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EBV 搞体与 EBV DNA 水平的影响因素及其相关性分析
其他题名A study of the relationship between EBV DNA and EBV antibody levels
陆海英1; 魏秀琴1; 徐小元1; 于岩岩1; 吴赤红1; 刘丹1
关键词爱泼斯坦巴尔病毒感染 Ebv Dna Epstein -barr Virus Infections Ebv Dna
刊名临床肝胆病杂志
2015
DOI10.3969/j.issn.1001-5256.2015.05.032
5页:766-770
收录类别中国科技核心期刊
文章类型Journal Article
摘要目的:分析 EB 病毒(EBV)抗体及 EBV DNA 的影响因素及关联性。方法回顾性分析2014年1-9月在北京大学第一医院就诊的143例患者的年龄、性别、血常规、肝功能、EBV 抗体及 DNA 检查结果,用 Spearman 相关性分析对 EBV 抗体及 EBV DNA 的相关影响因素进行分析,多个独立样本间比较使用 Kruskal -Wallis H 检验,独立样本间两两比较使用 Mann -Whitney U 检验。结果血清 EBV DNA(r =0.169~0.693,P <0.05)、EBV -VCA -IgM(r =0.153~0.434,P <0.05)均与外周血淋巴细胞 EBV DNA 、ALT、AST、ALP、GGT、白细胞(WBC)及异形淋巴细胞呈正相关,并且两者也呈正相关(r =0.434,P =0.00);外周血淋巴细胞 EBV DNA 与血清EBV DNA、EBV -VCA -IgM、AST、ALP、WBC 及异形淋巴细胞呈正相关(r =0.207~0.693,P <0.05)。外周血淋巴细胞 EBV DNA 阳性率70.6%(101/143),血清 EBV DNA 阳性率32.2%(46/143)。EBV -VCA -IgM阳性率22.4%(32/143),22.5%(25/111)的 EBV-VCA -IgM阴性患者血清 EBV DNA 阳性。血清 EBV DNA 阳性患者 EBV -VCA -IgM阳性率(21/46,45.7%)明显高于外周血淋巴细胞 EBV DNA 阳性者(29/101,28.7%),差异有统计学意义(χ2=7.95,P <0.01)。结论血清 EBV DNA 和 EBV -VCA -IgM有较强的关联性,并且前者的阳性率高于后者,更有助于 EBV 感染的早期诊断,联合检测两项指标可提高 EBV 现症感染的检出率。 Objective To study the relationship between Epstein -Barr virus (EBV)DNA and EBV antibody levels.Methods A retrospec-tive study was conducted on 143 patients who underwent EBV DNA testing in serum and lymphocytes from January to August,2014.The clini-cal data,including age,sex,blood routine and biochemical examination,serum/lymphocyte EBV DNA,EBV -VCA -IgM,and EBV -VCA -IgG were recorded.Spearman correlation analysis was used to measure the degree of the relationships.Kruskal -Wallis H test or Mann -Whitney U test were applied to compare the differences between three or two groups.Results The spearman rank correlation coeffi-cient between serum EBV DNA and EBV -VCA -IgMlevels was 0.434 (P =0.00),while the correlation coefficients of serum EBV DNA level and EBV -VCA -IgMlevel with lymphocyte EBV DNA,alanine aminotransferase (ALT),aspartate aminotransferase (AST),alka-line phosphatase (ALP),gamma -glutamyl transpeptidase (GGT),white blood cells (WBC),and heterotypic lymphocytes ranged from 0.169 to 0.693 (P <0.05)and from 0.153 to 0.434 (P <0.05),respectively.The spearman rank correlation coefficient of lymphocyte EBV DNA with serum EBV DNA,EBV -VCA -IgM,AST,ALP,WBC,and heterotypic lymphocytes ranged from 0.207 to 0.693 (P <0.05).The positive rates of EBV DNA in lymphocytes and serum were 70.6% (101 /143)and 32.2% (46/143),respectively.The EBV -VCA-IgMpositive rate was 22.4% (32 /143),and 22.5% (25 /111)of the patients with negative EBV -VCA -IgMwere positive for serum EBV DNA.The overall positive rate for EBV -VCA -IgG was 91.6% (131 /143).The EBV -VCA -IgM positive rate in patients with positive serum EBV DNA (21 /46,45.7%)was significantly higher than that in patients with positive lymphocyte EBV DNA (29 /101, 28.7%)(χ2 =7.95,P <0.01).Conclusion Serum EBV DNA level is strongly correlated with EBV -VCA -IgMlevel.Moreover,ser-um EBV DNA exhibits a higher positive rate than EBV -VCA -IgM.Simultaneous detection of serum EBV DNA and EBV -VCA -IgM may benefit the diagnosis of current EBV infection.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/41736
Collection北京大学第一临床医学院_感染疾病科
作者单位1.北京大学第一医院 感染疾病科,北京,100034
2.武威市人民医院,甘肃 武威,733300
Recommended Citation
GB/T 7714
陆海英,魏秀琴,徐小元,等. EBV 搞体与 EBV DNA 水平的影响因素及其相关性分析[J]. 临床肝胆病杂志,2015(5):766-770.
APA 陆海英,魏秀琴,徐小元,于岩岩,吴赤红,&刘丹.(2015).EBV 搞体与 EBV DNA 水平的影响因素及其相关性分析.临床肝胆病杂志(5),766-770.
MLA 陆海英,et al."EBV 搞体与 EBV DNA 水平的影响因素及其相关性分析".临床肝胆病杂志 .5(2015):766-770.
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