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IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所  > 期刊论文
学科主题: 药理学
题名:
头孢他美酯与头孢克肟治疗急性细菌性感染多中心临床试验
其他题名: Multicenter clinical trial of cefetamet pivoxil vs cefixime in treatment of acute bacterial infections
作者: 李家泰1; 赵彩芸1; 胡文芝1; 刘德梦1; 顾俊明1; 霍丽1
关键词: 头孢他美 ; 头孢克肟 ; 细菌性感染 ; 临床试验
刊名: 中国新药与临床杂志
发表日期: 2001
DOI: 10.3969/j.issn.1007-7669.2001.02.002
卷: 20, 期:2, 页:87-90
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:比较头孢他美酯与头孢克肟治疗急性细菌性感染的安全性、有效性。方法:多中心随机对照开放临床试验,头孢他美酯组98例(男性43例,女性55例,年龄40 a± s 13 a),用头孢他美酯250~500 mg,po, bid,头孢克肟组95例(男性44例,女性51例,年龄42 a±14 a),用头孢克肟200 mg, po, bid,疗程均为7~14 d。结果:2组临床总有效率分别为95%与94%,细菌清除率分别为96%与94%,细菌高度敏感百分率分别为98%与96%,不良反应发生率分别为7%与6%,经统计学处理差异均无显著意义(P>0.05)。结论:头孢他美酯与头孢克肟治疗急性细菌性感染安全、有效。 AIM: To evaluate the safety and efficacy of cefetamet pivoxil vs cefixime in the treatment of acute bacterial infections.  METHODS: A multicenter randomized controlled clinical trial was conducted. Ninety-eight patients (M 43, F 55; age 40 a± s 13 a) with acute bacterial infections of cefetamet group were given cefetamet pivoxil 250-500 mg, po, bid, for 7-14 d, and ninty-five patients (M 44, F 51; age 42 a±14 a) of cefixime group were given cefixime 200 mg, po, bid, for 7-14 d. RESULTS: The overall clinical efficacy rates were 95 % and 94 %, the bacterial clearance rates were 96 % and 94 %, the bacterial sensitive rates were 98 % and 96 %, the adverse reaction rates were 7 % and 6 %, respectively. There was no statistical significance between two groups (P>0.05). CONCLUSION: Cefetamet pivoxil and cefixime are effective and safe in the treatment of acute bacterial infections.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44380
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.北京大学第一医院 临床药理研究所,
2.天津医科大学附属第二医院,
3.大连医科大学附属第二医院,

Recommended Citation:
李家泰,赵彩芸,胡文芝,等. 头孢他美酯与头孢克肟治疗急性细菌性感染多中心临床试验[J]. 中国新药与临床杂志,2001,20(2):87-90.
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