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长春瑞滨联合顺铂对蒽环类联合紫杉类辅助化疗失败的乳腺癌患者的疗效分析
其他题名Effects and toxicity of neoadjuvant chemotherapy with vinorelbine and cisplatin in treatment of operable breast cancer previously non-responsive to anthracyclines and taxans-containing regimen: analysis of 19 cases
徐玲; 叶京明; 赵建新; 段学宁; 刘荫华
关键词乳腺肿瘤 顺铂 药物疗法 蒽环类 联合 长春瑞滨 Breast Neoplasms Cisplatin Drug Therapy Anthraxcyclines Combination Vinorelbine
刊名中华医学杂志
2009
DOI10.3760/cma.j.issn.0376-2491.2009.10.011
89期:10页:683-685
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨长春瑞滨联合顺铂(NP方案)对蒽环类联合紫杉类新辅助化疗失败的乳腺癌的近期疗效和毒副作用.方法 2007年9月至2008年5月,针对19例蒽环类联合紫杉类方案新辅助化疗未达临床PR、CR的乳腺癌患者,更换NP方案新辅助化疗2个周期,通过动态增强MRI检查对临床疗效进行评估后实施手术治疗,并观察病灶的病理缓解情况及毒副反应.结果 临床疗效评价:CR1例,PR9例,SD9例,PD0例,总有效率(CR+PR)52.6%(10/19).病理疗效评价G12例,G27例,G36例,G44例,G50例,反应率(G2+G3+G4+G5)89.5%(17/19),常见毒副反应为骨髓抑制和胃肠道反应.结论 NP方案作为蒽环类联合紫杉类新辅助化疗失败的二线新辅助化疗方案,有效率高.患者耐受性好,不良反应可逆,无治疗相关死亡.可以成为总环类联合紫杉类新辅助化疗无效患者的二线优选方案. Objective To evaluate the short-term effects and toxicity of vinorelbine combined with cisplatin (NP) as a neoadjuvant chemotherapy regimen in treatment of operable breast cancer non-responsive to the combination of anthraxcyclines and taxans. Methods Nineteen breast cancer patients, all female, who failed to achieve complete remission (CR) or partial remission (PR) to the combination of anthracyclines and taxans as neoadjuvant regimen were treated with 2 cycles of NP regimen (vinorelbine 25 mg/m2, on days 1 and 8 and cisplatin 70 mg/m2, on days 1 and 3, both by intravenous infusion, as a cycle). The clinical objective response was evaluated with dynamic contrast-enhanced MRI of the breast before operation and the pathological response was evaluated by pathological examination. The toxicity of the NP regimen was evaluated according to National Cancer Institute- Common Toxicity Criteria v. 3.0. Results The CR + PR rate of the NP regime was 52.6% (10/19), and pathological response (G2+G3+G4+G5) was found in 17 cases (89.5%, 17/19). The most common toxicities were neutropenia and nausea/vomiting. These toxicities were reversible and did not cause death. Conclusion A well-tolerated and effective regimen for breast cancer patient who fail to respond to the combination of anthracyclines and taxans neoadjuvant chemotherapy, the NP regimen can be considered as an effective choice of second-line regimen. It can be considered as an effective choice of second-line regimen.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/46647
专题北京大学第一临床医学院
北京大学第一临床医学院_普通外科
北京大学第一临床医学院_肿瘤化疗科
作者单位北京大学第一医院乳腺中心,100034
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GB/T 7714
徐玲,叶京明,赵建新,等. 长春瑞滨联合顺铂对蒽环类联合紫杉类辅助化疗失败的乳腺癌患者的疗效分析[J]. 中华医学杂志,2009,89(10):683-685.
APA 徐玲,叶京明,赵建新,段学宁,&刘荫华.(2009).长春瑞滨联合顺铂对蒽环类联合紫杉类辅助化疗失败的乳腺癌患者的疗效分析.中华医学杂志,89(10),683-685.
MLA 徐玲,et al."长春瑞滨联合顺铂对蒽环类联合紫杉类辅助化疗失败的乳腺癌患者的疗效分析".中华医学杂志 89.10(2009):683-685.
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