IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
其他题名Causes of on-demand sildenafil failure and rechallenging treatment
张志超; 彭靖; 高冰; 袁亦铭; 宋卫东; 辛钟成; 金杰; 郭应禄
关键词勃起功能障碍 西地那非 医疗无效 Erectile Dysfunction Sildenafil Medical Fatility
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 分析按需口服西地那非治疗勃起功能障碍(ED)无效原因并制定治疗策略.方法 2009年1-12月因ED就诊、正确服用西地那非100 mg、至少4次无效的患者126例.采用国际勃起功能指数调查表5个简化问题(IIEF-5)评分、实时勃起功能检测、血清睾酮检测、阴茎多普勒超声检查评估ED治疗无效的原因,患者进行充分的性教育,接受每晚西地那非50 mg治疗.采用IIEF-5评分和性生活日记问题2和3评价再次治疗后的效果.结果 126例ED患者中心理性ED41例,合并睾酮水平低下39例,糖尿病性ED 28例,血管性ED 18例.经过每日小剂量西地那非治疗4周,治疗前后IIEF-5评分分别为(12.3±2.9)分和(18.8±4.4)分,差异有统计学意义(P<0.05).成功完成性生活者78例,有效率61.9%.结论按需口服西地那非治疗无效的患者经过充分的性教育、长期小剂量治疗后,大部分患者对西地那非治疗仍然有效. Objective To assess the causes of sildenafil failure and the feasibility of successfully rechallenging non-responding patients. Methods A total of 126 consecutive erectile dysfunction (ED) patients from Jan 2009 to Dec 2009 who claimed poor response to sildenafil (sildenafil 100 mg on demand, at lease 4 epiodes) were enrolled into the study. All patients received sexual reeducation and were treated with sildenafil, taken on a daily dose of 50 mg for 4 weeks. The International Index of Erectile Function-5 (IIEF-5), Rigiscan, serum testosterone or penile Doppler were used to evaluate ED and the cause of on-demand sildenafil failure. End point efficacy of rechallenging was evaluated using the IIEF-5 and the sexual encounter profile (SEP) 'Were you able to insert your penis into your partner's vagina?' and 'Did your erection last long enough to achieve successful intercourse?'. Results The recruited patients comprised of 41 cases with psychological ED, 39 cases with hypogonadism ED, 28 cases with diabetes mellitus ED and 18 cases with vascular ED. Compared with pretreatment and on-demand sildenafil baseline, daily administration of sildenafil significantly enhanced all efficacy outcome variables. The IIEF-5 was significantly improved after daily sildenafil (12.3 ± 2.9 vs18. 8±4.4, P<0.01), 78 patients responded to daily sildenafil. The overall salvage rate was 61.9%(78/126). Conclusions Sexual reeducation and daily administration of sildenafil may be able to salvage many patients with ED who were sildenafil non-responders.
Citation statistics
Recommended Citation
GB/T 7714
张志超,彭靖,高冰,等. 西地那非治疗勃起功能障碍无效的原因分析及治疗对策[J]. 中华泌尿外科杂志,2011,32(3):172-175.
APA 张志超.,彭靖.,高冰.,袁亦铭.,宋卫东.,...&郭应禄.(2011).西地那非治疗勃起功能障碍无效的原因分析及治疗对策.中华泌尿外科杂志,32(3),172-175.
MLA 张志超,et al."西地那非治疗勃起功能障碍无效的原因分析及治疗对策".中华泌尿外科杂志 32.3(2011):172-175.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
谷歌学术Similar articles in
[张志超]'s Articles
[彭靖]'s Articles
[高冰]'s Articles
百度学术Similar articles in
[张志超]'s Articles
[彭靖]'s Articles
[高冰]'s Articles
必应学术Similar articles in
[张志超]'s Articles
[彭靖]'s Articles
[高冰]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.