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一氧化氮合酶及血红素氧化酶在颈动脉粥样硬化斑块中的表达
其他题名Expression of nitric oxide synthase and heme oxygenase in carotid atherosclerotic plaque
张家涌1; 段鸿洲1; 鲍圣德1; 袁云1; 黄一宁1
关键词内皮型一氧化氮合酶 诱导型一氧化氮合酶 血红素氧化酶-1 免疫组织化学 动脉粥样硬化 Endothelial Nitric Oxide Synthase Inducible Nitric Oxide Synthase Heme Oxygenase-1 Immunohistochemistry Atherosclerosis
刊名中华神经外科杂志
2008
DOI10.3321/j.issn:1001-2346.2008.11.023
24期:11页:868-871
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨内皮型一氧化氮合酶(eNOS)、诱导型一氧化氮合酶(iNOS)和血红素氧化酶-1(HO-1)在动脉粥样硬化过程中表达的变化及相互关系.方法 选取10例经颈动脉内膜剥脱术取下的粥样硬化斑块标本,以10例正常颈内动脉为对照,用免疫组化方法检测eNOS、iNOS及HO-1在两组颈动脉内的表达,应用统计学的方法对结果进行分析.结果 (1)eNOS在粥样硬化斑块中表达较正常颈动脉表达明显减弱(P<0.001);(2)iNOS在正常颈动脉中没有表达,但在粥样硬化斑块中的平滑肌细胞以及泡沫细胞中有明显表达;(3)HO-1仅在正常颈动脉内皮细胞中表达,而在粥样硬化斑块中,HO-1不仅在内皮细胞中表达,而且在平滑肌细胞以及泡沫细胞中也有较高表达,与正常组相比其表达明显增高(P<0.001);(4)统计分析显示:eNOS阳性表达与iNOS阳性表达呈负相关(r=-0.680,P<0.001),iNOS阳性表达与HO-1阳性表达呈正相关(r=0.898,P<0.001),eNOS阳性表达与HO-1阳性表达呈负相关(r=-0.713,P<0.001).结论 随着动脉粥样硬化的形成,eNOS产生减少而iNOS和HO-1产生增多,一氧化氮合酶及血红素氧化酶在动脉粥样硬化中显示互补及代偿性调节的作用. Objective To investigate the change rule and correlation of endothelial nitric oxide synthase(eNOS), inducible nitric oxide synthase(iNOS) and berne oxygenase-1 (HO-1)in atherosclerosis. Method The expressions of eNOS, iNOS and HO-1 were detected by immunohistochemistry in 10 carotid atherosclerotic plaques which were acquired by carotid endarterectomy and 10 normal internal carotid arteries. The results were analyzed with statistic methods. Results (1) eNOS expresses in endothelium cells in normal carotid artery, while the expression decreases significantly in carotid atherosclerotic plaque(P <0.001). (2) iNOS shows negative expression in normal carotid artery. But in atherosclerotic plaque, iNOS expresses strongly in both smooth muscle cells and foam cells(P<0.001). (3) HO-1 only expresses in endothelium cells in normal carotid artery, but in atherosclerotic plaque, HO-1 expresses not only in endothelium cells but also in smooth muscle cells and foam cells (P<0.001). (4) The statistic analysis shows: The expression of eNOS and iNOS had negative correlation (r=-0.680, P<0.001) ; the expression of eNOS and HO-1 also had negative correlation(r=-0.713 ,P<0.001) ; the expression of iNOS and HO-1 had positive correlation (r=0.898, P<0.001). Conclusion During the process of atberosclerosis, eNOS decreases while iNOS and HO-1 increase. The reciprocal relationship between HO and NOS in atherosclerosis could play the inhibitory role against atherosclerotic lesion.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/41619
Collection北京大学第一临床医学院_神经外科
作者单位1.北京大学第一医院神经外科,100034
2.北京大学第一医院神经内科,100034
Recommended Citation
GB/T 7714
张家涌,段鸿洲,鲍圣德,等. 一氧化氮合酶及血红素氧化酶在颈动脉粥样硬化斑块中的表达[J]. 中华神经外科杂志,2008,24(11):868-871.
APA 张家涌,段鸿洲,鲍圣德,袁云,&黄一宁.(2008).一氧化氮合酶及血红素氧化酶在颈动脉粥样硬化斑块中的表达.中华神经外科杂志,24(11),868-871.
MLA 张家涌,et al."一氧化氮合酶及血红素氧化酶在颈动脉粥样硬化斑块中的表达".中华神经外科杂志 24.11(2008):868-871.
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