北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科  > 期刊论文
学科主题: 核医学
题名:
18F-FDG PET/CT评价初诊非霍奇金淋巴瘤代谢活性及其与免疫表型的相关性
其他题名: Metabolic activity measured by 18F-FDG PET/CT in newly diagnosed patients with non-Hodgkin lymphoma: correlation with immunophenotype
作者: 张建华; 王荣福; 范岩; 付占立; 张旭初; 廖栩鹤; 刘萌; 康磊; 崔永刚
关键词: 淋巴瘤,非霍奇金 ; 正电子发射断层显像术 ; 氟脱氧葡萄糖F18 ; Lymphoma,non-Hodgkin ; Positron-emission tomography ; Fluorodeoxyglucose F18
刊名: 中华医学杂志
发表日期: 2014
DOI: 10.3760/cma.j.issn.0376-2491.2014.33.006
卷: 94, 期:33, 页:2576-2579
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 对比分析初诊不同亚型非霍奇金淋巴瘤(NHL)患者病灶的代谢活性,探讨其与免疫表型之间的相关性.方法 回顾性分析北京大学第一医院核医学科2010年7月至2012年3月行18氟-氟代脱氧葡萄糖(18F-FDG) PET/CT显像的NHL患者资料.测量反映肿瘤代谢活性的最大标准化摄取值(SUVmax),分析惰性B细胞NHL、侵袭性B细胞NHL及T细胞NHL SUVmax平均值之间的差异及SUVmax与免疫表型之间的相关性.结果 本组患者中,NHL SUVmax 0.9~40.3不等,96.3%(79/82)的患者病灶均可见较明显的18F-FDG摄取.同一淋巴瘤亚型之间SUVmax也明显不同.惰性B细胞NHL、侵袭性B细胞NHL、T细胞NHL SUVmax分别为4.5±2.4、13.1士7.6、8.0士3.8.惰性B细胞NHL SUVmax低于侵袭性B细胞NHL、T细胞NHL(P=0.000、P=0.03);侵袭性B细胞NHL SUVmax高于惰性B细胞NHL、T细胞NHL SUVmax(P=0.000、P=0.005).B细胞NHLSUVmax与Ki-67阳性率呈正相关(r=0.493,P=0.001),与CD138表达呈负相关(r=-0.654,P=0.008).T细胞NHL SUVmax与Ki-67阳性率无相关(P =0.213),与CD56表达呈负相关(r=-0.545,P=0.044).结论 不同NHL亚型FDG摄取明显不同,多数亚型呈FDG高摄取.惰性B细胞NHL代谢活性明显低于侵袭性B细胞NHL、T细胞NHL,侵袭性B细胞NHL代谢活性高于惰性B细胞NHL、T细胞NHL.B细胞NHL SUVmax与Ki-67表达呈正相关,与CD138表达呈负相关;T细胞NHL SUVmax与Ki-67表达无相关性,与CD56表达呈负相关. Objective To compare the metabolic activity by 18F-fluorodeoxyglucose (18F-FDG)uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) and to investigate the relationship between metabolic activity and immunophenotype.Methods Positron emission tomography/computed tomography (PET/CT) studies of patients with newly diagnosed NHL from Jul 2010 to Mar 2012 were retrospectively reviewed,82 patients were enrolled in our study according to the inclusion and exclusion criteria.The maximum standardized uptake value (SUVmax) of each patient reflecting the metabolic activity was recorded.Mean SUVmax of aggressive B-cell NHL,indolent B-cell NHL and T-cell NHL were compared.Pearson and Spearman test were used to analyze the relationship between SUVmax and immunophenotype.Results The SUVmax of various subtypes of lymphoma revealed a wide range from 0.9 to 40.3,but lesions of 79 patients in this study showed obviously FDG uptake.SUVmax of indolent B-cell NHL (4.5 ±2.4) was significantly lower than that of aggressive B-cell NHL (13.1 ±7.6) (P =0.000),T-cell NHL (8.0 ± 3.8) (P =0.03).SUVmax of aggressive B-cell NHL was significantly higher than that of indolent B-cell NHL,T-cell NHL (P =0.000,P =0.005).SUVmax of B-cell NHL had positive correlation with Ki-67 expression (r =0.493,P =0.001) and negative correlation with CD138 (r =-0.654,P =0.008).While SUVmax of T-cell NHL had no correlation with Ki-67 expression (P =0.213),but had negative correlation with CD56 (r =-0.545,P =0.044).Conclusions Different subtype of NHL manifests markedly different intensity of FDG uptake,but most lesions of lymphoma are FDG avid.Metabolic activity is lower in indolent B-cell NHL than in aggressive B-cell NHL and T-cell lymphoma,which is concordant with its aggressiveness.SUVmax of B-cell NHL correlates with expression of Ki-67 and CD138.SUVmax of T-cell NHL is associated with the expression of CD56,no correlation is detected between SUV max of T-cell NHL and Ki-67 proliferation.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/43228
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 100034,北京大学第一医院核医学科
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[张建华]'s Articles
[王荣福]'s Articles
[范岩]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[张建华]‘s Articles
[王荣福]‘s Articles
[范岩]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace