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学科主题: 药理学
题名:
银花泌炎灵体外抗菌作用研究
其他题名: In vitro activity of Yinhua Miyan Ling
作者: 李耘; 吕媛; 刘健; 薛峰; 杨维维; 张佳
关键词: 银花泌炎灵 ; 体外抗菌活性 ; 联合药敏 ; Yihua Miyan Ling ; in vitro activity ; combination effect
刊名: 中国临床药理学杂志
发表日期: 2015
DOI: 10.13699/j.cnki.1001-6821.2015.04.013
期: 4, 页:279-282
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:评价银花泌炎灵体外抗菌活性及与临床常用抗菌药物的体外联合作用。方法对来自全国18家医院近3年临床分离的285株菌进行了最低抑菌浓度( MIC)测定, MIC测定用琼脂二倍稀释法,联合药敏测定采用棋盘法。结果银花泌炎灵对葡萄球菌和奇异变形杆菌具有较好的抗菌活性,MIC值在3.13~6.25 mg? mL-1。不论细菌是否产超广谱β内酰胺酶( ESBLs)或是否为甲氧西林耐药株或是否为环丙沙星耐药株,银花泌炎灵均表现出同样的抗菌作用。联合药敏结果显示,银花泌炎灵与阿莫西林/克拉维酸、头孢呋辛以及左氧氟沙星联合对革兰阳性菌,特别是甲氧西林耐药金黄色葡萄球菌( MRSA )有较好的协同作用。银花泌炎灵与头孢呋辛联合对粪肠球菌有协同作用,与阿莫西林/克拉维酸联合对大肠埃希菌表现出100%的相加作用。结论银花泌炎灵与β内酰胺类和喹诺酮类联合,对革兰阳性菌表现出一定的协同作用,对革兰阴性菌表现出一定的相加作用。 Objective To evaluation in vitro activity and synergy of Yin-hua Miyan Ling against main clinical isolated strains.Methods All of 285 stains from 18 tertiary hospitals in recent three years were studied. Minimal inhibition concentrations ( MIC ) were tested by Agar dilution method and combination effects were measured by Checkerboard method. Results Yinhua Miyan Ling showed more in vitro activity against Sta-phylococcus and Proteus mirabilis, MIC values from 3.13~6.25 mg? mL-1 . On the other hand, Yinhua Miyan Ling showed the same antibiotic activi-ty against extended-spectrumβlactamases ( ESBLs) positive and nega-tive strains or methecillin susceptible and resistant Staphylococcus.Syner-gy was detected with Yinhua Miyan Ling in combination with amoxillin/clavulanate, cefuroxime and levofloxacin against gram-positive strains, especially methicillin-resistant Staphylococcus aureus ( MRSA).Against E.faecalis, synergy was observed in Yinhua Miyan Ling and cefuroxime. Additive effect was found between Yinhua Miyan Ling and amoxillin/clavulanate against 100%E.coli.Conclusion Synergy was found with Yinhua Miyan Ling in combination withβlactams and quinolones against gram -positive strains and additive effect was found against gram-negative bacilli.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44409
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 北京大学 第一医院 临床药理研究所,北京,100034

Recommended Citation:
李耘,吕媛,刘健,等. 银花泌炎灵体外抗菌作用研究[J]. 中国临床药理学杂志,2015(4):279-282.
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