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学科主题: 药理学
题名:
2012年中国患者腹水标本分离细菌分布及敏感性分析
其他题名: Antimicrobial susceptibility pattern and epidemiology of bacteria isolated from peritoneal fluid in China in 2012
作者: 郑波1; 吕媛1; 潘义生1; 王鹏远1; 刘玉村1
关键词: 腹水 ; 细菌 ; 抗菌药 ; 耐药 ; 监测 ; peritoneal fluid ; bacteria ; antibiotics ; resistance ; surveillance
刊名: 中国临床药理学杂志
发表日期: 2015
DOI: 10.13699/j.cnki.1001-6821.2015.11.028
期: 11, 页:1022-1026
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:分析我国2012年腹水标本来源细菌分布及抗菌药敏感状况。方法2012年从557家三级医院腹水标本中分离细菌,常规方法培养分离腹水标本中的细菌,用纸片法、微量稀释法或 E -test 法测定细菌药物敏感性。结果共分离出10252株细菌,排在前5位的分别是大肠埃希菌(3215株,31.4%),肺炎克雷伯菌(860株,8.4%),屎肠球菌(703株,6.9%),铜绿假单胞菌(548株,5.3%)和表皮葡萄球菌(531株,5.2%)。金黄色葡萄球菌对苯唑西林耐药率为47.4%。未发现对万古霉素和利奈唑胺耐药的葡萄球菌。粪肠球菌和屎肠球菌对万古霉素耐药率分别为1.4%和2.5%。大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌对头孢曲松的敏感率分别为28.2%,50.8%和41.0%;对美罗培南的敏感率分别为96.7%,88.8%和96.5%。铜绿假单胞菌对碳青霉烯类、头孢他啶和头孢吡肟的敏感率超过60%,对喹诺酮类药物敏感率超过75%。鲍曼不动杆菌对碳青霉烯类药敏感率低于40%,对阿米卡星敏感率为50.8%。结论三级医院患者腹水标本分离细菌中最常见病原菌为大肠埃希菌和肺炎克雷伯菌,不同病原菌对抗菌药敏感性不同。 Objective To investigate the bacterial distribution and resis-tance to antibiotic isolated from peritoneal fluid in China, 2012.Methods The bacteria isolated from peritoneal fluid in the tertiary hospitals were routinely identified.Disc diffusion test, minimun ihibitory concentration ( MIC) test and E-test were used to detect the antimicro-bial sensitivi-ty.Results Total of 10252 pathogenic strains were collec-ted from peri-toneal fluid specimens from 557 tertiary hospitals, which included Esche-richia coli 3215 strains ( 31.4%) , Klebsiella pneumoniae 860 strains ( 8.4%) , Enterococcus faecium 730 strains ( 6.9%) , Pseu-domonas aeruginosa 548 strains ( 5.3%) and Staphylococcus epidermidis 531 strains (5.2%).The resistance rate of Staphylococcus aureus strains to oxacillin were 47.4%, no vancomycin and linezolide resistant isolate were found.The rates of susceptibility of Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacaeisolates to ceftriaxone were 28.2%, 50.8%and 41.0%, respectively;to meropenem were 96.7%, 88.8%and 96.5%, respectively.The rates of susceptibility of Pseudomonas aeruginosa to carbapenem, ceftazidime and cefepime were >60%, to quinolone was >75%.The rates of susceptibility of Acinetobacter baumannii isolates to cabarpenem were <40%, to amikacin were 50.8%.Conclusions The two most common species from peritoneal fluid in tertiary hospital were Escherichia coli and Klebsiella pneumonia.There were some difference in bacterial resistance to different antibiotics.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44705
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.北京大学 第一医院,临床药理研究所,北京 100034
2.北京大学 第一医院普通外科,北京,100034

Recommended Citation:
郑波,吕媛,潘义生,等. 2012年中国患者腹水标本分离细菌分布及敏感性分析[J]. 中国临床药理学杂志,2015(11):1022-1026.
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