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学科主题: 药理学
题名:
2012年度全国细菌耐药监测报告:三级医院非重症监护病房住院患者细菌耐药监测
其他题名: China antimicrobial resistance surveillance system annual report of 2012:surveillance of antimicrobial resistance in non -intensive care unit inpatients of first-class hospitals
作者: 侯芳; 郑波; 吕媛
关键词: 非重症监护病房住院患者 ; 细菌耐药监测 ; 抗菌药物 ; non-intensive care unit inpatients ; bacterial resistance surveillance ; antibacterial
刊名: 中国临床药理学杂志
发表日期: 2015
DOI: 10.13699/j.cnki.1001-6821.2015.11.019
期: 11, 页:964-969
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:监测2012年我国主要城市三级医院非重症监护病房( ICU)住院患者临床分离细菌耐药状况。方法收集2012年我国557家三级医院非ICU住院患者临床分离细菌,统一用纸片扩散法、微量稀释法或E-test法测定细菌药物敏感性,用WHONET 5.6软件对药物敏感性进行分析。结果全国三级医院非ICU住院患者临床分离细菌596531株,标本分布前5位为痰、尿、血、分泌物和脓。甲氧西林耐药金黄色葡萄球菌和甲氧西林耐药凝固酶阴性葡萄球菌分离率分别为42.0%和73.6%。未发现万古霉素和利奈唑胺耐药葡萄球菌。粪肠球菌和屎肠球菌对氨苄西林的耐药率分别为11.2%和84.4%,对万古霉素的耐药率分别为1.1%和3.0%。铜绿假单胞菌对亚胺培南的耐药率为23.0%,鲍曼不动杆菌对亚胺培南的耐药率为33.0%。大肠埃希菌对头孢噻肟和亚胺培南的耐药率分别为69.3%和3.5%。肠杆菌科细菌对碳青霉烯类药物仍然高度敏感。结论我国细菌耐药状况严重,整体水平与上一年度近似。 ; Objective To explore the bacterial drug resistance and its epidemic trend in non-intensive care unit( ICU) inpatients of first class hospitals in China for clinical reference in the use of antibacterial agents.Methods All of the bacterial susceptibility results from non-ICU inpa-tients of 557 first class hospitals from Jan 1 to Dec 31 , 2012 were collect-ed by unified protocol and the data were analyzed by software WHONET 5.6.The disc -diffusion or automatic clinical microbiological system method was used for the bacterial sensitivity.Results A total of 596531 bacterial isolates and their antibacterial susceptibility data were collected during the survey period.The top 5 specimen were sputum, urine, blood, secretion and pus.The incidences of methicillin-resistant Staphy-lococcus aureus ( MRSA ) and methicillin -resistant coagulase negative staphylococcus ( MRSCN ) were 42.0% and 73.6%, respectively.No vancomycin resistant Staphylococcus strains were found.There were 11.2% of Enterococcus faecalis and 84.4% of Enterococcus faecium resistant to ampicillin.1.1% of Enterococcus faecalis and 3.0% of En-terococcus faecium were resistant to vancomycin.23.0%of Pseudomonas aeruginosa strains and 33.0% of Acinetobacter baumannii strains were resistant to Imipenem, respectively.69.3% of Escherichia coli were resistant to cefotaxime and 3.5% to imipe-nem, respectively.Isolates of Enterobacteriaceae were still highly sensitive to imipenem and meropenem.Conclusion Bacterial resistance in non-ICU inpatients was common and bacterial resistance rate was similar to that in last year.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44304
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 北京大学 第一医院 临床药理研究所,北京,100034

Recommended Citation:
侯芳,郑波,吕媛. 2012年度全国细菌耐药监测报告:三级医院非重症监护病房住院患者细菌耐药监测[J]. 中国临床药理学杂志,2015(11):964-969.
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