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IR@PKUHSC  > 北京大学第一临床医学院  > 药剂科  > 期刊论文
学科主题: 药剂学
题名:
中国健康受试者单剂量静脉注射比阿培南的药代动力学
其他题名: Pharmacokinetics of biapenem injection after a single dose administration in Chinese healthy subjects
作者: 周颖1; 许俊羽1; 赵侠1; 孙培红1; 张慧琳1; 崔一民1; 赵敏1; 张勇1
关键词: 比阿培南 ; 药代动力学 ; 高效液相色谱-紫外法 ; biapenem ; pharmacokinetic ; HPLC-UV
刊名: 中国临床药理学杂志
发表日期: 2010
DOI: 10.3969/j.issn.1001-6821.2010.04.004
卷: 26, 期:4, 页:255-258
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 研究中国健康受试者单剂量静脉注射比阿培南(碳青霉烯类抗生素)的药代动力学及安全性.方法 10名健康受试者分别静脉注射比阿培南300,600 mg 1 h,于1周后交叉注射另一剂量,用高效液相色谱-紫外法测定血浆和尿液中比阿培南的浓度,用WinNonLin计算其主要药代动力学参数.结果 10名受试者分别单剂量使用比阿培南300和600 mg后,比阿培南主要药代动力学参数:C_(max)分别为(11.33±2.71)和(26.80±5.11)μg·mL~(-1);AUC_(0-tn)分别为(18.01±4.66)和(42.78±-8.81)μg·mL~(-1)·h.结论 中国健康受试者单剂量使用比阿培南后,在300~600 mg内的体内过程呈线性药代动力学特征. Objective To study the pharmacokinetics and safety in healthy volunteers following intravenous administration of biapenem.Methods Ten healthy volunteers were randomized to administer a single dose of biapenem at 300 and 600 mg,respectively.They were given the other dose after a week.The concentration of biapenem in human plasma and urine were determined by HPLC-UV.The main pharmacokinetic parameters were calculated with WinNonLin.Results The main pharmacokinetic parameters of biapenem after single doses of 300 and 600 mg were as follows C_(max) were(11.33±2.71)and(26.80±5.11)μg·mL~(-1);AUC_(0-tn) were(18.01±4.66)and(42.78±8.81)μg·mL~(-1)·h,respectively.Conclusion The process of biapenem in the dosage range of 300-600 mg fit linear dynamic feature.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/43988
Appears in Collections:北京大学第一临床医学院_药剂科_期刊论文

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作者单位: 1.北京大学,第一医院药剂科,北京,100034
2.天津天士力集团有限公司,研究院,天津,300410

Recommended Citation:
周颖,许俊羽,赵侠,等. 中国健康受试者单剂量静脉注射比阿培南的药代动力学[J]. 中国临床药理学杂志,2010,26(4):255-258.
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