多发性骨髓瘤（MM）是一种以单克隆浆细胞恶性增生并分泌大量单克隆免疫球蛋白为特点的血液系统恶性肿瘤。MM 相关骨病是 MM 最常见的合并症。约70%～80%的 MM 患者初诊时即检出骨损害。MM 相关骨病的治疗包括双膦酸盐、放射治疗、药物、外科手术等措施。
Multiple myeloma is a hematologic malignancy. It is characterized by a neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. Multiple myeloma-related bone disease is the most common complication of multiple myeloma. Osteolytic lesions are detected in 70% to 80% of patients at preliminary diagnosis. Treatments of myeloma-related bone disease include bisphosphonate therapy, radiation therapy, novel agents and surgical intervention.