IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题放射医学
磁共振弥散加权成像在食管癌大体肿瘤靶区勾画中的应用价值
其他题名The application value of diffusion-weighted magnetic resonance imaging in gross tumor volume delineation of esophageal squamous cell carcinoma
侯栋梁1; 时高峰1; 高献书1; 李雪迎1; 刘辉1; 王亚宁1; 李月考1; 王琦1; 刘俊峰1; 刘庆熠1; 刘月平1; 姚晨1; 周志国1; 乔学英1
关键词食管肿瘤 磁共振弥散加权成像 靶区勾画 Esophageal Neoplasms Diffusion-weighted Magnetic Resonance Imaging Target Delineation
刊名中华放射肿瘤学杂志
2012
DOI10.3760/cma.j.issn.1004-4221.2012.04.016
21期:4页:343-347
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨磁共振弥散加权成像(DWMRI)在食管癌大体肿瘤体积(GTV)勾画中的应用价值.方法 29例行根治性食管癌切除术的食管鳞癌患者术前行常规CT、T2WI下MRI及DWMRI(弥散敏感梯度b=400、600、800 s/mm2),分别在上述3种图像上勾画GTV.测量3种方法GTV长度并与术后标本上测量的病变长度比较,以确定最佳方法和条件,并计算该条件下外扩范围满足GTV照射要求的患者比例.利用放疗计划系统的图像融合功能将不同b值下DWMRI图像与CT图像融合,验证融合图像上勾画GTV的可行性.结果 CT和T2WI下MRI图像上测量的GTV长度和标本上测量的病变长度差值分别为3.368 mm和2.84 mm;b=400、600、800 s/mm2时DWMRI图像上测量的GTV长度和标本上测量的病变长度差值分别为0.47、-0.47、-1.53 mm,其相关系数分别为0.928、0.927、0.938.DWMRI与CT图像在放疗计划系统中能很好融合,融合图像上食管癌病变两端分界清晰.结论 DWMRI能比较准确显示食管癌GTV长度和位置,利用放疗计划系统的图像融合功能可将DWMRI与CT图像进行融合并用于食管癌GTV勾画. Objective To analyze the application value of diffusion-weighted magnetic resonance imaging (DWMRI) in gross tumor volume (GTV) delineation of esophageal squamous cell carcinoma (SCC).Methods Twenty-nine patients with esophageal SCC treated with radical surgery were analyzed.Routine CT scan,MRI T2-weighted and DWMRI were employed before surgery;diffusion-sensitive gradient b-values were taken 400,600 and 800 s/mm2.GTVs were delineated using CT,MRI T2-weighted images and DWMRI under different b-value images.The length of GTVs measured under different images was compared with the pathological length and confirm the most accurate imaging condition.Use radiotherapy planning system to fuse DWMRI images and CT images to investigate the possibility of delineate GTVs on fused images.Results The difference of GTV length value between CT,T2 WI images and specimen was 3.36 mm and 2.84 mm.When b =400,600 and 800 s/mm2,the difference between GTV length value on the DWMRI images and on specimen was 0.47 mm,-0.47 mm and - 1.53 mm;the correlation coefficient of the measuring esophageal lengths on DWMRI images and the pathological lengths was 0.928,0.927 and 0.938.DWMRI images and CT images could fuse accurately on radiotherapy planning system.GTV margin could.show clearly on fused images.Conclusions DWMRI images can display the esophageal carcinoma lengths and margin accurately.When DWMRI images fused with CT images,GTV margin could show clearly,it can be used to delineate GTV accurately.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/42154
Collection北京大学第一临床医学院_放射治疗科
作者单位1.100034,北京大学第一医院故疗科
2.河北医科大学第四医院影像科
3.100034,北京大学第一医院医学统计室
4.河北医科大学第四医院胸外科
5.河北医科大学第四医院病理科
6.河北医科大学第四医院放疗科
Recommended Citation
GB/T 7714
侯栋梁,时高峰,高献书,等. 磁共振弥散加权成像在食管癌大体肿瘤靶区勾画中的应用价值[J]. 中华放射肿瘤学杂志,2012,21(4):343-347.
APA 侯栋梁.,时高峰.,高献书.,李雪迎.,刘辉.,...&乔学英.(2012).磁共振弥散加权成像在食管癌大体肿瘤靶区勾画中的应用价值.中华放射肿瘤学杂志,21(4),343-347.
MLA 侯栋梁,et al."磁共振弥散加权成像在食管癌大体肿瘤靶区勾画中的应用价值".中华放射肿瘤学杂志 21.4(2012):343-347.
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