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学科主题: 泌尿外科学
题名:
β-环连蛋白及其mRNA在肾癌中的表达
其他题名: Expression of β-catenin in renal cell carcinoma
作者: 臧桐; 庄立岩; 张志文; 殿旗; 郭应禄
关键词: 肾肿瘤 ; ; β-环连蛋白 ; kidney neoplasm ; carcinoma ; β-catenin
刊名: 中华医学杂志(英文版)
发表日期: 2001
DOI: 10.3760/j.issn:0366-6999.2001.02.010
卷: 114, 期:2, 页:152-154
文章类型: Journal Article
摘要: 目的 探讨β-环连蛋白在肾癌发生发展过程中的作用及其变化机制。 方法 我们采用免疫组织化学、Western blot、RT-PCR等方法对本院收治的26例肾癌患者手术标本进行了研究。 结果 26例患者中有25例癌组织中细胞胞浆内β-环连蛋白表达明显高于正常组织内,而且肿瘤分期越高,癌细胞内β-环连蛋白的表达也越强,pT3和pT4期的肿瘤内的表达明显高于 pT1和pT2期的肿瘤,P<0.01,而其β-环连蛋白mRNA的表达水平并无明显变化。 结论 细胞内β-环连蛋白表达的增加与肾癌的发生发展有关,而且可能是肾癌形成和发展的重要机制之一。 Objective To investigate the expression of β-catenin and its mRNA in renal cell carcinoma. Methods Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR. Results We found the expression of β-catenis is higher in cancer tissues than in normal kidney tissues and the level of β-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P<0.01). That is to say, there was an overexpression of β-catenin protein in RCC and its level was related to the tumor stage, but the expression of β-catenin mRNA had no difference between tumor tissue and normal tissue. Conclusion β-catenin may be related to the occurrence and progress of RCC.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/45581
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 北京医科大学第一附属医院泌尿外科研究所 北京 100034

Recommended Citation:
臧桐,庄立岩,张志文,等. β-环连蛋白及其mRNA在肾癌中的表达[J]. 中华医学杂志(英文版),2001,114(2):152-154.
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