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学科主题: 泌尿外科学
题名:
肾癌相关新基因GYLZ-RCC18的表达及意义
其他题名: The significance of GYLZ-RCC18,a relatively new gene,in renal cell carcinoma
作者: 张强1; 梁丽莉1; 郭晓健1; 那彦群1; 郭应禄1; 张志文1
关键词: 肾肿瘤 ; ; 基因
刊名: 中华泌尿外科杂志
发表日期: 2001
DOI: 10.3760/j:issn:1000-6702.2001.04.001
卷: 22, 期:4, 页:197-199
收录类别: CSCD ; 中国科技核心期刊 ; 中文核心期刊
文章类型: Journal Article
摘要: 目的 探讨GYLZ-RCC18功能及在肾癌发生发展中的作用。 方法 应用SMARTRACE技术克隆GYLZ-RCC18全长,应用逆转录聚合酶链式反应(RT-PCR)特异扩增第1阅读框中504bp序列,分析在肾癌中的表达特点及与肾癌分级、分期的关系。 结果 GYLZ-RCC18基因全长约为3.5kb,在肾癌组织特异表达,正常肾组织低表达或不表达,两者表达量差异约1~9倍。GYLZ-RCC18表达在高分级分期肾癌中的表达明显高于低分级分期者。 结论 GYLZ-RCC18是肾癌组织相对特异表达的新基因,高表达与肾癌的早期发生及晚期进展密切相关。 Objective To investigate the role of GYLZ-RCC18 in the generationand development of renal cell carcinoma (RCC). Methods By using SMART RACE and RT-PCR the full length of GYLZ-RCC18 was cloned and its expression was detected in RCC of different grade and stage by amplification of a special fragment sequence in the first reading frame about 504 bp. Results The full length of GYLZ-RCC18 about 3.5 kb expressed in RCC in higher level than in normal kidney tissue.GYLZ-RCC18 overexpressed in high grade and high stage RCC being 1-9 folds higher than that in low grade and low stage ones. Conclusions GYLZ-RCC18 is a new gene especially related to RCC and is closely related to the generation and development of RCC.Study of the gene will be helpful in the understanding of the molecular mechanism of the generation and development of RCC and may direct the diagnosis and treatment of RCC.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/45629
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.100034 北京大学第一医院,北京大学泌尿外科研究所
2.北京大学医学部生理系

Recommended Citation:
张强,梁丽莉,郭晓健,等. 肾癌相关新基因GYLZ-RCC18的表达及意义[J]. 中华泌尿外科杂志,2001,22(4):197-199.
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