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学科主题神经病学
他汀类药物相关肌病的临床和骨骼肌病理特点
其他题名The clinical and muscular pathological features of statin-induced myopathy
孟令超; 鹿媛媛; 张巍; 王朝霞; 吕鹤; 袁云
关键词肌疾病 他汀类药物 骨骼肌病理 免疫性坏死性肌肉病 Muscular Diseases Statins Muscle Pathology Autoimmune Necrotizing Myopathy
刊名中华内科杂志
2015
DOI10.3760/cma.j.issn.0578-1426.2015.08.014
54期:8页:716-720
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨他汀类药物相关肌病(简称他汀肌病)的临床特点及骨骼肌病理改变特点.方法 分析2012年4月至2014年10月就诊于北京大学第一医院并行肌肉活检的9例他汀肌病患者的临床及病理资料.结果 9例患者均口服他汀类药物4d至4年,就诊年龄55 ~74(63 ±6)岁,其中男6例,女3例.3例出现肌痛,6例出现四肢近端为主的肌无力,3例无任何临床症状.所有患者血清肌酸激酶(CK)升高(468 ~8 000 U/L).7例患者行血清肌炎抗体检查,均阴性.6例患者行肌电图检查,2例出现肌源性损害.6例患者行双侧大腿骨骼肌MRI检查,其中2例显示有部分肌群水肿及轻度脂肪化.骨骼肌活检病理主要表现:肌纤维萎缩、坏死、再生、脂肪滴增多,部分患者出现破碎蓝纤维、细胞色素c氧化酶阴性肌纤维及还原型辅酶Ⅰ四氮唑还原酶活性降低,主要组织相容性复合物-Ⅰ在肌纤维膜不同程度表达,补体C5b-9染色显示肌内衣、胞质以及毛细血管少量补体沉积.随访发现,多数(7例)患者停用他汀类药物或换用其他他汀类药物后,症状及CK水平改善,仅2例患者需应用免疫抑制治疗且有效.结论 本组患者中多数(7例)他汀肌病为自限性,停用他汀类药物后可自行好转,个别患者(2例)可出现免疫性坏死性肌肉病,需要应用免疫抑制治疗. Objective To explore clinical and muscular pathological features of statin-induced myopathy.Methods Nine patients were enrolled in this study,who were diagnosed as statin-induced myopathy by muscle biopsy in Peking University First Hospital from April,2012 to October,2014.The clinical data and pathological findings were analyzed.Results The exposure time to statins varied from 4 days to 4 years in the total of 9 patients,6 males and 3 females,with the average age of 63 ± 6 (55 to 74) years old.Three patients suffered from myalgia and 6 patients complained of weakness mainly at the proximal limbs,while no symptoms occured in 3 patients.Serum creatine kinase (CK) increased in all patients with the maximum value varied from 468 to 8 000 U/L.Serum myositis antibodies were tested in 7 patients and all were negative.Electromyogram was performed in six patients with myogenic damage found in 2 patients.MRI of bilateral thigh muscle was carried out in six patients with muscle edema and mild fatty infiltration found in 2 patients.All patients underwent skeletal muscle biopsy with histochemical and immunohistochemical staining.The main muscular pathological features were muscle fiber atrophy,necrosis,regeneration and increased lipid droplets.Ragged blue fiber,cytochrome C oxidase-negative muscle fibers and decreased NADH activity were observed in some patients.MHC-Ⅰ expressed in the sarcolemma of muscle fibers at various levels.Mild C5b-9 staining was found in the endomysium,capillary and cytoplasm.Symptoms and the level of CK were improved in 7 patients after discontinuing statins or changing to another statin,while the immunosuppressive therapy were used in 2 patients and shown to be effective.Conclusions Statin induced myopathy is self-limiting in most patients,with improvement after discontinuation of statins.Few patients with autoimmune necrotic myopathy need immunosuppressive therapy.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/41169
专题北京大学第一临床医学院_神经内科
作者单位100034,北京大学第一医院神经内科
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孟令超,鹿媛媛,张巍,等. 他汀类药物相关肌病的临床和骨骼肌病理特点[J]. 中华内科杂志,2015,54(8):716-720.
APA 孟令超,鹿媛媛,张巍,王朝霞,吕鹤,&袁云.(2015).他汀类药物相关肌病的临床和骨骼肌病理特点.中华内科杂志,54(8),716-720.
MLA 孟令超,et al."他汀类药物相关肌病的临床和骨骼肌病理特点".中华内科杂志 54.8(2015):716-720.
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