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学科主题: 临床医学
题名:
小Y核型对男性不育影响的临床分析
其他题名: The Clinical analysis of the influence of bit Y chromosome abnormality on male fertile function
作者: 陈亮; 付杰; 陈菲; 潘虹; 王玲; 鞠慧岩; 薛晴; 贺占举; 左文莉; 徐阳
关键词: 染色体核型 ; 小Y染色体 ; 男性不育症 ; Chromosome configuration ; Bit Y chromosome ; Male infertility
刊名: 中国性科学
发表日期: 2014
DOI: 10.3969/j.issn.1672-1993.2014.08.027
期: 8, 页:74-76
收录类别: 中国科技核心期刊
文章类型: Journal Article
摘要: 目的:探讨单纯小Y染色体核型对男性生育障碍的影响及其临床意义。方法:研究对象分为A组(男性不育)及B组(配偶既往不良妊娠史或羊水穿刺示胎儿染色体异常等),比较不同组别间小Y核型的检出率并分析其临床效应。结果:共检出30例小Y核型。其中A组12例,B组18例。两组间小Y核型的检出率没有显著差异(P=0.971)。小Y核型的临床效应为:无精症、少精症、配偶胚胎停育、自然流产等不良妊娠结局。结论:小Y核型可能具备某些潜在的临床效应,可能会对男性生精过程及配偶的不良妊娠结局产生影响,需要在分子生物学及功能基因组学层面继续深入验证。 To investigate the effects of bit Y chromosome configuration on male fertility and to evaluate the relevant clinical significance.Methods:The relevant cases were divided into two groups,where A group included male infertile cases while B group included cases whose wife had adverse pregnancy history or the ab-normal amniotic fluid punctures.Cytogenetics of patients was examined by culturing peripheral-blood lymphocyte and G-banding technology,and karyotyping analysis technique was used to study the bit Y chromosome in two dif-ferent groups.Results:Among the 2139 cases,30 cases were found with abnormal karyotype of bit Y chromo-some.,including 12 ones in group A and 18 ones in group B,with no significant difference (P=0.971).The main clinical effects of bit Y were azoospermia,oligozoospermia,miscarriage,embryonic diapause and fetal anomalies,et al.Conclusion:The bit Y chromosomal abnormality may have some potential clinical effects which may affect the spermatogenesis and adverse pregnancy.Therefore,a detailed mechanism study needs to be further investigated.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/46404
Appears in Collections:北京大学第一临床医学院_妇产科_期刊论文

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作者单位: 北京大学第一医院生殖与遗传医疗中心,北京,100034

Recommended Citation:
陈亮,付杰,陈菲,等. 小Y核型对男性不育影响的临床分析[J]. 中国性科学,2014(8):74-76.
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