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IR@PKUHSC  > 北京大学第一临床医学院  > 中医中西医结合科  > 期刊论文
学科主题: 中西医结合
题名:
淫羊藿苷神经保护作用机制研究进展
其他题名: Adances in neuroprotective effects mechanisms of Icariin
作者: 宋宜祥; 黎巍威; 王学美
关键词: 淫羊藿苷 ; 神经保护作用 ; 抗氧化 ; 炎症因子 ; Icariin ; Neuroprotective effects ; Antioxidant ; Cytokine
刊名: 环球中医药
发表日期: 2014
DOI: 10.3969/j.issn.1674-1749.2014.04.018
期: 4, 页:300-304
收录类别: 中国科技核心期刊
文章类型: Journal Article
摘要: 淫羊藿苷是中药淫羊藿的主要活性成分,具有抗肿瘤、增强免疫、改善心脑血管、调节内分泌等多重药理学作用。近年来关于淫羊藿苷对中枢神经系统保护作用的研究日益增多,为了进一步推进淫羊藿苷对于防治中枢神经系统疾病的研究,本文结合近十年国内外对其保护神经元细胞的研究报道,系统地总结和陈述了淫羊藿苷发挥保护神经作用的几个途径,主要包括抗氧化应激、抑制炎症反应、影响单胺类递质及氨基酸类神经递质的释放、增加神经营养作用等几个方面,以及探讨了淫羊藿苷发挥神经保护作用的信号转导机制,为进一步推进淫羊藿苷的研究作出理论支持。 Icariin is one of the most dynamic composition of Epimedium, which has pharmacologi-cal functions of inhibiting tumor, enhancing immunity, improving heart and cerebral vessels, and regulating endocrine function. In recent years,researches on neuroprotective effects of icariin in central nervous sys-tem have been increased . To further promote the researches on prevention and cure on central nervous sys-tem diseases,this review systematically summarizes the neuroprotective effects of icariin on neurons inclu-ding the mechanism combined with research reports of Icariin at home and abroad, which include the fol-lowing, antioxigenic stess, inhibiting the inflammatory response, adjusting the release of neurotransmitter of monoamines and amino acids, and increasing neurotrophic effect. The signal transduction mechanism of icariin’s neuroprotective effect is also discussed, which may provide useful theoretical support to the re-search of icariin.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/42009
Appears in Collections:北京大学第一临床医学院_中医中西医结合科_期刊论文

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作者单位: 100034,北京大学第一医院中西医结合教研室
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