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IR@PKUHSC  > 北京大学第一临床医学院  > 神经内科  > 期刊论文
学科主题: 神经病学
题名:
遗传因素和铁蛋白水平与不宁腿综合征发病年龄的关系
其他题名: Effect of hereditary factor and ferritin on age of restless legs syndrome onset
作者: 郭小明; 陈静; 黄一宁; 孙相如
关键词: 不宁腿综合征 ; 家族史 ; 铁蛋白 ; 发病年龄 ; Restless legs syndrome ; Family history ; Ferritin ; Age of onset
刊名: 中风与神经疾病杂志
发表日期: 2010
卷: 27, 期:1, 页:57-59
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨家族遗传因素和血清铁蛋白水平与早发不宁腿综合征和晚发不宁腿综合征的关系.方法 对35例原发性不宁腿综合征病例按照国际惯例分为早发不宁腿综合征组(21例)和晚发不宁腿综合征组(14例),分别统计家族史有无及血清铁蛋白水平,并进行统计学分析.结果 早发不宁腿综合征组家族史阳性率(57.1%)高于晚发不宁腿综合征组(14.3%),而晚发不宁腿综合征组血清铁蛋白水平(67.66±28.14ng/m1)较早发不宁腿综合征组(104.52±54.0ng/ml)低,差异均有统计学意义(P<0.05).结论 遗传因素对早发不宁腿综合征的影响大于晚发不宁腿综合征,而血清铁蛋白的降低对晚发不宁腿综合征的影响大于早发不宁腿综合征. Objective To investigate the correlation between the onset age of restless legs syndrome (RLS) with the hereditary factor and the level of serum ferritin. Method Thirty-five primary restless legs syndrome patients were divided into early-onset RLS group (21 cases) and late-onset RLS group (14 cases) according to the international standard. The family history and serum ferritin level were recorded. The data were statistically analyzed with SPSS software. Result Rate of positive family history was higher in the early-onset RLS group(57.1%)than in the late-onset RLS group(14.3%) ,but the level of serum ferritin was lower in the late-onset RLS group(67.66 ±28.14ng/ml)than in the early-onset RLS group (104.52 ± 54.02ng/ml),which were significantly different(P < 0.05). Conclusion Hereditary factor has more effect on early-onset RLS than on late-onset RLS,but decrease of serum ferritin level has more effect on late-onset RLS than on earlyonset RLS.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/40979
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 北京大学第一医院神经内科,北京,100034
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