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学科主题: 临床检验诊断学
题名:
半胱氨酸蛋白酶抑制剂C在评价老年人肾小球滤过功能中的应用价值
其他题名: Evaluation of serum Cystatin C in elderly patients as a marker for renal filtration function
作者: 刘静霞; 李淑葵; 徐国宾
关键词: Cystatin C肌酐 ; 肌酐清除率 ; 肾小球滤过率 ; 免疫散射浊度法 ; Cystatin C ; creatinine ; creatinine clearance ; glomerular filtration rate ; immunonephelometry
刊名: 中国现代医学杂志
发表日期: 2004
DOI: 10.3969/j.issn.1005-8982.2004.14.001
卷: 14, 期:14, 页:1-3,8
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C)对评价老年人肾小球滤过功能的临床应用价值.方法采用胶乳颗粒增强的免疫散射浊度法测定189例患各种肾脏病及相关疾病60岁以上老年患者的血清Cystatin C水平,同时测定了他们的血清肌酐及肌酐清清除率(Ccr),分别对血清Cystatin C和血清肌酐与肌酐清除率进行相关性分析.结果老年患者的血清Cystatin C与肌酐有显著正相关(P<0.001),与Ccr的对数呈显著负相关(P<0.001),回归方程分别为:Cystatin C=0.0112 Cr+0.2604(r=0.92)和Cystatin C=-3.406logCcr+7.593(r=-0.814).当Ccr(50~80)ml/min时,Cystatin C异常率(77.9%)高于肌酐异常率(9.1%).结论血清Cystatin C可作为老年人肾小球滤过功能指标,并可能比肌酐更能真实地反映老年人的肾小球滤过功能. Objective: To study the clinical significance of serum Cystatin C in evaluation of renal filtration function in elderly patients. Methods: A particle-enhanced nephelometric immunoassay (PENIA) was used to measure concentration of serum cystatin C. We determined the correlation between cystatin C and levels of serum creatinine (Scr) and creatinine clearance (Ccr) in189 cases of elderly patients. Results: There was a significant positive correlation between serum cystatin C and serum creatinine level (r=0.92, P<0.001). Significant negative correlation was observed between serum cystatin C and logCcr (r=-0.814, P<0.001). When Ccr was 50~80 ml/min, the abnormal rate of cystatin C (77.9%) was far higher than that of creatinine (9.1%).Conclusions: Serum cystatin C seems to be an attractive alternative and more accurate than serum creatinine for the estimation of GFR in elderly patients.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/43623
Appears in Collections:北京大学第一临床医学院_检验科_期刊论文

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作者单位: 北京大学第一医院检验科,北京,100034

Recommended Citation:
刘静霞,李淑葵,徐国宾. 半胱氨酸蛋白酶抑制剂C在评价老年人肾小球滤过功能中的应用价值[J]. 中国现代医学杂志,2004,14(14):1-3,8.
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