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学科主题放射医学
前列腺癌放疗中前列腺体积缩小与新辅助内分泌治疗时间的关系研究
其他题名Relationship between prostate volume reduction and neoadjuvant hormone therapy duration in prostate cancer radiotherapy
李洪振; 高献书; 纪辰; 李晓颖; 秦尚彬; 亓昕; 王庆国; 张敏; 李晓梅
关键词前列腺肿瘤/放射疗法 前列腺肿瘤/新辅助内分泌疗法 前列腺体积 Prostate Neoplasms/radiotherapy Prostate Neoplasms/neoadjuvant Hormone Therapy Prostate Volume
刊名中华放射肿瘤学杂志
2015
5页:511-515
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的:探讨前列腺癌放疗中体积变化与新辅助内分泌治疗( NHT)之间的关系。方法55例接受NHT前列腺癌患者连续入组,放疗中每周测量前列腺左右、上下、前后方向直径并计算体积。分析放疗中前列腺缩小与NHT时间、放疗前体积及前列腺癌风险分组间关系。结果所有患者前列腺体积均随放疗进行而减小,NHT时间短者各项变化幅度大于时间长者。前列腺体积正常组与增大组比,前者在放疗7周后体积变化比例及各方向直径变化幅度均较大,且放疗前NHT时间较短,前列腺癌风险较低。与放疗前相比,中低危患者NHT≤4个月的体积分别缩小至68?10%、78?70%( P=0?002),而>4个月者变化较微弱;高危以上患者 NHT≤6个月的体积分别缩小至76?59%及85?46%( P=0?001),而>6个月者相近。结论 NHT时间越长,放疗中前列腺体积及各方向直径变化幅度越小。中低危前列腺癌患者NHT4个月以后前列腺体积的变化幅度较小,高危或局部进展期患者NHT时间6个月以后变化幅度较小。 Objective To study the relationship between changes in prostate volume and neoadjuvant hormone therapy ( NHT) duration in prostate cancer radiotherapy. Methods Fifty patients with prostate cancer who received NHT were enrolled in the study continuously. The diameters along the x?, y?, and z?axes of the prostate were measured, and the volume of prostate was calculated weekly during radiotherapy. The relationship of prostate volume reduction with NHT duration, prostate volume before radiotherapy, and prostate cancer risk groups was analyzed during radiotherapy. Results The prostate volume in all patients decreased after radiotherapy. Patients with short NHT duration had larger changes in prostate volume and diameters than those with long NHT duration. Compared with those with a large prostate volume, patients with a normal prostate volume had larger changes in prostate volume and diameters long three axes after 7 weeks of radiotherapy, shorter NHT duration before radiotherapy, and lower risk of prostate cancer. In patients with low?and medium?risk prostate cancer, the prostate volumes were significantly reduced to 68?10% and 78?70%, respectively, of those before radiotherapy after no more than 4 months of NHT ( P=0?002) , but remained similar after more than 4 months of NHT. In patients with high?risk and more severe prostate cancer, the prostate volumes were significantly reduced to 76?59% and 85?46%, respectively, of those before radiotherapy after no more than 6 months of NHT (P=0?001), but remained similar after more than 6 months of NHT. Conclusions The changes in prostate volume and diameters along three axes during radiotherapy become smaller with longer NHT duration. Patients with low?or medium?risk prostate cancer have slight changes in prostate volume after more than 4 months of NHT, while patients with high?risk or locally advanced prostate cancer have slight changes in prostate volume after more than 6 months of NHT.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/42163
专题北京大学第一临床医学院_放射治疗科
作者单位100034,北京大学第一医院放疗科
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李洪振,高献书,纪辰,等. 前列腺癌放疗中前列腺体积缩小与新辅助内分泌治疗时间的关系研究[J]. 中华放射肿瘤学杂志,2015(5):511-515.
APA 李洪振.,高献书.,纪辰.,李晓颖.,秦尚彬.,...&李晓梅.(2015).前列腺癌放疗中前列腺体积缩小与新辅助内分泌治疗时间的关系研究.中华放射肿瘤学杂志(5),511-515.
MLA 李洪振,et al."前列腺癌放疗中前列腺体积缩小与新辅助内分泌治疗时间的关系研究".中华放射肿瘤学杂志 .5(2015):511-515.
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