北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科  > 期刊论文
学科主题: 泌尿外科学
题名:
慢性肾脏疾病对上尿路尿路上皮癌患者合并膀胱肿瘤风险的影响
其他题名: Chronic kidney disease as a risk factor for synchronous bladder cancer in patients with upper urinary tract urothelial carcinoma
作者: 虞巍1; 阿不都热合曼1; 何群1; 宋毅1; 金杰1
关键词: 泌尿系肿瘤 ; 癌,移行细胞 ; 膀胱肿瘤 ; 肾功能不全,慢性 ; 危险性评估 ; Urologic neoplasms ; Carcinoma,transitional cell ; Urinary bladder neoplasms ; Renal insufficiency,chronic ; Risk assessment
刊名: 中华泌尿外科杂志
发表日期: 2010
DOI: 10.3760/cma.j.issn.1000-6702.2010.10.016
卷: 31, 期:10, 页:703-706
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨慢性肾脏疾病(CKD)对上尿路尿路上皮癌(UUTUC)患者合并膀胱肿瘤风险的影响. 方法 UUTUC患者161例.男61例,女100例.平均年龄67(37~87)岁.既往有尿路移行细胞肿瘤病史者15例(9.3%).均行肾输尿管全长切除或输尿管下段切除术,病理检查证实为UUTUC.采用MDRD方程计算GFR,GFR<60 ml/min者认为存在CKD.单因素和多因素分析性别、年龄、既往尿路上皮肿瘤病史、病变数目、肿瘤分期、分级、大小、是否合并CKD等临床病理因素对UUTUC患者合并膀胱肿瘤风险的影响. 结果 161例UUTUC患者中合并膀胱肿瘤20例(12.4%),合并CKD 93例(57.8%).单因素分析显示患者合并CKD(P=0.008)和既往尿路移行细胞肿瘤病史(P=0.001)是UUTUC患者合并膀胱肿瘤的危险因素,患者性别、年龄、病变数目、肿瘤分期、分级、大小与UUTUC患者合并膀胱肿瘤无显著相关性(P>0.05).多因素分析显示CKD(HR 4.907,95%CI 1.206~19.959,P=0.026)和既往尿路上皮肿瘤病史(HR 6.444,95%CI1.699~24.445,P=0.006)是UUTUC患者合并膀胱肿瘤的独立危险因素.结论 UUTUC患者合并存在膀胱肿瘤并不少见.合并CKD和既往尿路上皮肿瘤病史是UUTUC患者合并膀胱肿瘤的独立危险因素. Objective To evaluate chronic kidney disease (CKD) as a risk factor for synchronous bladder cancer in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UUTUC). Methods Between 2005 and 2007, 161 patients (61 males and 100 females) underwent surgical management at our institution for pathologically proven UUTUC. The clinical, surgical, and pathological data were reviewed. The glomerular filtration rate(GFR) was calculated using the Modification of Diet in Renal Disease Study equation. And the presence of CKD was determined according to GFR<60 ml/min. The univariate and multivariate analyses were used to determine prognostic variables for synchronous bladder tumor. Results Of the 161 consecutive cases, the mean age was 67years (range 37 to 87 years). Twenty cases (12.4%) had simultaneous bladder tumor and UUTUC.Ninety-three patients (57.8 % ) had CKD. Fifteen cases (9.3 %) had the history of urothelial carcinoma. Univariate analyses showed that patients with CKD (P=0.008) and the history of urothelial carcinoma (P= 0.001 ) were likely to have synchronous bladder tumor;however, there was no significant impact of other factors on the synchronous intravesical disease, including age, gender, tumor multiplicity, tumor stage, tumor grade, and tumor size. Furthermore, CKD (HR 4. 907, 95% CI 1. 206-19. 959, P=0. 026) and the history of urothelial carcinoma (HR 6. 444, 95% CI 1. 699-24. 445,P=0. 006) were identified as independent predictors for the development of synchronous bladder tumor by multivariate analyses. Conclusions The incidence of synchronous bladder cancer in Chinese patients with UUTUC is not very low. Concurrent CKD and the history of urothelial carcinoma are associated with greater risk of synchronous bladder cancer in UUTUC patients.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/45572
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.北京大学泌尿外科研究所,北京大学第一医院泌尿外科,100034
2.新疆维吾尔自治区人民医院泌尿外科

Recommended Citation:
虞巍,阿不都热合曼,何群,等. 慢性肾脏疾病对上尿路尿路上皮癌患者合并膀胱肿瘤风险的影响[J]. 中华泌尿外科杂志,2010,31(10):703-706.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[虞巍]'s Articles
[阿不都热合曼]'s Articles
[何群]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[虞巍]‘s Articles
[阿不都热合曼]‘s Articles
[何群]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace