IR@PKUHSC  > 北京大学第一临床医学院  > 医学影像科
学科主题影像医学
乳腺癌新辅助化疗前后MR表观扩散系数变化与病理反应性分级的相关性研究
其他题名Prediction of response of breast cancer to neoadjuvant chemotherapy by MR diffusion-weighted imaging:a study of correlation between apparent diffusion coefficient value and pathologic response
武春雪1; 王霄英1; 秦乃姗1; 李挺1; 张虹1; 刘荫华1; 徐玲1; 蒋学祥1
关键词乳腺肿瘤 药物疗法 联合 磁共振成像 扩散 Breast Neoplasms Drug Therapy Combination Diffusion Magnetic Resonance Imaging
刊名中华放射学杂志
2009
DOI10.3760/cma.j.issn.1005-1201.2009.12.013
43期:12页:1286-1290
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 研究乳腺癌患者新辅助化疗前、后各周期ADC值及其变化率(△ADC%),探讨两种参数对新辅助化疗病理反应性评估的价值.方法 35例穿刺活检证实为乳腺癌的患者分别于新辅助化疗前、化疗第2和第3周期之间、化疗第4周期后行MR DWI及增强扫描,根据其术后病理对化疗反应的分级将其分为组织学反应显著(MHR)与非显著(NMHR)2组,利用重复测量的单因素方差分析及t检验分析2组患者癌灶区与对应正常腺体的ADC值,采用秩和检验分析3次ADC值及△ADC%,并应用ROC分析其对病理反应性评估的效能.结果 MHR组的乳腺癌灶手术前ADC值[中位数(范围)]为1.54×10~(-3)mm~2/s[(1.01~1.88)× 10~(-3)mm~2/s],△ ADC%为42.70%(6.31%~67.86%);在化疗第4周期后明显高于NMHR组的1.22 × 10~(-3)mm~2/s[(0.83~1.83)×10~(-3)mm~2/s]和14.88%(-28.87%~39.69%),差异有统计学意义(Z值分别为-2.77、-4.10,P值均<0.05),而化疗早期MHR组ADC值为1.15×10~(-3)mm~2/s[(0.85~1.62)× 10~(-3)mm~2/s],△ADC%值为12.00%(-12.96%~30.65%);NMHR组ADC值为1.15×10~(-3)mm~2/s[(0.94~1.60)×10~(-3)mm~2/s],△ ADC%值为10.74%(-20.80%~41.81%);2组差异无统计学意义(P>0.05).分别以病灶ADC及△ADC%为评估值,对MHR和NMHR组进行ROC分析,其中只有△ ADC3%的评估效能较高(Az△ADC3%=0.88).结论 化疗晚期△ADC%可以较准确预测乳腺癌对新辅助化疗的最终病理反应性. Objective To characterize the value of ADC and their changes (⊿ADC%) before and during the neoadjuvant chemotherapy,and their value in predicting the pathologic response of breast cancer to neoadjuvant chemotherapy. Methods Diffusion weighted imaging and dynamic contrast enhanced magnetic resonance examinations were performed in 35 women with breast cancer before treatment and after the second and the forth cycle of neoadjuvant chemotherapy.All patients were divided into MHR (major histological response) group and NMHR (non-major histological response) group according to the final pathologic response.One-way ANOVA and t test were used to compare the differences of cancer tissue and normal tissue.Rank sum test was used to compare the difference of ADC and ⊿ADC% between two groups.ROC analysis of ADC values and ⊿ADC% were used to identify which parameter could be used to predict the pathologic response to neoadjuvant chemotherapy.Results After the forth cycle,the ADC value and ⊿ADC% in MHR group [1.54×10~(-3) mm~2/s (1.01-1.88)×10~(-3) mm~2/s and 42.70% (6.31%-67.86%)]were significant higher than those in NMHR group [1.22×10~(-3) mm~2/s (0.83-1.83)×10~(-3) mm~2/s,14.88%(-28.87%-39.69%,P<0.05)].However,the ADC value and ⊿ADC% in the two groups were not different before treatment and after second cycle treatment:1.15×10~(-3) mm~2/s(0.85-1.62)×10~(-3) mm~2/s and 12.00%(-12.96%-30.65%)in MHR;1.15×10~(-3) mm~2/s(0.94-1.60)×10~(-3) mm~2/s and 10.74%(-20.80%-41. 81%,P<0.05)in NMHR.Only the ⊿ADC_3% showed high efficacy in predicting the pathologic response(area under ROC curve was 0.88).Conclusion The rate of ADC change in late cycle could be used to predict the pathologic reaponse of breast cancer to neoadjuvant chemotherapy.
语种中文
原文出处查看原文
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/42869
Collection北京大学第一临床医学院_医学影像科
作者单位1.北京大学第一医院医学影像科北京大学前沿交叉学科研究院功能成像研究中心,100034
2.北京大学第一医院医学影像科北京大学前沿交叉学科研究院功能成像研究中心病理科,100034
3.北京大学第一医院医学影像科北京大学前沿交叉学科研究院功能成像研究中心乳腺中心,100034
Recommended Citation
GB/T 7714
武春雪,王霄英,秦乃姗,等. 乳腺癌新辅助化疗前后MR表观扩散系数变化与病理反应性分级的相关性研究[J]. 中华放射学杂志,2009,43(12):1286-1290.
APA 武春雪.,王霄英.,秦乃姗.,李挺.,张虹.,...&蒋学祥.(2009).乳腺癌新辅助化疗前后MR表观扩散系数变化与病理反应性分级的相关性研究.中华放射学杂志,43(12),1286-1290.
MLA 武春雪,et al."乳腺癌新辅助化疗前后MR表观扩散系数变化与病理反应性分级的相关性研究".中华放射学杂志 43.12(2009):1286-1290.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[武春雪]'s Articles
[王霄英]'s Articles
[秦乃姗]'s Articles
百度学术
百度学术Similar articles in
[武春雪]'s Articles
[王霄英]'s Articles
[秦乃姗]'s Articles
必应学术
必应学术Similar articles in
[武春雪]'s Articles
[王霄英]'s Articles
[秦乃姗]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.