IR@PKUHSC  > 北京大学第一临床医学院  > 医学影像科
学科主题影像医学
MR波谱在预测前列腺癌转移中的作用
其他题名Prediction of metastasis of prostate cancer with three-dimensional proton MR spectroscopy:a preliminary study
李飞宇; 蒋学祥; 王霄英; 肖江喜
关键词前列腺肿瘤 磁共振波谱学 Roc曲线 Prostatic Neoplasms Magnetic Resonance Spectroscopy Roc Curve
刊名中华放射学杂志
2008
DOI10.3321/j.issn:1005-1201.2008.02.015
42期:2页:176-179
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨MR波谱(MRS)在预测前列腺癌转移中的价值.方法 65例超声引导下穿刺活检证实的前列腺癌患者,根据临床分期分为未发生转移组(B期和C期)31例和发生骨和(或)淋巴结转移组(D期)34例,通过MRS测定2组患者癌病灶区(胆碱+肌酸)/枸橼酸盐[(Cho +Cre)/Cit]的比值,并比较其差异.同时利用描绘受试者工作特征(ROC)曲线来初步评价MRS在预测前列腺癌发生转移中的效能.结果 未发生转移组和发生转移组患者的前列腺癌区(Cho+Cre)/Cit比值分别为1.3±0.5和2.2±0.6,差异有统计学意义(t=6.38,P<0.05).利用癌病灶区(Cho+Cre)/Cit的平均比值对肿瘤是否发生转移进行诊断试验,ROC曲线下面积(Az)值为0.87,最佳临界点为1.53,此时诊断的敏感性为94.12%(32/34),特异性为67.74%(21/31),准确性为81.54%(53/65).结论 MRS作为一种无创的MRS检查方法 ,有可能对肿瘤是否发生转移作出预测. Objective To determine if the three-dimensional proton magnetic resonance spectroscopic(MRS) imaging helps in diagnosing metastasis ofprostate cancer(Pca).Methods Sixty-five patients with biopsy proven Pca were recruited and divided into two groups:group 1 with metastasis(bone and/or lymph node metastasis)(n=34)and Group 2 without metastasis(n=31).Voxels were placed on cancerous area in peripheral zone and the ratios of(Cho+Cre)/Cit were measured.The mean ratio in each patient was calculated and ROC curve was drawn to determine the optimal operating point(OOP)for the prediction of Pca metastasis by the metabolite ratio.Results The mean ratio of(Cho+Cre)/Cit in cancerous area of Pca without metastasis was 1.3 ±0.5,whereas that of Pca with metastasis was 2.2±0.6.Statistically significant difference existed between the two groups(t=6.38,P<0.05).According to the ROC analysis,the OOP was determined and interpreted at 1.53 with higher sensitivity and specificity.If Pca with metastasis was predicted as whose the mean ratio of(Cho+Cre)/Cit in cancerous area larger than 1.53,the sensitivity,specificity and accuracy for metastasis determination were 94.12%(32/34),67.74%(21/31),and 81.54%(53/65)respectively.Conclusion MRS may be a useful noninvasive method to predict the metastasis of Pca.
语种中文
原文出处查看原文
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/42653
Collection北京大学第一临床医学院_医学影像科
作者单位北京大学第一医院医学影像科,100034
Recommended Citation
GB/T 7714
李飞宇,蒋学祥,王霄英,等. MR波谱在预测前列腺癌转移中的作用[J]. 中华放射学杂志,2008,42(2):176-179.
APA 李飞宇,蒋学祥,王霄英,&肖江喜.(2008).MR波谱在预测前列腺癌转移中的作用.中华放射学杂志,42(2),176-179.
MLA 李飞宇,et al."MR波谱在预测前列腺癌转移中的作用".中华放射学杂志 42.2(2008):176-179.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[李飞宇]'s Articles
[蒋学祥]'s Articles
[王霄英]'s Articles
百度学术
百度学术Similar articles in
[李飞宇]'s Articles
[蒋学祥]'s Articles
[王霄英]'s Articles
必应学术
必应学术Similar articles in
[李飞宇]'s Articles
[蒋学祥]'s Articles
[王霄英]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.