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学科主题: 中西医结合
题名:
荆花胃康胶丸联合三联疗法治疗幽门螺杆菌感染的1年随访研究
其他题名: Jinghua Weikang capsule combined with triple therapy in the treatment of Helicobacter pylori infection:a one-year follow up study
作者: 张月苗; 叶晖; 王婷婷; 张学智
关键词: 中成药 ; 幽门螺杆菌 ; 症状改善 ; 复发 ; Chinese patent medicine ; H.pylori ; improvement of dyspesia symptom ; relapse
刊名: 现代中医临床
发表日期: 2015
DOI: 10.3969/j.issn.2095-6606.2015.02.003
期: 2, 页:8-11
收录类别: 中国科技核心期刊
文章类型: Journal Article
摘要: 目的:在前期前瞻性研究结果基础上,比较荆花胃康胶丸联合三联疗法( helicobacter pylori, H.pylori)与铋剂四联疗法根除治疗幽门螺杆菌后患者远期消化不良症状改善和感染复发情况。方法对前期前瞻性研究中2012年9月至2013年11月于北京市5个中心就诊的H.pylori感染初治慢性胃炎患者在根除治疗H.pylori后进行为期1年的长期随访,分别对患者在停用根除治疗药物后1,6,12个月进行随访,记录患者消化不良症状,并分别于停药1,12个月后采用13 C-尿素呼气试验判断H.pylori根除和复发情况。结果共224例患者参加了研究,其中217例患者完成了1年的随访,荆花胃康组和铋剂四联组复查H.pylori 感染复发率分别为1.8%(2/113)和3.4%(2/59)。 H.pylori根除后1,6,12个月患者腹胀、嗳气、腹痛、纳差均较治疗前明显改善,差异均有统计学意义;荆花胃康组患者症状改善程度优于铋剂四联组,其中嗳气症状改善情况有统计学意义。结论荆花胃康胶丸联合三联疗法治疗H.pylori感染与铋剂四联疗法比较患者远期症状改善明显,根除治疗1年后H.pylori复发率相对较低。 Objective Based on the prospective study, this study alms to compare the effects of Jinghua Weikang capsules plus triple therapy and bismuch quadruple chemotherapy on dyspepsia symptoms and relapse of Helicobacter pylori ( H.pylori) after eradication.Methods In our previous study, patients with H.pylori infection were recruited from 5 hospitals from September 2012 to November 2013.The patients got H.pylori eradication therapies.1, 6 and 12 months after the eradication treatment, all the patients’ functional dyspepsia sympotoms were recorded and they underwent 13 C urea breath test at the 1st and 12th month respectively.Results 224 patients were enrolled in this study and 217 of them have finished the follow-up study.The relapse rate of H.pylori in Jinghua Weikang group and bismuch quadruple chemotherapy group were 1.8% (2/113) and 3.4% (2/59).The symptoms including abdominal distention, belching, stomachache and anorexia were improved significantly at 1, 6, and 12 months after the eradication of H.pylori, and the difference was significant ( P <0.001).And the improvements of Jinghua Weikang group were higher than those of bismuch quadruple chemotherapy group.There was statistical difference in the improvement of belching (P<0.05).Conclusions The symptomatic improvement of patients was better in Jinghua Weikang capsule combined with triple therapy while the relapse rate of H.pylori was relatively lower than bismuth quadruple chemotherapy.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/42059
Appears in Collections:北京大学第一临床医学院_中医中西医结合科_期刊论文

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作者单位: 北京大学第一医院中西医结合科,北京,100034
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