IR@PKUHSC  > 北京大学第一临床医学院  > 呼吸和危重症医学科
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, Chaolin1; Wang, Yeming2,5,6; Li, Xingwang7; Ren, Lili8; Zhao, Jianping10; Hu, Yi11; Zhang, Li1; Fan, Guohui2,3,5; Xu, Jiuyang12; Gu, Xiaoying2,3,5
Source PublicationLANCET
Indexed BySCI

Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients.

Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not.

Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49.0 years (IQR 41.0-58.0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8.0 days [IQR 5.0-13.0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNF alpha.

Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Copyright (C) 2020 Elsevier Ltd. All rights reserved.

Subject Area临床医学
WOS HeadingsScience & Technology
Funding OrganizationMinistry of Science and Technology ; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences ; National Science Grant for Distinguished Young Scholars ; National Key Research and Development Program of China ; Beijing Science and Technology Project ; CAMS Innovation Fund for Medical Sciences ; National Mega-projects for Infectious Diseases in China
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS IDWOS:000514576900032
Correspondent ;
Citation statistics
Cited Times:17469[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Jin Yin tan Hosp, Wuhan, Peoples R China;
2.Capital Med Univ, Dept Resp Med, Beijing, Peoples R China;
3.China Japan Friendship Hosp, Ctr Resp Med, Natl Clin Res Ctr Resp Dis, Dept Pulm & Crit Care Med, Beijing, Peoples R China;
4.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China;
5.China Japan Friendship Hosp, Dept Radiol, Beijing, Peoples R China;
6.Chinese Acad Med Sci, Inst Resp Med, Peking Union Med Coll, Beijing, Peoples R China;
7.Capital Med Univ, Beijing Ditan Hosp, Clin & Res Ctr Infect Dis, Beijing, Peoples R China;
8.Chinese Acad Med Sci & Peking Union Med Coll, NHC Key Lab Syst Biol Pathogens & Christophe Meri, Inst Pathogen Biol, Beijing 100730, Peoples R China;
9.Chinese Acad Med Sci & Peking Union Med Coll, Inst Lab Anim Sci, Beijing, Peoples R China;
10.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan, Peoples R China;
Recommended Citation
GB/T 7714
Huang, Chaolin,Wang, Yeming,Li, Xingwang,et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. LANCET,2020,395(10223):497-506.
APA Huang, Chaolin.,Wang, Yeming.,Li, Xingwang.,Ren, Lili.,Zhao, Jianping.,...&Cao, Bin.(2020).Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.LANCET,395(10223),497-506.
MLA Huang, Chaolin,et al."Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China".LANCET 395.10223(2020):497-506.
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