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学科主题: 病理学
题名:
皮肤非朗格汉斯树突细胞组织细胞增生症:一个新病种?
其他题名: Cutaneous dendritic ceil-derived non-Langerhans cell histiocytosis: a new entity?
作者: 农琳1; 赵邑1; 任雅丽1; 涂平1; 熊焰1; 张爽1; 朱学骏1; 李挺1
关键词: 皮肤 ; 树突细胞 ; 组织细胞增多症 ; Skin ; Dendritic cells ; Histiocytosis
刊名: 中华皮肤科杂志
发表日期: 2008
DOI: 10.3321/j.issn:0412-4030.2008.10.006
卷: 41, 期:10, 页:653-656
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 患者男,57岁,全身斑块进行性增多7年,面部、躯干和四肢多发大小不等红色结节和浸润性斑片.组织病理学检查示真皮全层弥漫散在分布的多形性肿瘤细胞,呈低密度增生状态.部分可见细胞突起,使细胞呈多角状.免疫组化CD45、FXIIIa、CDl4、MHC-Ⅱ、CD68、溶菌酶阳性,并有细胞外间质表达,CDla、S-100阴性.电镜下细胞突起,核形不规则,胞质及基质中弥漫分布膜包绕低密度囊泡结构,无Birbeck颗粒.本例为一种罕见的皮肤非朗格汉斯组织细胞增生症,临床呈惰性侵袭性经过,可能起源于不成熟的真皮树突细胞. A 57-year-old man was admitted to the hospital for a 7-year progressively spreading plaques involving the entire body surface, and multiple irregularly sized red nodules and infiltrated patches on the face, trunk and limbs. Histopathological examination showed pleomorphic tumor cells diffusely dis-persed throughout the dennis, giving an appearance of low proliferation. Some cells with cytoplasmic pro-cesses appeared multiangular in shape, lmmunohistochemically, tumor cells were negative for CDla or S-100, but positive for CD45, FXIIIa, CDl4, MHC- Ⅱ, CD68 and lysozyme with extracellular interstitial expression. Ultrastructurally, the cells exhibited cytoplasmic processes and irregularly sized nuclei; no Birbeck granules were observed. Vesicules of low electron-density were seen diffusely in cytoplasm and extracellular matrix. The case is herein diagnosed as cutaneous non-Langerhans cell histiocytosis, which presents with a chronically invasive clinical course. These cells may develop from immature dermal dendritic cells.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/43328
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: 1.北京大学第一医院病理科,100034
2.北京大学第一医院皮肤科,100034
3.北京大学第一医院电镜室,100034

Recommended Citation:
农琳,赵邑,任雅丽,等. 皮肤非朗格汉斯树突细胞组织细胞增生症:一个新病种?[J]. 中华皮肤科杂志,2008,41(10):653-656.
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