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IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 心血管病学
题名:
钙调神经磷酸酶依赖的信号通路在大鼠心肌肥大中的作用及调节
其他题名: Role and Regulation of Calcineurin-dependent Signal Pathway in Card iac Hypertrophy of Rats
作者: 符民桂
关键词: 心肌肥大 ; 钙调神经磷酸酶 ; 信号转导 ; 环胞素A
刊名: 生理科学进展
发表日期: 2001
卷: 32, 期:1, 页:52-54
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 本工作在大体动物模型、细胞及分 子水平上, 对钙调神经磷酸酶(CaN)依赖的信号通路在大鼠心肌肥大中的作用及其调节机制进行了研究 。结果发现:(1)CaN信号通路参与血流动力学超负荷、心肌纤维化、旁/自分泌因子等诱导 的心肌细胞肥大;(2)CaN信号通路参与血管紧张素Ⅱ(AngⅡ)及碱性成纤维细胞因子(bFGF) 诱 导的心肌细胞肥大和AngII及bFGF刺激的心脏成纤维细胞增殖;(3) CaN通路与丝裂素活化 蛋白激酶(MAPK)及蛋白激酶C(PKC)信号途径可能存在相互联系;(4)CaN的活化依赖胞内Ca 2+浓度的持续升高,CaN的活化还受蛋白激酶磷酸化的调节;AngⅡ刺激心肌细胞CaN mRNA 的表达显著增加,CaN mRNA 本身的表达受Ca2+信号及MAPK级联反应的调控。结论:C a2+-CaN信号通路介导心肌肥大的发生。 The present study investigated the role and regulation of calcine urin-dependent signal pathway in cardiac hypertrophy of rats from the three le ve ls of animal model, culturing cells and molecular biology.The results showed as follows: (1)Calcineurin signal pathway involves in myocyte hypertrophy induced by various factors such as hemodynamic overload, myocardial fibrosis, paracrine/ a utocrine factors, etc.; (2) Calcineurin-dependent signal pathway plays an im p ortant role not only in AngⅡ- and bFGF-induced cardiac myocyte hypertrophy bu t also in AngⅡ- and bFGF-stimulated cardiac fibroblast proliferation.(3)Calci n eurin pathway may associate with MAPK and PKC pathways at several levels; (4)Act i vation of calcineurin depends on sustained increase of intracellular calcium con centration and is regulated by protein phosphorylation. The expression of calcin eurin gene in AngⅡ-stimulated myocytes might be regulated by Ca2+ signal and MAPK cascade. In conclusion, Ca2+-calcineurin signal pathway involv es in the development of cardiac hypertrophy of rats.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44735
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 北京大学第一医院心血管研究所,

Recommended Citation:
符民桂. 钙调神经磷酸酶依赖的信号通路在大鼠心肌肥大中的作用及调节[J]. 生理科学进展,2001,32(1):52-54.
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