IR@PKUHSC  > 北京大学基础医学院  > 放射医学系
In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy
Hou, Rui1,2; Liang, Xiaolong3; Li, Xiaoda1,2; Zhang, Xu1,2; Ma, Xiaotu4; Wang, Fan1,2,4
Source PublicationBIOMATERIALS SCIENCE
2020-05-07
ISSN2047-4830
Volume8Issue:9Pages:2526-2536
Indexed BySCI
AbstractSonodynamic therapy (SDT) is a prospective therapy for many tumors by activation of sonosensitizers to produce reactive oxygen species (ROS) by ultrasound (US). However, limited generation of ROS and low drug delivery efficiency of sonosensitizers to the tumor tissue still hinder the application of SDT. Herein, an amphiphilic rose bengal (ARB) conjugate was designed to fabricate rose bengal microbubbles (RB-MBs) with high drug-loading contents (similar to 6.8%) and excellent contrast enhancement capability for US imaging, well suited for detecting tumor location and size. More importantly, RB-MBs could be successfully converted into RB-NPs by local US exposure, resulting in similar to 7.5 times higher drug accumulation at the tumor tissue through the sonoporation effect as compared to RB-NPs and RB-MBs without US sonication. Meanwhile, using RB as the MB shell facilitated US energy transfer by the US mediated collapse of MBs through either a sonoluminescence or pyrolysis process; thus, the ROS generation efficiency could be greatly enhanced, resulting in a significantly higher tumor inhibition rate for the RB-MBs + US (similar to 76.5%) in the HT-29 tumor model as compared to conventional MBs + US and RB-NPs + US (similar to 23.8% and similar to 49.2%), respectively. All these results suggested that this novel sonosensitizer delivery system of RB-MBs combined with US is a powerful strategy for remarkably enhancing SDT therapeutic efficacy with minimal side effects, showing great potential in cancer theranostics.
Subject Area基础医学
SubtypeArticle
DOI10.1039/c9bm02046b
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS KeywordDRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; LOADED MICROBUBBLES ; PROTOPORPHYRINIX ; CANCER ; GENE ; PORPHYRIN ; OXYGEN ; APOPTOSIS ; CELLS
WOS IDWOS:000532529400013
Correspondent Emailxiaolong_liang@bjmu.edu.cn ; wangfan@bjmu.edu.cn
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/162808
Collection北京大学基础医学院_放射医学系
北京大学基础医学院
北京大学护理学院_护理学院
北京大学第三临床医学院_超声影像科
Affiliation1.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing, Peoples R China.;
2.Peking Univ, Dept Radiat Med, Sch Basic Med Sci, Beijing, Peoples R China.;
3.Peking Univ, Dept Ultrasound, Hosp 3, Beijing, Peoples R China.;
4.Peking Univ, Med Isotopes Res Ctr, Sch Basic Med Sci, Beijing, Peoples R China.
First Author AffilicationPeking University School of Basic Medical Sciences
Recommended Citation
GB/T 7714
Hou, Rui,Liang, Xiaolong,Li, Xiaoda,et al. In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy[J]. BIOMATERIALS SCIENCE,2020,8(9):2526-2536.
APA Hou, Rui,Liang, Xiaolong,Li, Xiaoda,Zhang, Xu,Ma, Xiaotu,&Wang, Fan.(2020).In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy.BIOMATERIALS SCIENCE,8(9),2526-2536.
MLA Hou, Rui,et al."In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy".BIOMATERIALS SCIENCE 8.9(2020):2526-2536.
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