IR@PKUHSC  > 北京大学第一临床医学院  > 小儿外科
其他题名Surgical treatment for huge hepatoblastoma in children
贾钧; 黄柳明; 张宏武; 温泉; 刘钢
关键词肝肿瘤 肝切除术 抗肿瘤联合化疗方案 Liver Neoplasms Hepatectomy Antineoplastic Combined Chemotherapy Protocol
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 对小儿巨大肝母细胞瘤不阻断保留肝血流巨大肝母细胞瘤切除的方法进行探讨.方法 回顾性分析2001年7月至2009年1月北京大学第一医院12例巨大肝母细胞瘤病例,年龄11个月~12岁,平均年龄3.2岁.肿瘤直径10~23 cm.术前常规化疗3~7个疗程,肿瘤缩小至能进行根治术时,全部采用规则的肝叶(段)切除技术,施行不阻断预保留肝血流巨大肝母细胞瘤切除术.结果 本组12例全部成功完成手术,其中肝右三叶(Ⅳ、Ⅴ~Ⅷ)切除5例,右半肝(Ⅴ~Ⅷ)切除4例,第二肝门肝段(Ⅳ、Ⅶ、Ⅷ)切除1例,右下叶肝段(Ⅴ、Ⅵ)切除1例,左半肝(Ⅱ、Ⅲ、Ⅳ)切除1例.术中血流动力学指标稳定,无围手术期死亡.术后常规化疗.随访2个月~7年8个月,无瘤生存11例,其中5年以上者6例;另1例在术后5个月发生脑、肺转移,于术后7个月死亡.结论 对巨大肝母细胞瘤术前化疗可使肿瘤缩小,使原来无法手术切除的肿瘤变得可以切除.不阻断预保留肝血流巨大肝母细胞瘤切除术是一种安全可行的手术方法. Objective To discuss the surgical treatment for huge hepatoblastoma in children,and the technique of hepatectomy without blockade of the blood supply to the remained liver lobes.Methods We reviewed 12 cases of huge hepatoblastorna who had been operated from July 2001 to January 2009 in our hospital.The mean age of the children was 3.2 years(range,11 months to 12 years).The diameter of the tumor was from 10 to 23 cm.3~7 cycles of chemotherapy was routinely administrated before operation.When the tumor reduced to a certain size that radical resection could be performed safely,regular hepatectomy was conducted.Hepatoblastoma resection without blocking the blood supply to the remained liver lobes was performed in every patient.Results The operations were successfully accomplished in all the 12 children.5 cases received right trihepatectomy (segment Ⅳ,Ⅴ~Ⅷ),4 cases received right hemihepatectomy(segment Ⅴ~Ⅷ),and the other 3 cases received Ⅳ,Ⅶ,Ⅷ segmentectomy,right Ⅴ,Ⅵ segmentectomy,and left hemihepatectomy respectively.The intraoperative hemodynamic parameters were stable,and there was no perioperative mortality.Postoperative chemotherapy wag routinely administrated.The follow-up period varied from 2 to 92 months.11 children survived and were disease free,among those 6 children have survived for more than 5 years.One child had brain and lung metastasis 5 months post operation,and died 7 months post operation. Conclusion Preoperative chemotherapy administrated to children with huge hepatoblastoma can reduce the tumor size and render tumor reseetable.Hepatoblastoma resection without blocking the blood supply to the remained liver lobes is a safe and feasible surgical technique.
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贾钧,黄柳明,张宏武,等. 小儿巨大肝母细胞瘤的外科治疗[J]. 中华普通外科杂志,2009,24(12):981-983.
APA 贾钧,黄柳明,张宏武,温泉,&刘钢.(2009).小儿巨大肝母细胞瘤的外科治疗.中华普通外科杂志,24(12),981-983.
MLA 贾钧,et al."小儿巨大肝母细胞瘤的外科治疗".中华普通外科杂志 24.12(2009):981-983.
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