IR@PKUHSC  > 北京大学第二临床医学院
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
Wang, Yeming1,3; Zhang, Dingyu4; Du, Guanhua5,6; Du, Ronghui7; Zhao, Jianping8; Jin, Yang9; Fu, Shouzhi10; Gao, Ling11; Cheng, Zhenshun12; Lu, Qiaofa13; Hu, Yi14; Luo, Guangwei15; Wang, Ke5,6; Lu, Yang5,6; Li, Huadong4; Wang, Shuzhen4; Ruan, Shunan4; Yang, Chengqing7; Mei, Chunlin7; Wang, Yi8; Ding, Dan8; Wu, Feng9; Tang, Xin9; Ye, Xianzhi10; Ye, Yingchun11; Liu, Bing12; Yang, Jie13; Yin, Wen14; Wang, Aili15; Fan, Guohui2; Zhou, Fei1; Liu, Zhibo1; Gu, Xiaoying2; Xu, Jiuyang16; Shang, Lianhan1,17; Zhang, Yi1; Cao, Lianjun18; Guo, Tingting18; Wan, Yan18; Qin, Hong19; Jiang, Yushen20; Jaki, Thomas21,22; Hayden, Frederick G.23; Horby, Peter W.24; Cao, Bin1,3,25,26; Wang, Chen1,6,25,26
Source PublicationLANCET
2020-05-16
ISSN0140-6736
Volume395Issue:10236Pages:1569-1578
Indexed BySCI
AbstractBackground No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models.
Subject Area临床医学
SubtypeArticle
DOI10.1016/S0140-6736(20)31022-9
Language英语
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS KeywordEBOLA-VIRUS ; GS-5734
WOS IDWOS:000536542900023
Citation statistics
Cited Times:932[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/163130
Collection北京大学第二临床医学院
Affiliation1.Peking Union Med Coll, Beijing 100730, Peoples R China.;
2.Wuhan Lung Hosp, Wuhan, Peoples R China.;
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan, Peoples R China.;
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan, Peoples R China.;
5.Wuhan Third Hosp, Wuhan, Peoples R China.;
6.Wuhan Univ, Renmin Hosp, Wuhan, Peoples R China.;
7.Wuhan Univ, Zhongnan Hosp, Wuhan, Peoples R China.;
8.Wuhan Fourth Hosp, Wuhan, Peoples R China.;
9.Cent Hosp Wuhan, Wuhan, Peoples R China.;
10.Wuhan First Hosp, Wuhan, Peoples R China.;
11.Tsinghua Univ, Sch Med, Beijing, Peoples R China.;
12.Beijing Univ Chinese Med, Beijing, Peoples R China.;
13.Tigermed Consulting, Hangzhou, Peoples R China.;
14.Teddy Clin Res Lab, Shanghai, Peoples R China.;
15.Hangzhou DIAN Med Lab, Hangzhou, Peoples R China.;
16.Univ Lancaster, Lancaster, England.;
17.Univ Cambridge, Cambridge, England.;
18.Univ Virginia, Sch Med, Charlottesville, VA 22908 USA.;
19.Univ Oxford, Int Severe Acute Resp & Emerging Infect Consortiu, Oxford, England.;
20.Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China.;
21.China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Ctr Resp Med, Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China.;
22.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China.;
23.Capital Med Univ, Dept Resp Med, Beijing, Peoples R China.;
24.JinYin Tan Hosp, Wuhan, Hubei, Peoples R China.;
25.Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China.;
26.Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijiing, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Yeming,Zhang, Dingyu,Du, Guanhua,et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial[J]. LANCET,2020,395(10236):1569-1578.
APA Wang, Yeming.,Zhang, Dingyu.,Du, Guanhua.,Du, Ronghui.,Zhao, Jianping.,...&Wang, Chen.(2020).Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.LANCET,395(10236),1569-1578.
MLA Wang, Yeming,et al."Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial".LANCET 395.10236(2020):1569-1578.
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