北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 神经外科  > 期刊论文
学科主题: 神经病学
题名:
一氧化氮合酶及血红素氧化酶在颈动脉粥样硬化斑块中的表达
其他题名: Expression of nitric oxide synthase and heme oxygenase in carotid atherosclerotic plaque
作者: 张家涌1; 段鸿洲1; 鲍圣德1; 袁云1; 黄一宁1
关键词: 内皮型一氧化氮合酶 ; 诱导型一氧化氮合酶 ; 血红素氧化酶-1 ; 免疫组织化学 ; 动脉粥样硬化 ; Endothelial Nitric Oxide Synthase ; Inducible Nitric Oxide Synthase ; Heme oxygenase-1 ; Immunohistochemistry ; Atherosclerosis
刊名: 中华神经外科杂志
发表日期: 2008
DOI: 10.3321/j.issn:1001-2346.2008.11.023
卷: 24, 期:11, 页:868-871
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨内皮型一氧化氮合酶(eNOS)、诱导型一氧化氮合酶(iNOS)和血红素氧化酶-1(HO-1)在动脉粥样硬化过程中表达的变化及相互关系.方法 选取10例经颈动脉内膜剥脱术取下的粥样硬化斑块标本,以10例正常颈内动脉为对照,用免疫组化方法检测eNOS、iNOS及HO-1在两组颈动脉内的表达,应用统计学的方法对结果进行分析.结果 (1)eNOS在粥样硬化斑块中表达较正常颈动脉表达明显减弱(P<0.001);(2)iNOS在正常颈动脉中没有表达,但在粥样硬化斑块中的平滑肌细胞以及泡沫细胞中有明显表达;(3)HO-1仅在正常颈动脉内皮细胞中表达,而在粥样硬化斑块中,HO-1不仅在内皮细胞中表达,而且在平滑肌细胞以及泡沫细胞中也有较高表达,与正常组相比其表达明显增高(P<0.001);(4)统计分析显示:eNOS阳性表达与iNOS阳性表达呈负相关(r=-0.680,P<0.001),iNOS阳性表达与HO-1阳性表达呈正相关(r=0.898,P<0.001),eNOS阳性表达与HO-1阳性表达呈负相关(r=-0.713,P<0.001).结论 随着动脉粥样硬化的形成,eNOS产生减少而iNOS和HO-1产生增多,一氧化氮合酶及血红素氧化酶在动脉粥样硬化中显示互补及代偿性调节的作用. Objective To investigate the change rule and correlation of endothelial nitric oxide synthase(eNOS), inducible nitric oxide synthase(iNOS) and berne oxygenase-1 (HO-1)in atherosclerosis. Method The expressions of eNOS, iNOS and HO-1 were detected by immunohistochemistry in 10 carotid atherosclerotic plaques which were acquired by carotid endarterectomy and 10 normal internal carotid arteries. The results were analyzed with statistic methods. Results (1) eNOS expresses in endothelium cells in normal carotid artery, while the expression decreases significantly in carotid atherosclerotic plaque(P <0.001). (2) iNOS shows negative expression in normal carotid artery. But in atherosclerotic plaque, iNOS expresses strongly in both smooth muscle cells and foam cells(P<0.001). (3) HO-1 only expresses in endothelium cells in normal carotid artery, but in atherosclerotic plaque, HO-1 expresses not only in endothelium cells but also in smooth muscle cells and foam cells (P<0.001). (4) The statistic analysis shows: The expression of eNOS and iNOS had negative correlation (r=-0.680, P<0.001) ; the expression of eNOS and HO-1 also had negative correlation(r=-0.713 ,P<0.001) ; the expression of iNOS and HO-1 had positive correlation (r=0.898, P<0.001). Conclusion During the process of atberosclerosis, eNOS decreases while iNOS and HO-1 increase. The reciprocal relationship between HO and NOS in atherosclerosis could play the inhibitory role against atherosclerotic lesion.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/41619
Appears in Collections:北京大学第一临床医学院_神经外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.北京大学第一医院神经外科,100034
2.北京大学第一医院神经内科,100034
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[张家涌]'s Articles
[段鸿洲]'s Articles
[鲍圣德]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[张家涌]‘s Articles
[段鸿洲]‘s Articles
[鲍圣德]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace