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学科主题: 影像医学
题名:
不同对比剂对脑转移瘤MRI动态增强定量参数(Ktrans)的影响
其他题名: Influence of Different Contrast Agents on Dynamic Contrast-Enhanced MRI Ktrans in Cerebral Metastases: Comparison between 1.0 M Gadobutrol and 0.5M Gadopentetate Dimeglumine
作者: 范兵1; 杜华睿1; 王霄英1; 宛然1; 罗晶晶1; 张珏1
关键词: 钆布醇 ; 钆喷酸葡胺 ; 脑转移瘤 ; 容积转运常数 ; Gadobutrol ; Gadopentetate dimeglumine ; Cerebral metastases ; Volume transfer constant(Ktrans)
刊名: 临床放射学杂志
发表日期: 2014
卷: 33, 期:9, 页:1421-1424
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 比较不同浓度对比剂(钆布醇与钆喷酸葡胺)对脑转移瘤容积转移常数(Ktrans)的影响.方法 招募10例脑转移瘤患者,签署知情同意书,采用个体内自身随机对照研究,所有患者均接受2次头颅MRI动态增强检查,分别注射2种不同对比剂.采用交叉设计,利用随机表确定注射钆布醇和钆喷酸葡胺的次序,两次检查间隔24~ 48 h.对比剂剂量0.1 mmol/kg体重,注药流率3.0 ml/s,注射对比剂同时启动MR动态增强检查,对直径>5 mm的病灶测量Ktrans值及细胞外血管外间隙(Ve)值.使用SPSS 13.0进行统计学处理,对2种不同对比剂所测Ktrans值及Ve值分别采用方差分析,进一步做Pearson相关性分析,P<0.05认为有统计学差异.结果 2例患者因病灶较小(直径<5 mm)无法测量Krans值而排除,对8例患者共21个病灶进行分析,钆布醇及钆喷酸葡胺所测Ktrans值分别为(0.32±0.19) min-1,(0.35±0.19) min-1 (F=0.315,P>0.05),两者Ve值分别为0.89±0.10,0.88±0.09(F =0.009,P>0.05).两种对比剂所测Ktrans值及Ve值均呈正相关(Ktrans:r =0.712,P<0.001;Ve:r=0.616,P<0.05).结论 使用不同含钆对比剂(钆布醇与钆喷酸葡胺)行MR动态增强扫描,对脑转移瘤病灶所测Ktrans及Ve值具有相关性. Objective To explore the effect of different Gadolium-based contrast agents (gadobutrol vs.gadopentetate dimeglumine) on the measurement of volume transfer constant (Ktrans) and Ve in dynamic contrast enhanced MRI for cerebral metastases.Methods Ten patients with pathologically-confirmed cerebral metastases were examined by dynamic contrast-enhanced MR imaging with identical scanning protocol for two times.Gadobutrol or gadopentetate dimeglumine were randomly selected for the first study,with dosage of 0.1 mmol gadolium/kg body weight.Twenty-four to 48 hours later,the second study was performed with injection of the other contrast agent.The Ktrans and Ve values of the metastatic foci were obtained from the 2 sets of data.Paired t test and Pearson correlation analysis were used for statistical analysis.Results Two patients were excluded because the lesions were too small (diameter less than 5mm).Thus,8 patients (21 lesions in total) could be used for evaluation.The Ktrans values obtained with gadobutrol and gadopentetate dimeglumine contrast-enhanced dynamic MRI were (0.32 ±0.19) min-1 and (0.35 ±0.19) min-1,respectively.And the Ve values were (0.89 ±0.10) and (0.88 ±0.09),respectively.For both Ktrrans and Ve,Paired t test showed that no statistically significant differences existed between values obtained with the two different contrast agents.Both Ktrans and Ve measurements obtained with gadobutrol were correlated with measurements obtained with gadopentetate dimeglumine (Ktrans:r =0.712,P < 0.001 ;Ve:r =0.616,P < 0.05).Conclusion On dynamic contrast enhanced MRI for cerebral metastases,the Ktrans and Ve values that are measured when gadobutrol is used have good correlation to the Ktrans and Ve values that are measured when gadopentetate dimeglumine is used.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/42556
Appears in Collections:北京大学第一临床医学院_医学影像科_期刊论文

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