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学科主题: 感染疾病科
题名:
HBeAg阴性与阳性慢性乙型肝炎患者临床分析
其他题名: Analysis of clinical characteristics between HBeAg-negative and HBeAg-positive patients with chronic hepatitis B
作者: 席宏丽; 李敏然; 鲍毅; 徐小元
关键词: 肝炎,乙型,慢性 ; 肝炎e抗原,乙型 ; DNA ; Hepatitis B,chronic ; Hepotitis B e antigens ; DNA
刊名: 中华实验和临床病毒学杂志
发表日期: 2013
DOI: 10.3760/cma.j.issn.1003-9279.2013.06.025
卷: 27, 期:6, 页:472-473
收录类别: 中国科技核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 观察乙肝病毒e抗原(HBeAg)阴性与阳性慢性乙型肝炎患者在年龄、ALT、乙肝病毒脱氧核糖核酸(HBV DNA)定量方面的特点.方法 回顾性分析125例慢性乙型肝炎患者的临床资料,根据HBeAg表达情况分为HBeAg阴性与阳性慢性乙型肝炎两组,对两组患者的年龄、ALT和HBV DNA进行统计学分析.结果 125例慢性乙型肝炎患者中,HBeAg阴性组24例,占19.2%;HBeAg阳性组101例,占80.8%.两组在平均年龄、HBV DNA之间比较,差异具有统计学意义;ALT之间比较没有统计学意义.在HBeAg阴性组中,HBV DNA定量较低,随着病毒载量的增高,ALT异常的数量呈下降趋势;在HBeAg阳性组中,HBV DNA定量较高,随着病毒载量的增高,ALT异常的数量大致呈上升趋势.结论 HBeAg阴性慢性乙型肝炎患者年龄较HBeAg阳性患者高,ALT、HBVDNA定量水平低于HBeAg阳性者.随着病毒载量的增高,ALT异常的数量呈下降趋势,而后者则相反. Objective To observe the characteristics of age,alanine aminotransferase (ALT) and hepatitis B virus DNA (HBV DNA) quantitative between HBeAg-negative and HBeAg-positive patients with chronic hepatitis B.Methods The clinical datas of 125 patients with chronic hepatitis B were analyzed retrospectively.According to the expression of HBeAg,divided the chronic hepatitis B patients into two groups:HBeAg-negative and-positive.The datas of age,ALT and HBV DNA were analyzed by statistical methods.Results Among 125 patients,24 cases were HBeAg-negative group accounting for 19.2% ; 101 cases were HBeAg-positive group accounting for 80.8%.The difference between two groups in average age and HBV DNA was significant,the comparison between ALT of two groups has no statistical significance.In HBeAg-negative groups,HBV DNA quantitative is lower,as the viral load increase,the number of abnormal ALT show a downward trend; In HBeAg positive group,HBV DNA quantitative is higher,as the viral load increase,the ALT abnormal quantity generally show a upward trend.Conclusions The age of HBeAgnegative chronic hepatitis B patients is larger than the HBeAg-positive patients,the level of ALT,HBV DNA quantitative in HBeAg-negative chronic hepatitis B patients lower than the HBeAg-positive patients,and as the viral load increase,the ALT abnormal number is on the decline,while the latter is opposite.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/41854
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 100034,北京大学第一医院感染性疾病科
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