|摘要||目的 比较T3与T4期前列腺癌患者的生活质量,及各种治疗方式对于生活质量的影响.方法 采用前列腺癌治疗功能评价(FACT-P)问卷,以书信调查的形式,研究45例曾住院治疗的前列腺癌患者生活质量,其中T3期患者33例,T4期12例,比较T3及T4期患者的生活质量,及内分泌治疗,手术治疗加内分泌治疗,内分泌治疗加外放疗这3种治疗方式对于患者生活质量的影响.结果 从一般情况看:大部分患者并没有感到明显的不适,大部分患者及他们的家庭已经接受了患病的现实,约9l%的患者与他们的医生建立了相互信赖的关系.约60%的患者对他们的生活现状感到满意;但20%的患者担心自己的身体状况会变糟,约23%的患者受到疼痛的困扰.约96%的患者在过去1年中没有性生活,只有4%拥有勃起功能.T3期前列腺癌患者在身体状况,社会/家庭,生活状况及前列腺癌特异(PCS)生活质量等方面的评分均优于T4期患者(均P＜0.05).3种治疗方式下所反映的一般肿瘤治疗生活质量(FACT-G)及前列腺癌特异生活质量(PCS)评分之间差异无统计学意义.结论 T3期前列腺癌患者在FACT-P中所反映的身体状况,生活状况方面明显优于T4期肿瘤患者,3种治疗方式对患者的FACT-G及(PCS)生活质量的影响相当.
Objective To assess the quality of life of patients with advanced prostate cancer in China and compare the influences of different stage and different forms of therapy. Methods A corresponce questionnaire survey, using the Chinese version of functional assessment of cancer therapy-prostate(FACTP)including 47 questions concerning physical well-being, social/family well-being, relationship with doctor, life quality, and prostate cancer-specific(PCS)life quality,among 45 patients with advanced prostate cancer,aged 68.7(45-89),who had been hospitalized and underwent endocrine therapy(ET,n=27),radical prostatectomy and ET(10),ET and external radiation therapy(n=6),or ET and other drug therapy(n=2).The quality of life was investigated and the influences of canser staging and treatment methods on the quality of life were anzlyzed. Results Most patients did not have obvious bothering feelings. Most patients and their families accepted the status of illness and got support from others.91.7% of the patients trusted and relied on their doctors.39.6% of the patients were able to work and fulfill their work.60.4% of the patients were content with the qualitv of their life.95.8% of them had not been sexually active in the past year. The scores in physical well-being,social/family well-being,life quality,and PCS life quality of the patients in T3 stage were all significant higher than those of the patients in T4 stage(all P＜0.05).However, there were no difference in functional assessment of cancer therapy-general(FACTG)and PCS life quality among the 3 different treatments(all P＞0.05).Conclusion The physical wellbeing and life quality of the patients with prostate cancer at the T3 stage are significantly better than those of the patients at L4 stage. Different forms of therapy have equal influence on the FACT-G and PCS.|
张凯,龚侃,周利群,等. 晚期前列腺癌患者生活质量评估——FACT-P问卷调查[J]. 中华医学杂志,2008,88(10):665-668.