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IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所  > 期刊论文
学科主题: 药理学
题名:
注射用硫酸阿司米星单剂给药在健康人体的药代动力学
其他题名: Pharmacokinetics of single-dose astromicin sulfate in Chinese healthy volunteers
作者: 赵彩芸; 吕媛; 魏敏吉; 张朴; 张明; 刘燕; 梁军; 夏亚红; 张曼; 李天云; 肖永红
关键词: 硫酸阿司米星 ; 药代动力学 ; 高效液相色谱-荧光法 ; astromicin sulfate ; pharmacokinetics ; HPLC-fluorescence
刊名: 中国临床药理学杂志
发表日期: 2010
DOI: 10.3969/j.issn.1001-6821.2010.04.003
卷: 26, 期:4, 页:251-254
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 研究注射用硫酸阿司米星(胺基糖苷类抗生素)在中国健康受试者单剂量给药的药代动力学.方法 采用随机、三交叉、拉丁方设计,12名受试者随机分为3组,先后静脉滴注3个剂量(150,200,250 mg)阿司米星.收集的血、尿样本,用柱前衍生化高效液相色谱-荧光法测定其血药浓度.结果 3个剂量组(150,200,250 nag)主要药代动力学参数:C_(max)分别为(11.27±2.65),(15.83±3.14),(21.97±3.67)mg·L~(-1);t_(1/2β)分别为(2.56±0.72),(2.97±1.30),(2.66±1.39)h;AUC_(0-t)分别为(30.92±8.49),(39.58±11.57),(47.31±11.59)mg·h·L~(-1);AUC_(0-∞)分别为(31.78±8.73),(40.50±11.56),(48.20±11.95)mg·h·L~(-1);V_c分别为(11.49±2.61),(10.69±1.52),(10.20±1.93)L;CL分别为(5.33±2.03),(5.49±1.51),(5.68±1.35)L·h-1.3种剂量12 h原型药物尿中累积排泄百分率分别为(78.75±7.00)%,(78.95±12.57)%,(79.94±10.28)%.结论 不同给药剂量的阿司米星主要药代动力学参数呈线性分布特性,药物主要通过肾脏排泄,3个剂量消除过程基本一致. Objective To evaluate the pharmacokinetics of single dose of astromicin injection in healthy Chinese volunteers.Methods A randomized,three period cross-over,latin-square design study was conducted.Twelve male volunteers were administrated intravenously 150,200 and 250 mg of astromicin within 0.5 h infusion.The concentrations of astromicin in serum and urine were determinated by precolumn derivatization-fluorescence HPLC method.Results The main pharmacokinetic parameters of three dose(150,200,250 mg)were as follows:C_(max) was(11.27±2.65),(15.83±3.14)and(21.97±3.67)mg·L~(-1);t_(1/2)β was(2.56±0.72),(2.97±1.30)and(2.66±1.39)h;AUC_(0-t)was(30.92±8.49),(39.58±11.57)and(47.31±11.59)mg·h·L~(-1);AUC_(0-∞) was(31.78±8.73),(40.50±11.56)and(48.20±11.95)mg·h·L~(-1);V_c was(11.49±2.61),(10.69±1.52)and (10.20±1.93)L;CL was(5.33±2.03),(5.49±1.51)and(5.68 ±1.35)L·h~(-1),respectively.Urinary recovery rates was(78.75±7.00)%,(78.95±12.57)%and(79.94±10.28)%,respectively.Conclusion The main pharmacokinetic parameters of astromicin in difereneut doses were nearly fit linear dynamic feature,and the drug maily excreted through kidney.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44681
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 北京大学,第一医院临床药理研究所,北京,100034

Recommended Citation:
赵彩芸,吕媛,魏敏吉,等. 注射用硫酸阿司米星单剂给药在健康人体的药代动力学[J]. 中国临床药理学杂志,2010,26(4):251-254.
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