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IR@PKUHSC  > 北京大学第一临床医学院  > 医学影像科  > 期刊论文
学科主题: 影像医学
题名:
体素内不相干运动扩散加权成像对前列腺癌的诊断价值
其他题名: Preliminary study of intravoxel incoherent motion diffusion-weighted imaging of prostate cancer
作者: 叶锦棠; 蔡文超; 王岳; 王霄英
关键词: 前列腺肿瘤 ; 磁共振成像 ; 扩散加权成像 ; 诊断,鉴别 ; Prostate neoplasms ; Magnetic resonance imaging ; Diffusion-weighted imaging ; Diagnosis,differential
刊名: 放射学实践
发表日期: 2014
期: 5, 页:474-476
收录类别: 中国科技核心期刊
文章类型: Journal Article
摘要: 目的:探讨多b值扩散加权成像(DWI)序列在前列腺癌诊断中的应用价值。方法:经超声引导下行前列腺穿刺活检病理证实为前列腺癌的7例患者及非前列腺癌的4例患者纳入本组研究,所有患者均行多b 值D WI序列(b 值分别为0、188、375、563和750 s/mm2)扫描。应用双指数模型(体素不相干运动模型)进行分析,计算并比较分析前列腺癌区和非癌区的相对纯扩散值D 和灌注分数 f 的差异。结果:癌区的 D 值和 f 值分别为(0.77±0.20)×10-3 mm2/s 和(8.66±3.07)%,非癌区的D值和f值分别为(1.53±0.48)×10-3mm2/s 和(2.27±1.16)%。癌区的D值低于非癌区,差异有统计学意义(P<0.01);癌区的f值高于非癌区,但差异无统计学意义(P>0.05)。结论:多b 值DWI 序列可获取前列腺组织真实水分子扩散运动及微灌注相关信息,可为前列腺癌的诊断提供重要信息。 Objective:To determine the role of multi b-value DWI in the evaluation of prostate cancer (PCa).Methods:Seven patients with PCa and four patients without PCa according to the results of biopsy were recruited in the study.All ofthem underwent the multi b-value DWI (b=0,1 88,37 5,56 3,750s/mm2 )examination on a 3 .0T MR scanner.Quantitativeanalysis was conducted by using an intravoxel incoherent motion (IVIM)bi-exponential model.Then the pure diffusion coefficient(D)and perfusion fraction (f)in the cancerous and noncancerous areas were calculated and compared (independentt-test)between the two groups.Results:The D and f values in the cancerous areas were (0.7 7 ±0.20)×1 0 -3 mm2/s and(8.6 6 ±3 .07 )%,whereas the D and f values in the noncancerous areas were (1 .5 3 ±0.48 )× 1 0 -3 mm2/s and (2 .2 7 ±1 .1 6)%.The D values in the cancerous areas were significantly lower than those of the noncancerous areas (P <0.0 1 ).Thef values in the cancerous areas were higher than those of noncancerous areas but there was no statistical difference betweenthe two groups.Conclusion:Multi b-value DWI can reflect the true water diffusion motion and microcirculation perfusion inthe prostate.It may be a feasible tool in the diagnosis of prostate cancer.
语种: 中文
原文出处: 查看原文
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/42912
Appears in Collections:北京大学第一临床医学院_医学影像科_期刊论文

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作者单位: 北京大学第一医院医学影像科, 北京,100034
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