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学科主题: 肾脏病学
题名:
丙型肝炎病毒抗原在丙型肝炎并发肾小球肾炎肾组织中的检测及其临床意义
其他题名: Detection of hepatitis C virus-antigen in kidney tissue from infected patients with glomerulonephritis and its clinical implications
作者: 曹娅丽; 章友康; 王素霞; 鄂洁; 邹万忠
关键词: 肝炎,丙型 ; 肾小球肾炎 ; 肝炎抗原,丙型 ; NS3 ; Hepatitis C ; Glomerulonephritis ; Hepatitis C antigen ; NS3
刊名: 中华肾脏病杂志
发表日期: 2008
DOI: 10.3321/j.issn:1001-7097.2008.12.001
卷: 24, 期:12, 页:859-864
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨肾组织中检出丙型肝炎病毒(HCV)抗原在HCV感染并发肾小球肾炎(GN)中的意义.方法 用HCV.NS3单克隆抗体对21例(其中7例患者肾活检时血清HCV-RNA定性为阳性)HCV感染并发GN患者的肾组织石蜡切片进行了HCV-NS3抗原的免疫组化检测,并分析其临床、病理特征.结果 6例(6/21)检出了HCV-NS3抗原,可以诊断为HCV相关性GN.7例肾活检时血清HCV-RNA阳性伴GN患者肾组织中,4例(4/7)检到HCV-NS3抗原.HCV-NS3抗原主要在肾小球毛细血管袢和(或)系膜区沉积.HCV抗原检出组的病理类型主要表现为膜增殖性GN(MPGN,3/6).免疫组化HCV阳性组的发病年龄和尿蛋白量(24 h)显著大于阴性组(P=0.01);血清补体C3显著低于阴性组(P=O.01).结论 HCV抗原在肾组织中的检出对于HCV相关性GN的诊断以及肾损害程度的判断有重要意义. Objective To explore the indications of detecting hepatitis C virus(HCV)antigen in kidney tissue from infected patients with glomerulonephritis(GN). Methods Twentyone patients with various GN were found to be HCV-antibedy positive (7 serum HCV-RNA positive simultaneously), at the time of renal biopsy, from January 2005 to April 2008 in our hospital. Murine monoclonal antibody against NS3 protein was employed to detect HCV-antigen by immunohistochemistry. In addition, comprehensive investigations of these 21 patients were undertaken including an evaluation of their clinical, biochemical, virological and immunological parameters. Results HCV-NS3 antigen was detected in six (6/21) HCV-antibody positive patients and four out of the seven were serum HCV-RNA positive (4/7 in HCV-RNA positive,57.1%). HCV immunoreactive deposits mainly displayed along glomernlar capillary walls and/or mesangial region. MPGN was the most common type of GN accounting for 50% of HCV-NS3 immunoreactive staining patients. It seemed worth emphasizing that the mean age, urinary protein loss were significantly higher in HCV-NS3 positive patients than in those negative (P=0.01), while serum C3 level was significantly lower in the former group (P=0.01). Conclusion Detection of HCV-antigen in kidney tissue can not only provide a direct evidence for the diagnosis of HCV-associated GN, but also give an indication of pathogenic role of HCV in the renal damage.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/45775
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 北京大学肾脏病研究所,北京大学第一医院肾内科,100034

Recommended Citation:
曹娅丽,章友康,王素霞,等. 丙型肝炎病毒抗原在丙型肝炎并发肾小球肾炎肾组织中的检测及其临床意义[J]. 中华肾脏病杂志,2008,24(12):859-864.
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