Hosp, Dept Med, Internal Med, CH-1011 Lausanne, Switzerland;
333.Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19146 USA;
334.Natl Inst Hlth & Welf, Unit Genom & Biomarkers, Helsinki 00271, Finland;
335.Imperial Coll London, Natl Heart & Lung Inst, London W12 0NN, England;
336.Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA;
337.Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland;
338.Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9RG, Midlothian, Scotland;
339.Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA;
340.Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Recommended Citation
GB/T 7714
Wareham, Nicholas J.,Wild, Sarah,Yajnik, Chittaranjan S.,et al. Associations of autozygosity with a broad range of human phenotypes[J]. NATURE COMMUNICATIONS,2019,10.
APA Wareham, Nicholas J..,Wild, Sarah.,Yajnik, Chittaranjan S..,Yuan, Jian-Min.,Zeng, Lingyao.,...&Wang, Ya Xing.(2019).Associations of autozygosity with a broad range of human phenotypes.NATURE COMMUNICATIONS,10.
MLA Wareham, Nicholas J.,et al."Associations of autozygosity with a broad range of human phenotypes".NATURE COMMUNICATIONS 10(2019).
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