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学科主题: 药理学
题名:
2012年全国三级医院尿标本分离粪肠球菌和屎肠球菌耐药状况研究
其他题名: Resistance rate of Enterococcus faecalis and Enterococcus faecium isolated from urine of the tertiary hospital of China in 2012
作者: 郑波1; 薛峰1; 张凌云1; 朱赛楠1; 李耘1
关键词: 尿 ; 粪肠球菌 ; 屎肠球菌 ; 抗菌药物 ; 耐药 ; urine ; Enterococcus faecalis ; Enterococcus faecium ; antibiotics ; resistant
刊名: 中国临床药理学杂志
发表日期: 2015
DOI: 10.13699/j.cnki.1001-6821.2015.11.032
期: 11, 页:1042-1043,1062
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:了解我国尿标本分离粪肠球菌和屎肠球菌耐药状况。方法针对尿标本中分离的189株粪肠球菌和224株屎肠球菌,用琼脂二倍稀释法进行药物敏感性分析。检测肠球菌万古霉素耐药基因型。结果粪肠球菌对氨苄西林和左氧氟沙星的敏感率分别为87.8%和61.4%,屎肠球菌对氨苄西林和左氧氟沙星的敏感率仅为6.3%和5.4%。屎肠球菌和粪肠球菌对米诺环素的敏感率分别为51.3%和19.6%。粪肠球菌和屎肠球菌对红霉素和利福平的敏感率均不足25%。粪肠球菌对万古霉素和替考拉宁的敏感率分别为99.5%和100.0%,屎肠球菌对万古霉素和替考拉宁的敏感率分别为96.9%和97.8%。1株万古霉素耐药粪肠球菌和7株万古霉素耐药屎肠球菌均携带 vanA 基因。结论尿分离粪肠球菌对氨苄西林和左氧氟沙星较为敏感,屎肠球菌对米诺环素较为敏感。肠球菌对万古霉素和替考拉宁尚保持较高敏感性。 Objective To investigate resistance of the Enterococcus faecalis and Enterococcus faecium isolated from urine in China.Methods The antimicrobial susceptibility of 189 isolates of Enterococcus faecalis and 224 isolates of Enterococcus faecium from urine was determined by argar dilu-tion.The vancomycin resistance genes were analysis of vancomycin resis-tant Enterococcus.Results The susceptibility rate of Enterococcus faecalis to ampicillin and levofloxacin were 87.8%and 61.4%, respectively, and the susceptibility of Enterococcus faecium to ampicillin and levofloxacin were 6.1% and 5.4%, respectively.The susceptibility rate of Enteroco-ccus faecium and Enterococcus faecalis to minocycline were 51.3% and 19.6%, respectively.The susceptibility rate of Enterococcus faecalis and Enterococcus faecium to erythromycin and rifampin were lower than 25%.The susceptibility rate of Enterococcus faecalis to vancomycin and teicopla-nin were 99.5%and 100.0%, and the susceptibility rate of Enterococcus faecium to vancomycin and teicoplanin were 96.9% and 97.8%.vanA gene as found in 1 isolate of vancomycin resistant Enterococcus faecalis and 5 isolates of vancomycin resistant Enterococcus faecium.Conclusion En-terococcus faecalis isolated from urine were sensitive to ampicillin and levo-floxacin, and Enterococcus faecium were more susceptible to minocycline.The Enterococcus remained sensitive to vancomycin and teicoplanin.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44708
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.北京大学 第一医院,临床药理研究所,北京 100034
2.北京大学 第一医院医学统计室,北京,100034

Recommended Citation:
郑波,薛峰,张凌云,等. 2012年全国三级医院尿标本分离粪肠球菌和屎肠球菌耐药状况研究[J]. 中国临床药理学杂志,2015(11):1042-1043,1062.
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