To investigate the trends antibiobic resistance in strains of shigella isolated in Beijing,the susceptibility of30 antimicrobial agents wes observed in 327 Shigella strans isolated from to 2001. The resiance rates of fluoroquinoloes increased gradually over the eight years, and the resistance rates of norfloxacin and ciprofloxacin (11.6% and 16.3% respec tiveiy) during 1997-1998 were significantly higher than that in 1994 (P＜0.001). Meanwhile intemedtrely susceptible stiains of fluoroquinolones also incrased gradually from 1994 to 1998, and increased rapidly during 1999-2001, which sug gests that the resistance rate of fluoroquinolones may increase in the coming years. In addition there wes partial cross resistance among fluoroquinolones, and the rate of resistance to 5 species of fluoroquinolones had been increasing from 2001 anl.It increased to 8.5% during 1999-2001. The resistance rates of Aminoglycoside and the first-generation cephalosporins remained relatively stable over the eight years, can be usesd as the first-line agents for the treatment of dysentery, but in termediately susceptible strains of amikacin and almost all of cephalosporins have increased,which should be noticed.