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IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 心血管病学
题名:
自发性高血压大鼠心肌和血管组织牛磺酸的转运障碍
其他题名: Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats
作者: 石彦荣; 齐永芬; 卜定方; 高霖; 王冬彦; 蒋宏峰; 庞永正; 唐朝枢
关键词: 牛磺酸 ; 转运体 ; mRNA ; 自发性高血压大鼠 ; 心肌 ; 血管 ; taurine ; transporter ; mRNA ; spontaneously hypertensive rat ; myocardial ; vessels
刊名: 生理学报
发表日期: 2002
DOI: 10.3321/j.issn:0371-0874.2002.05.001
卷: 54, 期:5, 页:359-364
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 在自发性高血压大鼠(SHR)的心肌和主动脉血管组织上观察牛磺酸(taurine)转运和牛磺酸转运体(taurine transporter, TAUT) mRNA的改变.结果显示, 与对照组WKY大鼠相比, SHR组血浆牛磺酸水平和牛磺酸释放量增加, 而心肌和血管组织牛磺酸水平和TAUT mRNA含量均降低, 牛磺酸最大转运速率(Vmax)分别低24% 和35% (P<0.05), 米氏常数(Km)值分别高16%和39% (P<0.05).这些结果提示, SHR的心肌和血管组织牛磺酸转运障碍可能与TAUT活性和亲和力降低及TAUT基因水平的下调有关. The alterations of taurine transport and the expression of taurine transporter (TAUT) mRNA in myocardium and aortic wall were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. It was demonstrated that plasma taurine concentration and taurine release from myocardium and aortic wall in SHR were higher than those in WKY rats, whereas taurine content, taurine uptake and TAUT mRNA in myocardium and aortic wall of SHR were lower than those of WKY rats. In SHR, the maximal velocity (Vmax) of taurine transportration in myocardium and aortic wall was lower by 24% (P<0.05) and 35% (P<0.05) than that in WKY, their michaelis constants (Km) values were higher by 16% (P<0.05) and 39% (P<0.05), respectively. The results suggest that there is dysfunction of taurine transport in myocardium and aortic wall in SHR, which may be partly resulted from the decrease of TAUT activity and affinity, and down-regulation of TAUT gene expression.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/44824
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 北京大学第一医院心血管病研究所,北京,100034

Recommended Citation:
石彦荣,齐永芬,卜定方,等. 自发性高血压大鼠心肌和血管组织牛磺酸的转运障碍[J]. 生理学报,2002,54(5):359-364.
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