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学科主题: 肾脏病学
题名:
最新 KDIGO 急性肾损伤指南在新月体肾炎中的应用
其他题名: Validation of 2012 KDIGO AKI guideline in patients with crescent glomerulonephritis
作者: 初荣; 刘晓静; 郑欣; 鄂洁; 王素霞; 杨莉; 刘刚
关键词: 肾病 ; 急性肾损伤 ; KDIGO ; 新月体肾炎 ; Nephrosis ; Acute kidney injury ; KDIGO ; Crescent glomerulonephritis
刊名: 中华临床医师杂志(电子版)
发表日期: 2013
DOI: 10.3877/cma.j.issn.1674-0785.2013.06.007
期: 6, 页:2314-2317
文章类型: Journal Article
摘要: 目的分析2012年国际改善全球肾脏病预后组织(KDIGO)发表的急性肾损伤(AKI)和急性肾脏病( AKD)定义在不同类型的新月体肾炎中的应用。方法2009年1月至2012年12月在北京大学第一医院肾内科住院接受肾活检其光镜病理检查超过50%肾小球内有新月体形成的患者。根据2012年KDIGO指南AKI/AKD的定义,以血肌酐(Scr)和24 h尿量为指标将入选的患者分为AKI组,非AKI的AKD组,非AKD组和无法分类组。结果 AKD能够识别84.2%的新月体肾炎患者,而AKI仅能识别61.4%的患者。对于不同类型的新月体肾炎,AKI识别抗GBM抗体型最高,达91%。新月体性肾小球肾炎较肾小球肾炎伴多数新月体形成更易被AKI识别( P=0.002)。不同成分为主的新月体肾炎, AKI/AKD的识别无统计学差异。结论2012年KDIGO AKD的定义比AKI更能够早期识别急性肾功能不全的患者。 Objective To validate whether 2012 KDIGO definitions of AKI and AKD were applicable for patients with crescent glomerulonephritis .Methods Patients who were pathologically defined as ≥50% of the glomeruli having crescents between 1 January 2009 and 31 December 2012 were enrolled in the study .2012 KDIGO AKD and AKI definition were applied to identify patients with AKI , AKD without AKI , non-AKD and unclassified group according to the changes of serum creatinine ( Scr ) and urine volume throughout the disease course . Results The AKD definition could recognize 84.2% of the patients with crescent glomerulonephritis , while AKI could only identify 61.4% of such patients .For different types of crescent glomerulonephritis , anti-GBM type was recognized by AKI at best ( 91%) .AKI could identify crescentic glomerulonephritis better than glomerulonephritis with majority crescents formation ( P=0.002 ) .There was no statistically significance between different composition of crescent,irrespectively of AKI/AKD criterion.Conclusions The KDIGO AKD definition can detect patients with renal dysfunction of crescent glomerulonephritis earlier than AKI .
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/45800
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 100034,北京大学第一医院肾内科 北京大学肾脏疾病研究所 卫生部肾脏疾病重点实验室 慢性肾脏病防治教育部重点实验室

Recommended Citation:
初荣,刘晓静,郑欣,等. 最新 KDIGO 急性肾损伤指南在新月体肾炎中的应用[J]. 中华临床医师杂志(电子版),2013(6):2314-2317.
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