北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 药剂科  > 期刊论文
学科主题: 药剂学
题名:
利格列汀治疗2型糖尿病安全性的系统评价
其他题名: Safety of Linagliptin for Type 2 Diabetes Mellitus:a Systematic Review
作者: 杨婷; 路敏; 周颖; 崔一民
关键词: 利格列汀 ; 安全性 ; 2型糖尿病 ; Meta分析 ; Linagliptin ; Safety ; Type 2 Diabetes Mellitus ; Meta-analysis
刊名: 药品评价
发表日期: 2013
期: 6, 页:16-20
文章类型: Journal Article
摘要: 目的:评价二肽基肽酶-4抑制剂利格列汀治疗2型糖尿病的安全性.方法:在Cochrane图书馆、PubMed、EMBase、Medline、 CNKI、VIP和CBM数据库中检索利格列汀的随机对照试验(RCT),根据Cochrane 系统评价的原理和方法,评价RCT的质量,并使用Cochrane 协作网提供的RevMan 5.2软件进行Meta分析.结果:共纳入10个RCT研究,利格列汀单药治疗或联合治疗,试验组和对照组不良反应和严重不良反应的发生率相似,无显著性差异.常见不良反应包括低血糖、鼻咽炎、上呼吸道感染和头痛等,其中上呼吸道感染的发生率试验组高于安慰剂组,其它不良反应的发生率,试验组与安慰剂组相似.结论:利格列汀治疗2型糖尿病的安全性良好,但纳入研究的随访时间较短,其长期安全性有待验证. @@@@[Absract] Objective:To evaluate the safety of the dipeptidyl peptidase-4 inhibitor linagliptin in patients with type 2 diabetes mellitus(T2DM). Methods: Randomized controlled trials(RCTs)of linagliptin were retrieved from the Cochrane Library, PubMed, EMBase, Medline, CNKI, VIP and CBM databases. According to the principles and methods of Cochrane systematic reviews, the included RCTs were assessed and analyzed by the software RevMan 5.2 provided by the Cochrane Collaboration. Results: Ten studies were included. For the incidence of adverse events(AEs)and serious adverse events(SAEs), the linagliptin-treated group as monotherapy or combination therapy was similar to the placebo-treated group. Common AEs included hypoglycaemia, nasopharyngitis, upper respiratory tract infection(URTI)and headache. URTI presented a higher incidence in the experimental group than the control group, but other AEs demonstrated similar frequency. Conclusions:This study shows that linagliptin is safe for T2DM, but the long-term safety needs further confirmation.
语种: 中文
原文出处: 查看原文
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/43941
Appears in Collections:北京大学第一临床医学院_药剂科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 北京大学第一医院药剂科,北京100034

Recommended Citation:
杨婷,路敏,周颖,等. 利格列汀治疗2型糖尿病安全性的系统评价[J]. 药品评价,2013(6):16-20.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[杨婷]'s Articles
[路敏]'s Articles
[周颖]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[杨婷]‘s Articles
[路敏]‘s Articles
[周颖]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace