IR@PKUHSC  > 北京大学基础医学院  > 放射医学系
A Cu-64-porphyrin-based dual-modal molecular probe with integrin alpha(v)beta(3) targeting function for tumour imaging
Ai, Lin1; Shi, Jiyun3; Fan, Di1; Wang, Kai1; Gao, Hannan2; Luo, Qi3; Wang, Xin1; Li, Xiaotong1; Tong, Wu1; Zhang, Xin2; Luo, Chuangwei2; Yang, Guangjie2
Source PublicationJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
2020-05-15
ISSN0362-4803
Volume63Issue:5Pages:212-221
Indexed BySCI
AbstractPyropheophorbide-a (Pyro) is a promising multifunctional molecule for multimodal tumour imaging and photodynamic therapy, but its clinical applications are seriously restricted by the limited tumour accumulation capability. Here, we designed and synthesized a small-molecule probe that achieved specific dual-modal tumour imaging based on Pyro. Briefly, a novel molecule combining Pyro, an RGD dimer peptide (3PRGD(2)) and Cu-64, was designed and synthesized, and the obtained molecule, Cu-64-Pyro-3PRGD(2), exhibited high tumour specificity in both positron emission tomography and optical imaging in vivo. c (RGDfk) peptide blocking significantly reduced the efficacy of the probe, which confirmed the integrin alpha(V)beta(3) targeting of this molecular probe. Cu-64-Pyro-3PRGD(2) had very low accumulation in normal organs and could be rapidly cleared through kidney metabolism, which prevented the potential damage to adjacent normal tissues. Overall, combining tumour targeting, dual-modal imaging, and biosafety, Cu-64-Pyro-3PRGD(2) has the potential for clinical use as a molecular imaging probe for tumour diagnosis.
Keywordintegrin alpha(v)beta(3) molecular probe optical imaging PET imaging pyropheophorbide-a
Subject Area基础医学
SubtypeArticle
DOI10.1002/jlcr.3833
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS SubjectBiochemical Research Methods ; Chemistry, Medicinal ; Chemistry, Analytical
WOS KeywordCANCER ; PET ; THERAPY ; PHOTOSENSITIZERS ; NANOPARTICLES ; PEPTIDES
WOS IDWOS:000529933400001
Correspondent Emailailin@bjth.org ; shijiyun@ibp.ac.cn
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/162798
Collection北京大学基础医学院_放射医学系
Affiliation1.Capital Med Univ, Beijing Tiantan Hosp, Dept Nucl Med, Beijing 100070, Peoples R China.;
2.Peking Univ, Med Isotopes Res Ctr, Beijing, Peoples R China.;
3.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China.
Recommended Citation
GB/T 7714
Ai, Lin,Shi, Jiyun,Fan, Di,et al. A Cu-64-porphyrin-based dual-modal molecular probe with integrin alpha(v)beta(3) targeting function for tumour imaging[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,2020,63(5):212-221.
APA Ai, Lin.,Shi, Jiyun.,Fan, Di.,Wang, Kai.,Gao, Hannan.,...&Yang, Guangjie.(2020).A Cu-64-porphyrin-based dual-modal molecular probe with integrin alpha(v)beta(3) targeting function for tumour imaging.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,63(5),212-221.
MLA Ai, Lin,et al."A Cu-64-porphyrin-based dual-modal molecular probe with integrin alpha(v)beta(3) targeting function for tumour imaging".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 63.5(2020):212-221.
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