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学科主题: 放射医学
题名:
高强度聚焦超声联合放射治疗对猪胰腺及超声声窗组织与脏器损伤作用的观察研究
其他题名: Assessment of injury to the pancreas,the abdominal tissues and organs of swine in vivo by high intensity focused ultrasound combined with radiotherapy
作者: 刘朝兴1; 高献书1; 熊六林1; 葛辉玉1; 何新勇1; 张红娟1; 张志华1
关键词: 超声检查 ; 放射治疗 ; ; 胰腺 ; 损伤 ; Ultrasonography ; Radiotherapy ; Swine ; Pancreas ; Injuries and wounds
刊名: 中华医学超声杂志(电子版)
发表日期: 2010
DOI: 10.3877/cma.j.issn.1672-6448.2010.12.013
卷: 07, 期:12, 页:2055-2062
文章类型: Journal Article
摘要: 目的 观察高强度聚焦超声(HIFU)联合放射治疗对猪胰腺目标的治疗作用及腹部声窗上组织和脏器的损伤情况.方法 实验猪共12头,每组3头,分为对照组、HIFU组、放疗组和联合治疗组(HIFU与放疗).放射治疗及HIFU治疗均参照临床治疗参数进行,对大体标本根据不同损伤程度评为0~3分,组织病理学根据细胞变性坏死情况分为0~4分进行评分,根据损伤及评分情况评价胰腺目标及超声和放射治疗通路上组织、器官的损伤情况.结果 (1)胰腺损伤病理观察评分结果:联合治疗组评分值高于HIFU组,两组评分结果比较差异有统计意义(t=4.161,P=0.003).(2)胃壁损伤病理观察评分结果:联合治疗组评分值略高于HIFU组及放疗组,但评分结果比较差异无统计学意义.(3)肠壁损伤病理观察评分结果:联合治疗组及放疗组评分值均高于HIFU组,评分结果比较差异有统计学意义(t=2.827,P=0.022),联合治疗组与放疗组评分结果比较差异无统计学意义.各组实验动物耐受性好,未发生严重并发症.结论 与HIFU组及放疗组相比,对活体猪行HIFU联合放射治疗增加了在体胰腺组织的治疗性损伤作用;但HIFU联合放疗治疗未增加HIFU对非目标区组织的损伤,主要损伤表现与放射治疗有关. Objective To observe the injury of high intensity focused ultrasound combined with radiotherapy (RT) to the pancreas,the unintended abdominal tissues and organs of swine in vivo.MethodsAccording to the criterion to grade the gross and histological injury of the pancreas and the unintended tissue,the scores of injury between the groups to get the data of safety and feasibility of high intensity focused ultrasound(HIFU)combined with RT were compared.Results There was a better tolerance in each group and no fatal complication was observed.For the pancreas there was significant difference for the combined group compared with the other groups.For the unintended target tissue there was no significance difference except the control group with the other groups.Conclusion HIFU combined with RT can increase the injury to the pancreas of the swine compared with HIFU alone; while there was no increase for the injury to the unintended target tissue.The main toxicity of combination treatment is the toxicity of RT and can be tolerated by the animals.If the HIFU treatment is strictly controlled,the combination of HIFU and RT is safe and feasible.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/42181
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.北京大学第一医院放射治疗科,100034
2.北京大学第一医院泌尿外科,100034
3.北京大学第三医院超声科
4.河北省石家庄市第一医院
5.河北省胸科医院
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